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Biochemical inhibition of the acetyltransferases ATase1 and ATase2 reduces ß-secretase (BACE1) levels and Aß generation.
AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability.
Amyloid beta-Protein Precursor
Amyloid Precursor Protein Secretases
The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism.
Serum Amyloid A Protein