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Academic Article Importance of glutathione and associated enzymes in drug response.
Academic Article Coordinate changes in expression of protective genes in drug-resistant cells.
Academic Article Increased expression of DNA-dependent protein kinase confers resistance to adriamycin.
Academic Article Impact of dietary supplement of Crassostrea gigas extract (JCOE) on glutathione levels and glutathione S-transferase activity in rat tissues.
Academic Article Molecular conformation of estramustine and two analogues.
Academic Article ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter.
Academic Article Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione S-transferase.
Academic Article Glutathione conjugate interactions with DNA-dependent protein kinase.
Academic Article Role of redox potential and reactive oxygen species in stress signaling.
Academic Article Cellular response to a glutathione S-transferase P1-1 activated prodrug.
Academic Article Glutathione S-transferase p elicits protection against H2O2-induced cell death via coordinated regulation of stress kinases.
Academic Article Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus.
Academic Article Cloning and characterization of human adenosine 5'-triphosphate-binding cassette, sub-family A, transporter 2 (ABCA2).
Academic Article Gene expression profiling using a novel method: amplified differential gene expression (ADGE).
Academic Article Increased levels of glutathione S-transferase pi transcript as a mechanism of resistance to ethacrynic acid.
Academic Article Estrogens and environmental estrogens.
Academic Article Protein interaction-targeted drug discovery: evaluating critical issues.
Academic Article Polyphenols: do they play a role in the prevention of human pathologies?
Academic Article Binding of chlorozotocin and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea to chromatin and nucleosomal fractions of HeLa cells.
Academic Article Genomic sequence of human glyoxalase-I: analysis of promoter activity and its regulation.
Academic Article Glutathione peptidomimetic drug modulator of multidrug resistance-associated protein.
Academic Article Efficacy of a glutathione S-transferase pi-activated prodrug in platinum-resistant ovarian cancer cells.
Academic Article I. Arginine.
Academic Article The antioxidant role of selenium and seleno-compounds.
Academic Article Sensitivity and fidelity of DNA microarray improved with integration of Amplified Differential Gene Expression (ADGE).
Academic Article Molecular modes of action of artesunate in tumor cell lines.
Academic Article The role of glutathione-S-transferase in anti-cancer drug resistance.
Academic Article Sulfur containing amino acids and human disease.
Academic Article Amplified differential gene expression microarray.
Academic Article The role of carotenoids in the prevention of human pathologies.
Academic Article Small molecule inhibition of hypoxia inducible factor-1alpha: a viable therapeutic approach?
Academic Article Identification of a novel first exon of the human ABCA2 transporter gene encoding a unique N-terminus.
Academic Article Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug.
Academic Article Mitoxantrone resistance in a small cell lung cancer cell line is associated with ABCA2 upregulation.
Academic Article Organosulfur compounds from alliaceae in the prevention of human pathologies.
Academic Article Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density lipoprotein receptor expression and negatively regulates cholesterol esterification in Chinese hamster ovary cells.
Academic Article Enzymatic conjugation of chlorambucil with glutathione by human glutathione S-transferases and inhibition by ethacrynic acid.
Academic Article Influence of glutathione S-transferase pi and p53 expression on tumor frequency and spectrum in mice.
Academic Article Glutathione and ABC transporters as determinants of sensitivity to oxidative and nitrosative stress.
Academic Article Double high-dose chemotherapy with stem cell rescue (HD-SCR) in patients with breast cancer - effect of sequence.
Academic Article The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance.
Academic Article Evaluation of lipophilins as determinants of tumor cell response to estramustine.
Academic Article Glutathione S-transferases in normal and malignant human colon tissue.
Academic Article A glutathione S-transferase pi-activated prodrug causes kinase activation concurrent with S-glutathionylation of proteins.
Academic Article Detoxification mechanisms and tumor cell resistance to anticancer drugs.
Academic Article The ATP-binding cassette transporter ABCA2 as a mediator of intracellular trafficking.
Academic Article "Skittish" Abca2 knockout mice display tremor, hyperactivity, and abnormal myelin ultrastructure in the central nervous system.
Academic Article Interaction of forskolin with the P-glycoprotein multidrug transporter.
Academic Article Cellular thiols and reactive oxygen species in drug-induced apoptosis.
Academic Article Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs.
Academic Article ABCA2 as a therapeutic target in cancer and nervous system disorders.
