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Singh, Inderjit
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Academic Article Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages.
Academic Article Studies on hepatic injury and antioxidant enzyme activities in rat subcellular organelles following in vivo ischemia and reperfusion.
Academic Article Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes.
Academic Article Therapy for X-adrenoleukodystrophy: normalization of very long chain fatty acids and inhibition of induction of cytokines by cAMP.
Academic Article Cytokine-induced accumulation of very long-chain fatty acids in rat C6 glial cells: implication for X-adrenoleukodystrophy.
Academic Article N-acetyl cysteine inhibits induction of no production by endotoxin or cytokine stimulated rat peritoneal macrophages, C6 glial cells and astrocytes.
Academic Article Cytokine-mediated induction of ceramide production is redox-sensitive. Implications to proinflammatory cytokine-mediated apoptosis in demyelinating diseases.
Academic Article Inhibition of phosphatidylinositol 3-kinase induces nitric-oxide synthase in lipopolysaccharide- or cytokine-stimulated C6 glial cells.
Academic Article Abnormality in catalase import into peroxisomes leads to severe neurological disorder.
Academic Article Inhibitors of protein phosphatase 1 and 2A differentially regulate the expression of inducible nitric-oxide synthase in rat astrocytes and macrophages.
Academic Article Demonstration of Cu-Zn superoxide dismutase in rat liver peroxisomes. Biochemical and immunochemical evidence.
Academic Article Transport of fatty acids into human and rat peroxisomes. Differential transport of palmitic and lignoceric acids and its implication to X-adrenoleukodystrophy.
Academic Article Intraperoxisomal localization of very-long-chain fatty acyl-CoA synthetase: implication in X-adrenoleukodystrophy.
Academic Article Endotoxin-induced alterations of lipid and fatty acid compositions in rat liver peroxisomes.
Academic Article Identification of the pathway of alpha-oxidation of cerebronic acid in peroxisomes.
Academic Article Localization of nervonic acid beta-oxidation in human and rodent peroxisomes: impaired oxidation in Zellweger syndrome and X-linked adrenoleukodystrophy.
Academic Article Effect of salicylic acid and calcium on mitochondrial functions.
Academic Article Ischemia-reperfusion injury: biochemical alterations in peroxisomes of rat kidney.
Academic Article Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide.
Academic Article Amelioration of experimental allergic encephalomyelitis in Lewis rats by lovastatin.
Academic Article Peroxisomal enzyme activities in brain and liver of pups of lactating mothers treated with ciprofibrate.
Academic Article Attenuation of renal ischemia/reperfusion injury by a triple drug combination therapy.
Academic Article Rho A negatively regulates cytokine-mediated inducible nitric oxide synthase expression in brain-derived transformed cell lines: negative regulation of IKKalpha.
Academic Article Potential targets of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for multiple sclerosis therapy.
Academic Article 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside inhibits proinflammatory response in glial cells: a possible role of AMP-activated protein kinase.
Academic Article Regulation of gene expression associated with acute experimental autoimmune encephalomyelitis by Lovastatin.
Academic Article A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon-gamma-mediated inducible nitric oxide synthase gene expression: implications for neuroinflammatory diseases.
Academic Article Attenuation of ischemia-reperfusion injury in a canine model of autologous renal transplantation.
Academic Article N-acetylcysteine prevents endotoxin-induced degeneration of oligodendrocyte progenitors and hypomyelination in developing rat brain.
Academic Article Dual role of cAMP in iNOS expression in glial cells and macrophages is mediated by differential regulation of p38-MAPK/ATF-2 activation and iNOS stability.
Academic Article Endotoxin induces structure-function alterations of rat liver peroxisomes: Kupffer cells released factors as possible modulators.
Academic Article Isolation and biochemical characterization of peroxisomes from cultured rat glial cells.
Academic Article Kidney ischemia-reperfusion: modulation of antioxidant defenses.
Academic Article Adenosine kinase inhibitor attenuates the expression of inducible nitric oxide synthase in glial cells.
Academic Article A novel role of lactosylceramide in the regulation of tumor necrosis factor alpha-mediated proliferation of rat primary astrocytes. Implications for astrogliosis following neurotrauma.
Academic Article Involvement of phospholipase A2 and lipoxygenase in lipopolysaccharide-induced inducible nitric oxide synthase expression in glial cells.
Academic Article Peroxisomal participation in psychosine-mediated toxicity: implications for Krabbe's disease.
Academic Article 5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis.
