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One or more keywords matched the following properties of Trantham-Davidson, Heather
overview Dr. Davidson's research is focused on understanding the effects of adolescent alcohol exposure on development of the prefrontal cortex and how these changes impact cognitive function in adulthood. Recent work from her group has shown that exposure to alcohol during adolescence results in cognitive impairments that persist well into adulthood. Her current studies involve examining the effects of adolescent binge-like exposure to alcohol on prefrontal projections to specific subcortical structures. Early studies have shown an overall loss of D1 receptor modulation of prefrontal activity but dopamine may exert pathway specific effects on cortical circuits and current studies are aimed at elucidating the cellular pathways that are affected by adolescent exposure to alcohol and relating these changes to deficits in cognitive function that would impact decison making and risky behavior.
One or more keywords matched the following items that are connected to Trantham-Davidson, Heather
Item TypeName
Academic Article Repeated cocaine administration alters the electrophysiological properties of prefrontal cortical neurons.
Academic Article Ethanol reduces neuronal excitability of lateral orbitofrontal cortex neurons via a glycine receptor dependent mechanism.
Academic Article Mechanisms underlying differential D1 versus D2 dopamine receptor regulation of inhibition in prefrontal cortex.
Academic Article Dopamine modulation of prefrontal cortex interneurons occurs independently of DARPP-32.
Academic Article Up-regulation of calcyon results in locomotor hyperactivity and reduced anxiety in mice.
Academic Article Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice.
Academic Article Reduced dysbindin expression mediates N-methyl-D-aspartate receptor hypofunction and impaired working memory performance.
Concept Prefrontal Cortex
Academic Article Chronic alcohol disrupts dopamine receptor activity and the cognitive function of the medial prefrontal cortex.
Academic Article Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex.
Academic Article Alcohol-induced alterations in dopamine modulation of prefrontal activity.
Academic Article Binge-Like Alcohol Exposure During Adolescence Disrupts Dopaminergic Neurotransmission in the Adult Prelimbic Cortex.
Academic Article Loss of dysbindin-1 affects GABAergic transmission in the PFC.
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  • Prefrontal Cortex