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Tomlinson, Stephen
One or more keywords matched the following items that are connected to Tomlinson, Stephen
Item TypeName
Academic Article Targeting of functional antibody-decay-accelerating factor fusion proteins to a cell surface.
Academic Article A tumor-expressed inhibitor of the early but not late complement lytic pathway enhances tumor growth in a rat model of human breast cancer.
Academic Article Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation.
Academic Article Complement function in mAb-mediated cancer immunotherapy.
Academic Article Mouse complement receptor-related gene y/p65-neutralized tumor vaccine induces antitumor activity in vivo.
Academic Article Complement inhibitors targeted to the proximal tubule prevent injury in experimental nephrotic syndrome and demonstrate a key role for C5b-9.
Academic Article Insights into the human CD59 complement binding interface toward engineering new therapeutics.
Academic Article Combined therapeutic use of AdGFPFasL and small molecule inhibitors of ceramide metabolism in prostate and head and neck cancers: a status report.
Academic Article Complement plays an important role in spinal cord injury and represents a therapeutic target for improving recovery following trauma.
Academic Article A novel targeted inhibitor of the alternative pathway of complement and its therapeutic application in ischemia/reperfusion injury.
Academic Article App1: an antiphagocytic protein that binds to complement receptors 3 and 2.
Academic Article A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration.
Academic Article A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice.
Academic Article Complement-dependent inflammation and injury in a murine model of brain dead donor hearts.
Academic Article Targeted inhibition of the complement alternative pathway with complement receptor 2 and factor H attenuates collagen antibody-induced arthritis in mice.
Academic Article Macrophage-produced IL-12p70 mediates hemorrhage-induced damage in a complement-dependent manner.
Academic Article A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration.
Academic Article Complement regulates TLR4-mediated inflammatory responses during intestinal ischemia reperfusion.
Academic Article The alternative and terminal pathways of complement mediate post-traumatic spinal cord inflammation and injury.
Academic Article The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization.
Academic Article Complement inhibition alleviates paraquat-induced acute lung injury.
Academic Article CD4+ T cells and complement independently mediate graft ischemia in the rejection of mouse orthotopic tracheal transplants.
Academic Article The dual role of complement in the progression of renal disease in NZB/W F(1) mice and alternative pathway inhibition.
Academic Article A targeted complement-dependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer.
Academic Article Oval cell response is attenuated by depletion of liver resident macrophages in the 2-AAF/partial hepatectomy rat.
Academic Article The C5 convertase is not required for activation of the terminal complement pathway in murine experimental cerebral malaria.
Academic Article The alternative complement pathway propagates inflammation and injury in murine ischemic stroke.
Academic Article Targeting complement component 5a promotes vascular integrity and limits airway remodeling.
Academic Article Upregulation of the d opioid receptor in liver cancer promotes liver cancer progression both in vitro and in vivo.
Academic Article The effect of dexamethasone on human mucin 1 expression and antibody-dependent complement sensitivity in a prostate cancer cell line in vitro and in vivo.
Academic Article A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.
Academic Article Inhibition of a complement regulator in vivo enhances antibody therapy in a model of mammary adenocarcinoma.
Academic Article Targeted complement inhibition by C3d recognition ameliorates tissue injury without apparent increase in susceptibility to infection.
Academic Article Complement-mediated mechanisms in anti-GD2 monoclonal antibody therapy of murine metastatic cancer.
Academic Article Interference with the complement system by tumor cell membrane type-1 matrix metalloproteinase plays a significant role in promoting metastasis in mice.
Academic Article Complement-dependent P-selectin expression and injury following ischemic stroke.
Academic Article Enhancement of antibody-dependent mechanisms of tumor cell lysis by a targeted activator of complement.
Academic Article A complement C3 inhibitor specifically targeted to sites of complement activation effectively ameliorates collagen-induced arthritis in DBA/1J mice.
Academic Article Low-dose targeted complement inhibition protects against renal disease and other manifestations of autoimmune disease in MRL/lpr mice.
Academic Article Effects of active and inactive phospholipase D2 on signal transduction, adhesion, migration, invasion, and metastasis in EL4 lymphoma cells.
Academic Article Modulation of protective T cell immunity by complement inhibitor expression on tumor cells.
