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Sambamurti, Kumar
One or more keywords matched the following items that are connected to Sambamurti, Kumar
Item TypeName
Academic Article ERAB contains a putative noncleavable signal peptide.
Academic Article Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells.
Academic Article Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert.
Academic Article Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model.
Academic Article A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor.
Academic Article Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease.
Academic Article The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells.
Academic Article Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein.
Academic Article Lipid rafts play an important role in A beta biogenesis by regulating the beta-secretase pathway.
Academic Article Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme.
Academic Article 17beta-estradiol reduces plasma Abeta40 for HRT-na?ve postmenopausal women with Alzheimer disease: a preliminary study.
Academic Article Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent.
Academic Article Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels.
Academic Article Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide.
Academic Article The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice.
Academic Article Genotoxicity in Alzheimer's disease: role of amyloid.
Academic Article Cell-free assays for gamma-secretase activity.
Academic Article Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.
Academic Article Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma.
Academic Article Role of DNA dynamics in Alzheimer's disease.
Academic Article High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice.
Academic Article Value in development of a TAPIR-like mouse monoclonal antibody to Abeta.
Academic Article Beta-secretase: structure, function, and evolution.
Academic Article Neuronutrition and Alzheimer's disease.
Academic Article Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo.
Academic Article Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.
Academic Article APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.
Academic Article Major carboxyl terminal fragments generated by ?-secretase processing of the Alzheimer amyloid precursor are 50 and 51 amino acids long.
Academic Article Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).
Academic Article Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization.
Academic Article Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents.
Academic Article Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.
Academic Article Neurine, an acetylcholine autolysis product, elevates secreted amyloid-beta protein precursor and amyloid-beta peptide levels, and lowers neuronal cell viability in culture: a role in Alzheimer's disease?
Academic Article Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors.
Academic Article An increase in Abeta42 in the prefrontal cortex is associated with a reversal-learning impairment in Alzheimer's disease model Tg2576 APPsw mice.
Academic Article GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism.
Academic Article GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.
Academic Article The genesis of the senile plaque. Further evidence in support of its neuronal origin.
Concept Peptides
Concept Amyloid beta-Peptides
Academic Article Evidence of a novel mechanism for partial ?-secretase inhibition induced paradoxical increase in secreted amyloid ? protein.
Academic Article Evidence for lymphatic A? clearance in Alzheimer's transgenic mice.
Academic Article Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease.
Academic Article Resolution of inflammation is altered in Alzheimer's disease.
Academic Article Beta-Amyloid Precursor Protein (?APP) Processing in Alzheimer's Disease (AD) and Age-Related Macular Degeneration (AMD).
Academic Article Melatonin Treatment Enhances A? Lymphatic Clearance in a Transgenic Mouse Model of Amyloidosis.
Academic Article Rivastigmine modifies the a-secretase pathway and potentially early Alzheimer's disease.
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