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Proteinase-3, a serine protease which mediates doxorubicin-induced apoptosis in the HL-60 leukemia cell line, is downregulated in its doxorubicin-resistant variant.
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.
Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas.
Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.
Ceramide induced mitophagy and tumor suppression.
Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML.
Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells.
Mitochondrial protein import is regulated by p17/PERMIT to mediate lipid metabolism and cellular stress.
Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T?cell response.