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Importance of glutathione and associated enzymes in drug response.
Coordinate changes in expression of protective genes in drug-resistant cells.
Increased levels of glutathione S-transferase pi transcript as a mechanism of resistance to ethacrynic acid.
Enzymatic conjugation of chlorambucil with glutathione by human glutathione S-transferases and inhibition by ethacrynic acid.
Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines.
Modulation of detoxification gene expression in human colon HT29 cells by glutathione-S-transferase inhibitors.
Influence of ethacrynic acid on glutathione S-transferase pi transcript and protein half-lives in human colon cancer cells.
Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics.
Modulation of glutathione and related enzymes in reversal of resistance to anticancer drugs.
cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.
Overproduction of a 37.5-kDa cytosolic protein structurally related to prostaglandin F synthase in ethacrynic acid-resistant human colon cells.
Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid.
Pharmakokinetics and bioavailability study of ethacrynic acid as a modulator of drug resistance in patients with cancer.
Effects of chronic ethacrynic acid exposure on glutathione conjugation and MRP expression in human colon tumor cells.
Adaptive response to glutathione S-transferase inhibitors.