Academic Article Postnatal development and isolation of peroxisomes from brain.
Academic Article HMG-CoA reductase inhibitor augments survival and differentiation of oligodendrocyte progenitors in animal model of multiple sclerosis.
Academic Article The use of N-acetylcysteine for the prevention of hypertension in the reduced uterine perfusion pressure model for preeclampsia in Sprague-Dawley rats.
Academic Article 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitro and in vivo via AMP-activated protein kinase.
Academic Article Rho/ROCK pathway as a target of tumor therapy.
Academic Article Cerebrovascular protection by various nitric oxide donors in rats after experimental stroke.
Academic Article Dysfunction of peroxisomes in twitcher mice brain: a possible mechanism of psychosine-induced disease.
Academic Article Combination of systemic hypothermia and N-acetylcysteine attenuates hypoxic-ischemic brain injury in neonatal rats.
Academic Article Krabbe disease: psychosine-mediated activation of phospholipase A2 in oligodendrocyte cell death.
Academic Article Pharmacological strategies for the regulation of inducible nitric oxide synthase: neurodegenerative versus neuroprotective mechanisms.
Academic Article Molecular organization of peroxisomal enzymes: protein-protein interactions in the membrane and in the matrix.
Academic Article T-bet is essential for the progression of experimental autoimmune encephalomyelitis.
Academic Article Immunomodulatory effect of combination therapy with lovastatin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside alleviates neurodegeneration in experimental autoimmune encephalomyelitis.
Academic Article Complement plays an important role in spinal cord injury and represents a therapeutic target for improving recovery following trauma.
Academic Article Post-trauma Lipitor treatment prevents endothelial dysfunction, facilitates neuroprotection, and promotes locomotor recovery following spinal cord injury.
Academic Article Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia.
Academic Article S-nitrosoglutathione prevents interphotoreceptor retinoid-binding protein (IRBP(161-180))-induced experimental autoimmune uveitis.
Academic Article Lactosylceramide: a lipid second messenger in neuroinflammatory disease.
Academic Article Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis.
Academic Article Effect of clofibrate on peroxisomal lignoceroyl-CoA ligase activity.
Academic Article Loss of AMPK exacerbates experimental autoimmune encephalomyelitis disease severity.
Academic Article Metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis.
Academic Article Topographical localization of peroxisomal acyl-CoA ligases: differential localization of palmitoyl-CoA and lignoceroyl-CoA ligases.
Academic Article Peroxisomal dysfunction in inflammatory childhood white matter disorders: an unexpected contributor to neuropathology.
Academic Article Reduction of lipoxidative load by secretory phospholipase A2 inhibition protects against neurovascular injury following experimental stroke in rat.
Academic Article Mitochondrial membrane fluidity changes in renal ischemia.
Academic Article Very long-chain fatty acid accumulation causes lipotoxic response via 5-lipoxygenase in cerebral adrenoleukodystrophy.
Academic Article Factors that affect postnatal bone growth retardation in the twitcher murine model of Krabbe disease.
Academic Article N-acetylcysteine attenuates the maternal and fetal proinflammatory response to intrauterine LPS injection in an animal model for preterm birth and brain injury.
Academic Article Peroxisomal fatty acid oxidation and cellular redox.
Academic Article Preclinical use of longitudinal MRI for screening the efficacy of S-nitrosoglutathione in treating spinal cord injury.
Academic Article Progressive endoplasmic reticulum stress contributes to hepatocarcinogenesis in fatty acyl-CoA oxidase 1-deficient mice.
Academic Article HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes.
Academic Article X-ray diffraction analysis of myelin lipid/proteolipid protein multilayers.
Academic Article Spinal cord injury induced arrest in estrous cycle of rats is ameliorated by S-nitrosoglutathione: novel therapeutic agent to treat amenorrhea.
Academic Article N-acetylcysteine prevents preterm birth by attenuating the LPS-induced expression of contractile associated proteins in an animal model.
Academic Article Stimulation of functional recovery via the mechanisms of neurorepair by S-nitrosoglutathione and motor exercise in a rat model of transient cerebral ischemia and reperfusion.
Academic Article Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis.
Academic Article The inhibitory effect of S-nitrosoglutathione on blood-brain barrier disruption and peroxynitrite formation in a rat model of experimental stroke.
Academic Article Simvastatin ameliorates cauda equina compression injury in a rat model of lumbar spinal stenosis.
