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Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts.
Thrombin-mediated cellular events in pulmonary fibrosis associated with systemic sclerosis (scleroderma).
Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts.
Thrombin increases lung fibroblast survival while promoting alveolar epithelial cell apoptosis via the endoplasmic reticulum stress marker, CCAAT enhancer-binding homologous protein.
Receptor PAR 1