Academic Article NOV-002, a glutathione disulfide mimetic, as a modulator of cellular redox balance.
Academic Article Protein cysteine sulfinic acid reductase (sulfiredoxin) as a regulator of cell proliferation and drug response.
Academic Article Pharmacology of a mimetic of glutathione disulfide, NOV-002.
Academic Article Depletion of glutathione in normal and malignant human cells in vivo by buthionine sulfoximine: clinical and biochemical results.
Academic Article Nitrosative stress-induced s-glutathionylation of protein disulfide isomerase leads to activation of the unfolded protein response.
Academic Article The spontaneous and glutathione S-transferase-mediated reaction of chlorambucil with glutathione.
Academic Article Preclinical pharmacokinetic analysis of NOV-002, a glutathione disulfide mimetic.
Academic Article The impact of redox and thiol status on the bone marrow: Pharmacological intervention strategies.
Academic Article Redox platforms in cancer drug discovery and development.
Academic Article Diazeniumdiolate mediated nitrosative stress alters nitric oxide homeostasis through intracellular calcium and S-glutathionylation of nitric oxide synthetase.
Academic Article S-glutathionylation: from molecular mechanisms to health outcomes.
Academic Article Regulatory functions of glutathione S-transferase P1-1 unrelated to detoxification.
Academic Article Immunohistochemical localization of glutathione S-transferases alpha, mu, and pi in normal tissue and carcinomas from human colon.
Academic Article Effect of 1-methyl-1-nitrosourea on poly(adenosine diphosphate-ribose) polymerase activity at the nucleosomal level.
Academic Article Nitrosourea interaction with chromatin and effect on poly(adenosine diphosphate ribose) polymerase activity.
Academic Article Cytotoxicity and DNA damaging effects of a new nitrosourea, fotemustine, diethyl- 1-(3-(2-chloroethyl)-3-nitrosoureido) ethylphosphonate-S10036.
Academic Article Glutathione, glutathione S-transferases, and related redox enzymes in Adriamycin-resistant cell lines with a multidrug resistant phenotype.
Academic Article Glutathione-s-transferases as determinants of cell survival and death.
Academic Article S-Glutathionylation of Protein Disulfide Isomerase Regulates Estrogen Receptor a Stability and Function.
Academic Article Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice.
Academic Article Oxidative processing of latent Fas in the endoplasmic reticulum controls the strength of apoptosis.
Academic Article Developmental expression of orphan G protein-coupled receptor 50 in the mouse brain.
Academic Article Allelic variants of glutathione S-transferase P1-1 differentially mediate the peroxidase function of peroxiredoxin VI and alter membrane lipid peroxidation.
Academic Article Identification of a glutathione S-transferase associated with microsomes of tumor cells resistant to nitrogen mustards.
Academic Article II. Glutamine and glutamate.
Academic Article Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors.
Academic Article Integration of amplified differential gene expression (ADGE) and DNA microarray.
Academic Article Mechanism based chemotherapy for prostate cancer.
Academic Article Resistance to phorbol 12-myristate 13-acetate-induced cell growth arrest in an HL60 cell line chronically exposed to a glutathione S-transferase pi inhibitor.
Academic Article Cancer drugs, genetic variation and the glutathione-S-transferase gene family.
Academic Article The importance of glutathione in human disease.
Academic Article Causes and consequences of cysteine S-glutathionylation.
Academic Article A comparative analysis of drug-induced DNA effects in a nitrogen mustard resistant cell line expressing sensitivity to nitrosoureas.
Academic Article Poly(adenosine diphosphate-ribosylation) of nuclear matrix proteins in alkylating agent resistant and sensitive cell lines.
Academic Article Differences in the nuclear matrix phosphoproteins of a wild-type and nitrogen mustard-resistant rat breast carcinoma cell line.
Academic Article Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines.
Academic Article Glutathione S-transferases in nitrogen mustard-resistant and -sensitive cell lines.
Academic Article Effects of cis-dichlorodiammine platinum (II) on DNA synthesis in kidney and other tissues of normal and tumour-bearing rats.
Academic Article Repair of DNA alkylation induced in L1210 leukemia and murine bone marrow by three chloroethylnitrosoureas.
Academic Article Biochemical and cytotoxic properties of the isomeric forms of N,N'-bis[N-2-chloroethyl)-N-nitrosocarbamoyl] cystamine.
