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overview
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Efforts in the Dolloff Laboratory are aimed at discovering and developing new targeted therapies for the treatment of incurable hematologic malignancies. The primary disease focus is Multiple Myeloma (MM) with a general interest in cytogenetically related B and plasma cell cancers that include non-Hodgkins Lymphoma, plasma cell leukemia, and others. Major objectives of the lab are to identify and validate new molecular targets and establish high throughput drug screening assays for screening large chemical libraries. Lead compounds that are discovered are then used as tools to better understand the biology of new targets and/or are selected for further drug development toward the ultimate goal of clinical translation.
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Dolloff, Nathan