Academic Article Caffeic acid phenethyl ester induces adrenoleukodystrophy (Abcd2) gene in human X-ALD fibroblasts and inhibits the proinflammatory response in Abcd1/2 silenced mouse primary astrocytes.
Academic Article Combination therapy of N-acetylcysteine, sodium nitroprusside and phosphoramidon attenuates ischemia-reperfusion injury in rat kidney.
Academic Article N-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemia.
Academic Article Modulation of Rho-Rock signaling pathway protects oligodendrocytes against cytokine toxicity via PPAR-a-dependent mechanism.
Academic Article Acyl-CoA ligases from rat brain microsomes: an immunochemical study.
Academic Article Fatty acid metabolism in renal ischemia.
Academic Article Effect of salicylic acid on mitochondrial-peroxisomal fatty acid catabolism.
Academic Article Synthesis and acylation of myelin proteolipid protein in quaking mouse brain.
Academic Article The involvement of glucose metabolism in the regulation of inducible nitric oxide synthase gene expression in glial cells: possible role of glucose-6-phosphate dehydrogenase and CCAAT/enhancing binding protein.
Academic Article Impairment of peroxisomal beta-oxidation system by endotoxin treatment.
Academic Article CuZn superoxide dismutase: intraorganellar distribution in peroxisomes.
Academic Article Morphological analysis of mitochondrial integrity in prolonged cold renal ischemia utilizing Euro-Collins versus University of Wisconsin preservation solution in a whole organ model.
Academic Article Expression of antioxidant enzymes in rat kidney during ischemia-reperfusion injury.
Academic Article Alterations of peroxisomal function in ischemia-reperfusion injury of rat kidney.
Academic Article Phytanic acid alpha-oxidation. Differential subcellular localization in rat and human tissues and its inhibition by nycodenz.
Academic Article Tissue differences in antioxidant enzyme gene expression in response to endotoxin.
Academic Article Biochemistry of peroxisomes in health and disease.
Academic Article Increasing cAMP attenuates induction of inducible nitric-oxide synthase in rat primary astrocytes.
Academic Article The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase.
Academic Article Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke.
Academic Article Inflammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E.
Academic Article Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment.
Academic Article The 15-deoxy-delta12,14-prostaglandin J2 inhibits the inflammatory response in primary rat astrocytes via down-regulating multiple steps in phosphatidylinositol 3-kinase-Akt-NF-kappaB-p300 pathway independent of peroxisome proliferator-activated receptor gamma.
Academic Article Attenuation of acute inflammatory response by atorvastatin after spinal cord injury in rats.
Academic Article S-Nitrosoglutathione reduces inflammation and protects brain against focal cerebral ischemia in a rat model of experimental stroke.
Academic Article Inhibition of phosphoinositide 3 kinase-Akt (protein kinase B)-nuclear factor-kappa B pathway by lovastatin limits endothelial-monocyte cell interaction.
Academic Article Effect of ciprofibrate on the activation and oxidation of very long chain fatty acids.
Academic Article IL-4-induced peroxisome proliferator-activated receptor gamma activation inhibits NF-kappaB trans activation in central nervous system (CNS) glial cells and protects oligodendrocyte progenitors under neuroinflammatory disease conditions: implication for CNS-demyelinating diseases.
Academic Article Sphingolipid signaling and redox regulation.
Academic Article 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction.
Academic Article Lipid peroxidation and oxidation of lignoceric acid in kidneys from thioridazine treated rats.
Academic Article GSNO attenuates EAE disease by S-nitrosylation-mediated modulation of endothelial-monocyte interactions.
Academic Article Modulation of peroxisome proliferator-activated receptor-alpha activity by N-acetyl cysteine attenuates inhibition of oligodendrocyte development in lipopolysaccharide stimulated mixed glial cultures.
Academic Article Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis.
Academic Article The role of AMPK in psychosine mediated effects on oligodendrocytes and astrocytes: implication for Krabbe disease.
Academic Article Lovastatin inhibits amyloid precursor protein (APP) beta-cleavage through reduction of APP distribution in Lubrol WX extractable low density lipid rafts.
Academic Article Lipopolysaccharide-induced peroxisomal dysfunction exacerbates cerebral white matter injury: attenuation by N-acetyl cysteine.
Academic Article Plasmalogen deficiency in cerebral adrenoleukodystrophy and its modulation by lovastatin.
Academic Article Attenuation of lipopolysaccharide-induced inflammatory response and phospholipids metabolism at the feto-maternal interface by N-acetyl cysteine.
