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Guanine Nucleotide Exchange Factors
The Rho guanine nucleotide exchange factor Syx regulates the balance of dia and ROCK activities to promote polarized-cancer-cell migration.
TEM4 is a junctional Rho GEF required for cell-cell adhesion, monolayer integrity and barrier function.
Phosphorylation-mediated 14-3-3 protein binding regulates the function of the rho-specific guanine nucleotide exchange factor (RhoGEF) Syx.
VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx.
Rho Guanine Nucleotide Exchange Factors