Academic Article Phytosterols in the prevention of human pathologies.
Academic Article The effects of estramustine on metaphase and anaphase in DU 145 prostatic carcinoma cells.
Academic Article Modulation of detoxification gene expression in human colon HT29 cells by glutathione-S-transferase inhibitors.
Academic Article Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics.
Academic Article Time course of glutathione S-transferase elevation in Walker mammary carcinoma cells following chlorambucil exposure.
Academic Article Modulation of P-glycoprotein activity by estramustine is limited by binding to plasma proteins.
Academic Article Combined antimicrotubule activity of estramustine and taxol in human prostatic carcinoma cell lines.
Academic Article Interaction of an estramustine photoaffinity analogue with cytoskeletal proteins in prostate carcinoma cells.
Academic Article cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.
Academic Article Overproduction of a 37.5-kDa cytosolic protein structurally related to prostaglandin F synthase in ethacrynic acid-resistant human colon cells.
Academic Article Analysis of glyoxalase-I from normal and tumor tissue from human colon.
Academic Article Cloning and characterization of human colon glyoxalase-I.
Academic Article Interaction of estramustine with tubulin isotypes.
Academic Article Trace elements in human physiology and pathology. Copper.
Academic Article Trace elements in human physiology and pathology: zinc and metallothioneins.
Academic Article Increased myeloproliferation in glutathione S-transferase pi-deficient mice is associated with a deregulation of JNK and Janus kinase/STAT pathways.
Academic Article Resistance to the antimitotic drug estramustine is distinct from the multidrug resistant phenotype.
Academic Article Association of ABCA2 expression with determinants of Alzheimer's disease.
Academic Article Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid.
Academic Article Characterization of the ATPase activity of human ATP-binding cassette transporter-2 (ABCA2).
Academic Article TLK-286: a novel glutathione S-transferase-activated prodrug.
Academic Article Glutathione S-transferases as regulators of kinase pathways and anticancer drug targets.
Academic Article PABA/NO as an anticancer lead: analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity.
Academic Article Glutathione S-transferase polymorphisms: cancer incidence and therapy.
Academic Article A novel role for human sulfiredoxin in the reversal of glutathionylation.
Academic Article How is a conservative US administration influencing NCI funding?
Academic Article Determinants of drug response in a cisplatin-resistant human lung cancer cell line.
Academic Article Redox in redux: Emergent roles for glutathione S-transferase P (GSTP) in regulation of cell signaling and S-glutathionylation.
Academic Article The ABCA2 transporter: intracellular roles in trafficking and metabolism of LDL-derived cholesterol and sterol-related compounds.
Academic Article NOV-002, a mimetic of glutathione disulfide.
Academic Article Role of glutathione S-transferase Pi in cisplatin-induced nephrotoxicity.
Academic Article Novel role for glutathione S-transferase pi. Regulator of protein S-Glutathionylation following oxidative and nitrosative stress.
Academic Article Characterization of glutathione S-transferase expression in lymphocytes from chronic lymphocytic leukemia patients.
Academic Article Modification of L1210 cell nuclear proteins by 1-methyl-1-nitrosourea and 1-methyl-3-nitro-1-nitrosoguanidine.
Academic Article Protective effects of a glutathione disulfide mimetic (NOV-002) against cisplatin induced kidney toxicity.
Academic Article Glutathione-S-transferase pi as a determinant of drug resistance in transfectant cell lines.
Academic Article Cellular resistance to a nitric oxide releasing glutathione S-transferase P-activated prodrug, PABA/NO.
Academic Article Glutathione S-transferases in human prostate.
Academic Article Redox metabolism and malignancy.
Academic Article ABCA2 transporter deficiency reduces incidence of TRAMP prostate tumor metastasis and cellular chemotactic migration.
Academic Article The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer.
Academic Article Cocaine-induced adaptations in cellular redox balance contributes to enduring behavioral plasticity.
Academic Article Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-? production by altering Nicastrin maturation and intracellular localization.
Academic Article Drug resistance in cancer. Editorial.
Academic Article NrF2 /Keap1 as gatekeepers of redox homeostasis ? do they prevent or cause cancer?
Academic Article S-glutathionylated serine proteinase inhibitors as plasma biomarkers in assessing response to redox-modulating drugs.