Academic Article Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death.
Academic Article Psychosine-induced alterations in peroxisomes of twitcher mouse liver.
Academic Article Combination therapy of lovastatin and rolipram provides neuroprotection and promotes neurorepair in inflammatory demyelination model of multiple sclerosis.
Academic Article Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy.
Academic Article Neuroprotective interventions: is it too late?
Academic Article Administration of S-nitrosoglutathione after traumatic brain injury protects the neurovascular unit and reduces secondary injury in a rat model of controlled cortical impact.
Academic Article S-nitrosoglutathione a physiologic nitric oxide carrier attenuates experimental autoimmune encephalomyelitis.
Academic Article Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected].
Academic Article Activation of PPAR-? and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells.
Academic Article Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis.
Academic Article Increased Plp1 gene expression leads to massive microglial cell activation and inflammation throughout the brain.
Academic Article Synergistic activity of interleukin-17 and tumor necrosis factor-a enhances oxidative stress-mediated oligodendrocyte apoptosis.
Academic Article S-nitrosoglutathione reduces oxidative injury and promotes mechanisms of neurorepair following traumatic brain injury in rats.
Academic Article Adrenoleukodystrophy: impaired oxidation of fatty acids due to peroxisomal lignoceroyl-CoA ligase deficiency.
Academic Article Protective role of S-nitrosoglutathione (GSNO) against cognitive impairment in rat model of chronic cerebral hypoperfusion.
Academic Article S-nitrosoglutathione induces ciliary neurotrophic factor expression in astrocytes, which has implications to protect the central nervous system under pathological conditions.
Academic Article Role of endogenous psychosine accumulation in oligodendrocyte differentiation and survival: implication for Krabbe disease.
Academic Article Effect of ischemia and 24 hour reperfusion on ATP synthesis in the rat kidney.
Academic Article Effect of fatty acids and their derivatives on mitochondrial structures.
Academic Article AMP-activated protein kinase signaling protects oligodendrocytes that restore central nervous system functions in an experimental autoimmune encephalomyelitis model.
Academic Article Histone deacetylase inhibitor upregulates peroxisomal fatty acid oxidation and inhibits apoptotic cell death in abcd1-deficient glial cells.
Academic Article Calcium-activated neutral proteinase in rat brain myelin and subcellular fractions.
Academic Article Phytanic acid alpha-oxidation in rat liver mitochondria.
Academic Article Antioxidant enzymes in ciprofibrate-induced oxidative stress.
Academic Article Peroxisomal participation in the cellular response to the oxidative stress of endotoxin.
Academic Article Visualization of multiple imidazoline/guanidinium-receptive sites.
Academic Article Thioridazine induces lipid peroxidation in myelin of rat brain.
Academic Article Purification of peroxisomes and subcellular distribution of enzyme activities for activation and oxidation of very-long-chain fatty acids in rat brain.
Academic Article Identification of phytanoyl-CoA ligase as a distinct acyl-CoA ligase in peroxisomes from cultured human skin fibroblasts.
Academic Article Peroxisomal activation, transport and oxidation of fatty acids: implications to peroxisomal disorders.
Academic Article Epoxide hydrolase in human and rat peroxisomes: implication for disorders of peroxisomal biogenesis.
Academic Article Topology of ATP-binding domain of adrenoleukodystrophy gene product in peroxisomes.
Academic Article Mammalian peroxisomes: metabolism of oxygen and reactive oxygen species.
Academic Article Modulation of endogenous antioxidant enzymes by nitric oxide in rat C6 glial cells.
Concept Disease Models, Animal
Concept Animals, Newborn
Concept Animals
Concept Behavior, Animal
Concept Models, Animal
Concept Animals, Suckling
Academic Article Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells.
Academic Article Cerulenin blockade of fatty acid synthase reverses hepatic steatosis in ob/ob mice.
Academic Article PPARa activation induces N(e)-Lys-acetylation of rat liver peroxisomal multifunctional enzyme type 1.
Academic Article STAT3 regulation by S-nitrosylation: implication for inflammatory disease.
Academic Article Effect of vitamin D3 intake on the onset of disease in a murine model of human Krabbe disease.
Academic Article S-Nitrosoglutathione protects the spinal bladder: novel therapeutic approach to post-spinal cord injury bladder remodeling.
Academic Article S-nitrosoglutathione prevents blood-brain barrier disruption associated with increased matrix metalloproteinase-9 activity in experimental diabetes.