Academic Article A role for complement in the enhanced susceptibility of steatotic livers to ischemia and reperfusion injury.
Academic Article Ketamine-xylazine-acepromazine compared with isoflurane for anesthesia during liver transplantation in rodents.
Academic Article A new therapeutic strategy for lung tissue injury induced by influenza with CR2 targeting complement inhibitor.
Academic Article Targeted inhibition of complement activation prevents features of preeclampsia in mice.
Academic Article Targeted complement inhibitors protect against posttransplant cardiac ischemia and reperfusion injury and reveal an important role for the alternative pathway of complement activation.
Academic Article The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice.
Academic Article Mapping the intermedilysin-human CD59 receptor interface reveals a deep correspondence with the binding site on CD59 for complement binding proteins C8alpha and C9.
Academic Article Binding of factor H to tubular epithelial cells limits interstitial complement activation in ischemic injury.
Academic Article Complement and the alternative pathway play an important role in LPS/D-GalN-induced fulminant hepatic failure.
Academic Article The critical role of complement alternative pathway regulator factor H in allergen-induced airway hyperresponsiveness and inflammation.
Academic Article Pathogenic natural antibodies propagate cerebral injury following ischemic stroke in mice.
Academic Article Complement-dependent injury and protection in a murine model of acute dextran sulfate sodium-induced colitis.
Academic Article A new treatment for neurogenic inflammation caused by EV71 with CR2-targeted complement inhibitor.
Academic Article CR2-mediated targeting of complement inhibitors: bench-to-bedside using a novel strategy for site-specific complement modulation.
Academic Article Donor brain death exacerbates complement-dependent ischemia/reperfusion injury in transplanted hearts.
Academic Article Inhibition of complement activation alleviates acute lung injury induced by highly pathogenic avian influenza H5N1 virus infection.
Academic Article Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway.
Concept Disease Models, Animal
Concept Animals, Newborn
Concept Animals
Concept Mammary Neoplasms, Animal
Concept Physical Conditioning, Animal
Concept Models, Animal
Academic Article Targeted inhibition of complement using complement receptor 2-conjugated inhibitors attenuates EAE.
Academic Article The complement regulatory protein CD59: insights into attenuation of choroidal neovascularization.
Academic Article Targeted mouse complement inhibitor CR2-Crry protects against the development of atherosclerosis in mice.
Academic Article A novel protocol allowing oral delivery of a protein complement inhibitor that subsequently targets to inflamed colon mucosa and ameliorates murine colitis.
Academic Article Complement-dependent modulation of antitumor immunity following radiation therapy.
Academic Article Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy.
Academic Article Reduction of myeloid-derived suppressor cells and lymphoma growth by a natural triterpenoid.
Academic Article New therapeutic and diagnostic opportunities for injured tissue-specific targeting of complement inhibitors and imaging modalities.
Academic Article A Targeted Inhibitor of the Alternative Complement Pathway Accelerates Recovery From Smoke-Induced Ocular Injury.
Academic Article Modulation of post-stroke degenerative and regenerative processes and subacute protection by site-targeted inhibition of the alternative pathway of complement.
Academic Article IL-1a and complement cooperate in triggering local neutrophilic inflammation in response to adenovirus and eliminating virus-containing cells.
Academic Article Regulation of the alternative pathway of complement modulates injury and immunity in a chronic model of dextran sulphate sodium-induced colitis.
Academic Article A new mouse anti-mouse complement receptor type 2 and 1 (CR2/CR1) monoclonal antibody as a tool to study receptor involvement in chronic models of immune responses and disease.
Academic Article Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury.
Academic Article Early Application of Auxiliary Partial Orthotopic Liver Transplantation in Murine Model of Wilson Disease.
Academic Article Prevention of Defective Placentation and Pregnancy Loss by Blocking Innate Immune Pathways in a Syngeneic Model of Placental Insufficiency.
Academic Article Complementing regeneration.
Academic Article Thromboembolic Model of Cerebral Ischemia and Reperfusion in Mice.
Academic Article Surface Expression of TGF? Docking Receptor GARP Promotes Oncogenesis and Immune Tolerance in Breast Cancer.
Academic Article Natural immunoglobulin M initiates an inflammatory response important for both hepatic ischemia reperfusion injury and regeneration in mice.