Academic Article Intracellular effects of estramustine (Estracyt/Emcyt).
Academic Article Estramustine--a nitrogen mustard/steroid with antimicrotubule activity.
Academic Article Ablation of the ATP-binding cassette transporter, Abca2 modifies response to estrogen-based therapies.
Academic Article Sulfiredoxin redox-sensitive interaction with S100A4 and non-muscle myosin IIA regulates cancer cell motility.
Academic Article Estramustine binds a MAP-1-like protein to inhibit microtubule assembly in vitro and disrupt microtubule organization in DU 145 cells.
Academic Article Estramustine binds MAP-2 to inhibit microtubule assembly in vitro.
Academic Article Purification of glutathione S-transferases from rat liver and Walker 256 mammary carcinoma cells by high-performance liquid chromatography and a glutathione affinity column.
Academic Article Selection of nitrogen mustard resistance in a rat tumor cell line results in loss of guanine-O6-alkyl transferase activity.
Academic Article Relationship of glutathione depletion and inhibition of glutathione-S-transferase activity to the antimitotic properties of estramustine.
Academic Article Dansylated estramustine, a fluorescent probe for studies of estramustine uptake and identification of intracellular targets.
Academic Article Mechanism of action of 2-haloethylnitrosoureas on deoxyribonucleic acid. Pathways of aqueous decomposition and pharmacological characteristics of new anticancer disulfide-linked nitrosoureas.
Academic Article Carbamoylation of glutathione reductase and changes in cellular and chromosome morphology in a rat cell line resistant to nitrogen mustards but collaterally sensitive to nitrosoureas.
Academic Article Antimicrotubule effects of estramustine, an antiprostatic tumor drug.
Academic Article Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards.
Academic Article Alkylating agent interactions with the nuclear matrix.
Academic Article The mechanism of action of estramustine.
Academic Article Cytotoxic properties of estramustine unrelated to alkylating and steroid constituents.
Academic Article Cytotoxicity of estramustine, a steroid-nitrogen mustard derivative, through non-DNA targets.
Academic Article Selective cytotoxicity of haloethylnitrosoureas in a carcinoma cell line resistant to bifunctional nitrogen mustards.
Academic Article Influence of hydrocortisone on the binding of nitrosoureas to nuclear chromatin subfractions.
Academic Article Pharmakokinetics and bioavailability study of ethacrynic acid as a modulator of drug resistance in patients with cancer.
Academic Article Glutathione-associated enzymes in anticancer drug resistance.
Academic Article Effects of chronic ethacrynic acid exposure on glutathione conjugation and MRP expression in human colon tumor cells.
Academic Article Cellular and in vitro transport of glutathione conjugates by MRP.
Academic Article Increase of beta(III)- and beta(IVa)-tubulin isotopes in human prostate carcinoma cells as a result of estramustine resistance.
Academic Article Adaptive response to glutathione S-transferase inhibitors.
Academic Article Promoter analysis of a human dihydrodiol dehydrogenase.
Concept NADP
Concept Journal Impact Factor
Concept Cytokines
Concept Glutamine
Concept Blotting, Southern
Concept Inactivation, Metabolic
Concept Insulin
Concept Financing, Government
Concept Methylnitronitrosoguanidine
Concept Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase
Concept Epithelial Cells
Concept Enzyme-Linked Immunosorbent Assay
Concept Poly Adenosine Diphosphate Ribose
Concept Age Factors
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Concept Intestinal Mucosa
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Concept Hydroxylation
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Concept Tumor Suppressor Protein p53
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Concept Drug Evaluation, Preclinical
Concept Hep G2 Cells
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Concept Cyclin-Dependent Kinase Inhibitor p57
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Concept Carcinoma 256, Walker
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Concept Promoter Regions, Genetic
Concept Epoxy Compounds
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Concept Mechlorethamine
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Concept Leukemia, Lymphocytic, Chronic, B-Cell
Concept Fluorescent Antibody Technique, Indirect
Concept Vimentin
Concept Cyclic AMP
Concept Base Sequence
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Concept Immunohistochemistry
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Concept Vinblastine
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Concept Molecular Sequence Data
Concept Hypoxia-Inducible Factor 1, alpha Subunit
Concept Antibiotics, Antineoplastic
Concept Anthracenes
Concept Sexual Dysfunction, Physiological
Concept Immunoblotting
Concept Diethylstilbestrol
Concept Guanosine Diphosphate
Concept Chemokine CXCL12
Concept Glucose
Academic Article Peroxiredoxin VI oxidation in cerebrospinal fluid correlates with traumatic brain injury outcome.
