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Novel methodologic approaches to phase I, II, and III trials.
High dose deferoxamine in intracerebral hemorrhage (HI-DEF) trial: rationale, design, and methods.
Effects of gender and cigarette smoking on reactivity to psychological and pharmacological stress provocation.
Designing clinical trials for dystonia.
Challenges of decision making regarding futility in a randomized trial: the Interventional Management of Stroke III experience.
Evolution of practice during the Interventional Management of Stroke III Trial and implications for ongoing trials.
A likelihood-based approach for computing the operating characteristics of the 3+3 phase I clinical trial design with extensions to other A+B designs.
The impact of covariate adjustment at randomization and analysis for binary outcomes: understanding differences between superiority and noninferiority?trials.
Power of an Adaptive Trial Design for Endovascular Stroke Studies: Simulations Using IMS (Interventional Management of Stroke) III Data.
Towards personalised intra-arterial treatment of patients with acute ischaemic stroke: a study protocol for development and validation of a clinical decision aid.
An adaptive clinical trial design to identify the target dose of tenecteplase for treatment of acute pulmonary embolism.