Academic Article Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement.
Academic Article Targeted Complement Inhibition Protects Vascularized Composite Allografts From Acute Graft Injury and Prolongs Graft Survival When Combined With Subtherapeutic Cyclosporine A Therapy.
Academic Article Aberrant JMJD3 Expression Upregulates Slug to Promote Migration, Invasion, and Stem Cell-Like Behaviors in Hepatocellular Carcinoma.
Academic Article Injury site-specific targeting of complement inhibitors for treating stroke.
Academic Article New Insights on Complement Inhibitor CD59 in Mouse Laser-Induced Choroidal Neovascularization: Mislocalization After Injury and Targeted Delivery for Protein Replacement.
Academic Article Preclinical and Clinical Evidence on Ipsilateral Corticospinal Projections: Implication for Motor Recovery.
Academic Article Identifying the Role of Complement in Triggering Neuroinflammation after Traumatic Brain Injury.
Academic Article C3a receptor antagonism as a novel therapeutic target for chronic rhinosinusitis.
Academic Article Targeted complement inhibition salvages stressed neurons and inhibits neuroinflammation after stroke in mice.
Academic Article Acute Complement Inhibition Potentiates Neurorehabilitation and Enhances tPA-Mediated Neuroprotection.
Academic Article Pharmacological Stimulation of Mitochondrial Biogenesis Using the Food and Drug Administration-Approved ?2-Adrenoreceptor Agonist Formoterol for the Treatment of Spinal Cord Injury.
Academic Article Sialic acid is a critical fetal defense against maternal complement attack.
Academic Article Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells.
Academic Article Acid sphingomyelinase deficiency protects mitochondria and improves function recovery after brain injury.
Academic Article CBX8 exhibits oncogenic properties and serves as a prognostic factor in hepatocellular carcinoma.
Academic Article Inhibition of the alternative complement pathway accelerates repair processes in the murine model of choroidal neovascularization.
Academic Article Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis.
Academic Article Complement C3-Targeted Gene Therapy Restricts Onset and Progression of Neurodegeneration in Chronic Mouse Glaucoma.
Academic Article Targeting the Complement Alternative Pathway Permits Graft Versus Leukemia Activity while Preventing Graft Versus Host Disease.
Academic Article Anti-inflammatory and Neuroprotective Agents in Clinical Trials for CNS Disease and Injury: Where Do We Go From Here?
Academic Article C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice.
Academic Article Complement Drives Synaptic Degeneration and Progressive Cognitive Decline in the Chronic Phase after Traumatic Brain Injury.
Academic Article Complement-Mediated Microglial Phagocytosis and Pathological Changes in the Development and Degeneration of the Visual System.
Academic Article A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury.
Academic Article Natural immunoglobulin M-based delivery of a complement alternative pathway inhibitor in mouse models of retinal degeneration.
Academic Article Complement mediates neuroinflammation and cognitive decline at extended chronic time points after traumatic brain injury.
Academic Article Complement-Dependent Synaptic Uptake and Cognitive Decline after Stroke and Reperfusion Therapy.
Academic Article Chronic complement dysregulation drives neuroinflammation after traumatic brain injury: a transcriptomic study.
Academic Article In Situ Pre-Treatment of Vascularized Composite Allografts With a Targeted Complement Inhibitor Protects Against Brain Death and Ischemia Reperfusion Induced Injuries.
Academic Article Modulation of the Complement System by Neoplastic Disease of the Central Nervous System.
Academic Article Increasing the efficacy and safety of a human complement inhibitor for treating post-transplant cardiac ischemia reperfusion injury by targeting to a graft-specific neoepitope.
Academic Article Characterization of Novel P-Selectin Targeted Complement Inhibitors in Murine Models of Hindlimb Injury and Transplantation.
Academic Article Complement Inhibition Alleviates Cholestatic Liver Injury Through Mediating Macrophage Infiltration and Function in Mice.
Academic Article A Role of Complement in the Pathogenic Sequelae of Mouse Neonatal Germinal Matrix Hemorrhage.
Academic Article Crosstalk between pro-survival sphingolipid metabolism and complement signaling induces inflammasome-mediated tumor metastasis.
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