Academic Article Pleiotropic functions of glutathione S-transferase P.
Academic Article Glutathione S-transferase P influences redox and migration pathways in bone marrow.
Academic Article Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its D,L-polylactide microparticle formulation.
Academic Article Oxidative stress, redox regulation and diseases of cellular differentiation.
Academic Article Editor's Note.
Academic Article S-glutathionylation of buccal cell proteins as biomarkers of exposure to hydrogen peroxide.
Academic Article Adverse Outcomes Associated with Cigarette Smoke Radicals Related to Damage to Protein-disulfide Isomerase.
Academic Article Glutathione-Associated Enzymes In Anticancer Drug Resistance.
Academic Article Glutathione S-transferase pi modulates NF-?B activation and pro-inflammatory responses in lung epithelial cells.
Academic Article Chemical Reactivity Window Determines Prodrug Efficiency toward Glutathione Transferase Overexpressing Cancer Cells.
Academic Article Redox Signaling and Bioenergetics Influence Lung Cancer Cell Line Sensitivity to the Isoflavone ME-344.
Academic Article Redox pathways in cancer drug discovery.
Academic Article Glutathione S-Transferase P-Mediated Protein S-Glutathionylation of Resident Endoplasmic Reticulum Proteins Influences Sensitivity to Drug-Induced Unfolded Protein Response.
Academic Article Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase p.
Academic Article Commentary on "Proteasome Inhibitors: A Novel Class of Potent and Effective Antitumor Agents".
Academic Article Glutathione S-transferases as emerging therapeutic targets.
Academic Article MYC Inhibition Depletes Cancer Stem-like Cells in Triple-Negative Breast Cancer.
Academic Article Selenocompounds in Cancer Therapy: An Overview.
Academic Article Preface.
Academic Article ATP-binding cassette transporter-2 (ABCA2) as a therapeutic target.
Academic Article S-Glutathionylation of estrogen receptor a affects dendritic cell function.
Academic Article An evolving understanding of the S-glutathionylation cycle in pathways of redox regulation.
Academic Article MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation.
Academic Article Pharmacology of ME-344, a novel cytotoxic isoflavone.
Academic Article A seleno-hormetine protects bone marrow hematopoietic cells against ionizing radiation-induced toxicities.
Academic Article Oxidative stress induces senescence in breast cancer stem cells.
Academic Article Isoflavone ME-344 Disrupts Redox Homeostasis and Mitochondrial Function by Targeting Heme Oxygenase 1.
Academic Article Racial disparities, cancer and response to oxidative stress.
Academic Article S-Glutathionylated Serine Proteinase Inhibitors as Biomarkers for Radiation Exposure in Prostate Cancer Patients.
Academic Article Nrf2-modulation by seleno-hormetic agents and its potential for radiation protection.
Academic Article Altered redox regulation and S-glutathionylation of BiP contribute to bortezomib resistance in multiple myeloma.
Academic Article Glutathione S-Transferase P Influences Redox Homeostasis and Response to Drugs that Induce the Unfolded Protein Response in Zebrafish.
Academic Article Nrf2 inhibition sensitizes breast cancer stem cells to ionizing radiation via suppressing DNA repair.
Academic Article Voltage-Dependent Anion Channels Influence Cytotoxicity of ME-344, a Therapeutic Isoflavone.
Academic Article Oxidative Stress in Cancer.
Academic Article Development of Telintra as an Inhibitor of Glutathione S-Transferase P.
Academic Article Nuclear PFKP promotes CXCR4-dependent infiltration by T cell acute lymphoblastic leukemia.
Concept Transcriptome
Concept Endoplasmic Reticulum Stress
Concept MCF-7 Cells
Concept para-Aminobenzoates
Concept Hydroxybenzoates
Concept NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases
Concept In Vitro Techniques
Concept Copper-transporting ATPases
Concept Radiation Exposure
Concept Bortezomib
Concept Ku Autoantigen
Concept HEK293 Cells
Academic Article Cisplatin chemotherapy and renal function.
Academic Article Reductive stress in cancer.
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