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Bartee, Eric
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overview Dr. Bartee's research interests involve the study of virus-host interactions with particular focus on how these interactions can be used to improve therapy for cancer patients. He is interested in the study of a rabbit-specific poxvirus called myxoma virus and how it interacts with normal and cancerous hematopoietic cells. He is currently exploring whether the virus can be used as a frontline therapy to improve treatment of myeloma patients by directly identifying and eliminating myeloma in vivo, eliminating residual myeloma after chemotherapy or expelling myeloma from its protected bone marrow niches.
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Academic Article Myxoma and vaccinia viruses exploit different mechanisms to enter and infect human cancer cells.
Academic Article Virotherapy using myxoma virus prevents lethal graft-versus-host disease following xeno-transplantation with primary human hematopoietic stem cells.
Academic Article Myxoma and vaccinia viruses bind differentially to human leukocytes.
Academic Article The poxviral RING protein p28 is a ubiquitin ligase that targets ubiquitin to viral replication factories.
Academic Article RIG-I mediates the co-induction of tumor necrosis factor and type I interferon elicited by myxoma virus in primary human macrophages.
Academic Article The addition of tumor necrosis factor plus beta interferon induces a novel synergistic antiviral state against poxviruses in primary human fibroblasts.
Academic Article Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumor necrosis factor plus interferon-beta.
Academic Article Acute myeloid leukemia targeting by myxoma virus in vivo depends on cell binding but not permissiveness to infection in vitro.
Academic Article Selective purging of human multiple myeloma cells from autologous stem cell transplantation grafts using oncolytic myxoma virus.
Concept Myxoma virus
Academic Article Myxoma Virus Induces Ligand Independent Extrinsic Apoptosis in Human Myeloma Cells.
Academic Article Myxoma virus attenuates expression of activating transcription factor 4 (ATF4) which has implications for the treatment of proteasome inhibitor-resistant multiple myeloma.
Academic Article Systemic therapy with oncolytic myxoma virus cures established residual multiple myeloma in mice.
Academic Article Refinement and Successful Implementation of a Scoring System for Myxomatosis in a Susceptible Rabbit (Oryctolagus cuniculus) Model.
Academic Article Oncolytic myxoma virus synergizes with standard of care for treatment of glioblastoma multiforme.
Academic Article Impact of Induced Syncytia Formation on the Oncolytic Potential of Myxoma Virus.
Academic Article Decreasing the Susceptibility of Malignant Cells to Infection Does Not Impact the Overall Efficacy of Myxoma Virus-Based Oncolytic Virotherapy.
Academic Article Initial dose of oncolytic myxoma virus programs durable antitumor immunity independent of in vivo viral replication.
Academic Article TNF blockade enhances the efficacy of myxoma virus-based oncolytic virotherapy.
Academic Article High Levels of Extracellular Potassium Can Delay Myxoma Virus Replication by Preventing Release of Virions from the Endosomes.
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  • Myxoma