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Interleukin-12 gene transfer results in CD8-dependent regression of murine CT26 liver tumors.
Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1beta converting enzyme cDNA.
Interleukin 12 gene transfer into skin distant from the tumor site elicits antimetastatic effects equivalent to local gene transfer.
B7.1 expression eliminates tumor resistance to IL-12 gene therapy.
Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine model.
Safety of interleukin-12 gene therapy against cancer: a murine biodistribution and toxicity study.
IL-12 cDNA direct injection: antimetastatic effect from a single injection in a murine hepatic metastases model.
Intratumoral injection of IL-12 plasmid DNA--results of a phase I/IB clinical trial.