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Smith, Charles
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Item TypeName
Academic Article Discovery and evaluation of inhibitors of human sphingosine kinase.
Academic Article Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis.
Academic Article Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase.
Academic Article PIM1 protein kinase regulates PRAS40 phosphorylation and mTOR activity in FDCP1 cells.
Academic Article Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells.
Academic Article A novel sphingosine kinase inhibitor induces autophagy in tumor cells.
Academic Article Combined anticancer effects of sphingosine kinase inhibitors and sorafenib.
Academic Article Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase.
Academic Article The Pim protein kinases regulate energy metabolism and cell growth.
Academic Article Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts.
Academic Article Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion.
Academic Article Ablation of sphingosine kinase-2 inhibits tumor cell proliferation and migration.
Academic Article Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats.
Academic Article Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
Academic Article A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma.
Academic Article Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2.
Academic Article Characterization of isoenzyme-selective inhibitors of human sphingosine kinases.
Academic Article Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.
Concept Mitogen-Activated Protein Kinases
Concept Protein Kinase Inhibitors
Concept src-Family Kinases
Concept Protein Kinases
Concept MAP Kinase Signaling System
Concept Phosphotransferases (Alcohol Group Acceptor)
Concept Extracellular Signal-Regulated MAP Kinases
Concept Cyclin-Dependent Kinase Inhibitor p27
Academic Article Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma.
Academic Article The Sphingosine Kinase 2 Inhibitor ABC294640 Reduces the Growth of Prostate Cancer Cells and Results in Accumulation of Dihydroceramides In Vitro and In Vivo.
Academic Article Tissue biomarkers of drug efficacy: case studies using a MALDI-MSI workflow.
Academic Article Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors.
Academic Article Combining nanoliposomal ceramide with sorafenib synergistically inhibits melanoma and breast cancer cell survival to decrease tumor development.
Academic Article Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma.
Academic Article Targeting NF?B mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2.
Academic Article Rapid histamine-induced neutrophil recruitment is sphingosine kinase-1 dependent.
Academic Article Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640.
Academic Article A Phase I Study of ABC294640, a First-in-Class Sphingosine Kinase-2 Inhibitor, in Patients with Advanced Solid Tumors.
Academic Article ABC294640, A Novel Sphingosine Kinase 2 Inhibitor, Induces Oncogenic Virus-Infected Cell Autophagic Death and Represses Tumor Growth.
Academic Article Antitumor effect of the novel sphingosine kinase 2 inhibitor ABC294640 is enhanced by inhibition of autophagy and by sorafenib in human cholangiocarcinoma cells.
Concept TOR Serine-Threonine Kinases
Academic Article Analysis of selective target engagement by small-molecule sphingosine kinase inhibitors using the Cellular Thermal Shift Assay (CETSA).
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  • Phosphotransferases