Academic Article ABCD1 deletion-induced mitochondrial dysfunction is corrected by SAHA: implication for adrenoleukodystrophy.
Academic Article Role of S-nitrosoglutathione mediated mechanisms in tau hyper-phosphorylation.
Academic Article Promoting endothelial function by S-nitrosoglutathione through the HIF-1a/VEGF pathway stimulates neurorepair and functional recovery following experimental stroke in rats.
Academic Article Oral administration of cytosolic PLA2 inhibitor arachidonyl trifluoromethyl ketone ameliorates cauda equina compression injury in rats.
Academic Article Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapy.
Academic Article S-Nitrosoglutathione-mediated STAT3 regulation in efficacy of radiotherapy and cisplatin therapy in head and neck squamous cell carcinoma.
Academic Article S-nitrosoglutathione reduces tau hyper-phosphorylation and provides neuroprotection in rat model of chronic cerebral hypoperfusion.
Academic Article AKP-11 - A Novel S1P1 Agonist with Favorable Safety Profile Attenuates Experimental Autoimmune Encephalomyelitis in Rat Model of Multiple Sclerosis.
Academic Article Targeting the nNOS/peroxynitrite/calpain system to confer neuroprotection and aid functional recovery in a mouse model of TBI.
Academic Article Sex-specific effects of N-acetylcysteine in neonatal rats treated with hypothermia after severe hypoxia-ischemia.
Academic Article S-Nitrosoglutathione ameliorates acute renal dysfunction in a rat model of lipopolysaccharide-induced sepsis.
Academic Article MicroRNA Profiling Identifies miR-196a as Differentially Expressed in Childhood Adrenoleukodystrophy and Adult Adrenomyeloneuropathy.
Academic Article Biochemical, cell biological, pathological, and therapeutic aspects of Krabbe's disease.
Academic Article GSNO promotes functional recovery in experimental TBI by stabilizing HIF-1a.
Academic Article STAT3 Regulation By S-Nitrosylation: Implication In Cancer.
Academic Article Regulation of STAT3 and NF-?B activations by S-nitrosylation in multiple myeloma.
Academic Article Vitamin D improves functional outcomes in neonatal hypoxic ischemic male rats treated with N-acetylcysteine and hypothermia.
Academic Article Combination therapy of lovastatin and AMP-activated protein kinase activator improves mitochondrial and peroxisomal functions and clinical disease in experimental autoimmune encephalomyelitis model.
Academic Article S-nitrosoglutathione reductase (GSNOR) inhibitor as an immune modulator in experimental autoimmune encephalomyelitis.
Academic Article Pathology of nNOS-Expressing GABAergic Neurons in Mouse Model of Alzheimer's Disease.
Academic Article Protective effect of S-nitrosoglutathione administration against hyperglycemia induced disruption of blood brain barrier is mediated by modulation of tight junction proteins and cell adhesion molecules.
Academic Article Regulation of IL-10 and IL-17 mediated experimental autoimmune encephalomyelitis by S-nitrosoglutathione.
Academic Article Combined treatment with GSNO and CAPE accelerates functional recovery via additive antioxidant activities in a mouse model of TBI.
Academic Article Amelioration of spinal cord injury in rats by blocking peroxynitrite/calpain activity.
Academic Article S-Nitrosoglutathione Mimics the Beneficial Activity of Endothelial Nitric Oxide Synthase-Derived Nitric Oxide in a Mouse Model of Stroke.
Academic Article Peroxisomal footprint in the pathogenesis of nonalcoholic steatohepatitis.
Academic Article Detoxification of Reactive Aldehydes by Alda-1 Treatment Ameliorates Experimental Autoimmune Encephalomyelitis in Mice.
Academic Article GSNOR and ALDH2 alleviate traumatic spinal cord injury.
Academic Article Hypoxia-inducible factor-1 drives divergent immunomodulatory functions in the pathogenesis of autoimmune diseases.
Academic Article Investigation of S-Nitrosoglutathione in stroke: A systematic review and meta-analysis of literature in pre-clinical and clinical research.
Academic Article Asymmetric dimethylarginine exacerbates cognitive dysfunction associated with cerebrovascular pathology.
Academic Article Targeting GSNOR for functional recovery in a middle-aged mouse model of stroke.
Academic Article Regulation of B cell functions by S-nitrosoglutathione in the EAE model.
Academic Article Vascular and immunopathological role of Asymmetric Dimethylarginine (ADMA) in Experimental Autoimmune Encephalomyelitis.
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