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Glioma cell extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147) stimulates production of membrane-type matrix metalloproteinases and activated gelatinase A in co-cultures with brain-derived fibroblasts.
Active site residues of cyclophilin A are crucial for its signaling activity via CD147.
Basigin (murine EMMPRIN) stimulates matrix metalloproteinase production by fibroblasts.
CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A.