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Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.
DNA damage invokes mismatch repair-dependent cyclin D1 attenuation and retinoblastoma signaling pathways to inhibit CDK2.
E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.
G2 Phase Cell Cycle Checkpoints