Item Type | Name |
Concept
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Tumor Cells, Cultured
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Concept
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Cells, Cultured
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Academic Article
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The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo.
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Academic Article
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Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes.
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Academic Article
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Activation of MDR1 (P-glycoprotein) gene expression in human cells by protein kinase C agonists.
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Academic Article
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Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells.
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Academic Article
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Analysis of gene amplification in human tumor cells by in-gel DNA renaturation assay.
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Academic Article
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Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line.
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Academic Article
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An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene.
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Academic Article
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Detection of amplified sequences in mammalian DNA by in-gel renaturation and SINE hybridization.
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Academic Article
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Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells.
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Academic Article
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Decreased expression of the amplified mdr1 gene in revertants of multidrug-resistant human myelogenous leukemia K562 occurs without loss of amplified DNA.
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Academic Article
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Multidrug resistance of DNA-mediated transformants is linked to transfer of the human mdr1 gene.
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Academic Article
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Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs.
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Academic Article
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Variable effects of sodium butyrate on the expression and function of the MDR1 (P-glycoprotein) gene in colon carcinoma cell lines.
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Academic Article
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Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein.
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Academic Article
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Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA.
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Academic Article
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Involvement of MDR1 P-glycoprotein in multifactorial resistance to methotrexate.
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Academic Article
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Monoclonal antibodies against P-glycoprotein, an MDR1 gene product, inhibit interleukin-2 release from PHA-activated lymphocytes.
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Academic Article
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Inhibition of cytarabine-induced MDR1 (P-glycoprotein) gene activation in human tumor cells by fatty acid-polyethylene glycol-fatty acid diesters, novel inhibitors of P-glycoprotein function.
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Academic Article
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Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis.
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Academic Article
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Identification of p53 genetic suppressor elements which confer resistance to cisplatin.
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Academic Article
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60-Hz electric fields inhibit protein kinase C activity and multidrug resistance gene (MDR1) up-regulation.
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Academic Article
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Efficient recovery and regeneration of integrated retroviruses.
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Academic Article
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P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity.
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Academic Article
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Drug resistance conferred by MDR1 expression in spheroids formed by glioblastoma cell lines.
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Academic Article
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Applications of green fluorescent protein as a marker of retroviral vectors.
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Academic Article
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Altered expression of ubiquitous kinesin heavy chain results in resistance to etoposide and hypersensitivity to colchicine: mapping of the domain associated with drug response.
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Academic Article
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Activation of the LRP (lung resistance-related protein) gene by short-term exposure of human leukemia cells to phorbol ester and cytarabine.
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Academic Article
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Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells.
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Academic Article
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Identification of potential anticancer drug targets through the selection of growth-inhibitory genetic suppressor elements.
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Academic Article
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p21(Waf1/Cip1/Sdi1) mediates retinoblastoma protein degradation.
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Academic Article
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Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts.
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Academic Article
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Molecular remodeling of potassium channels in fibroblasts from centenarians: a marker of longevity?
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Academic Article
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Effects of conditional depletion of topoisomerase II on cell cycle progression in mammalian cells.
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Academic Article
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Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing.
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Academic Article
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A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents.
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Academic Article
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Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs.
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Academic Article
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p21Waf1/Cip1/Sdi1-induced growth arrest is associated with depletion of mitosis-control proteins and leads to abnormal mitosis and endoreduplication in recovering cells.
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Academic Article
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A combination of genetic suppressor elements produces resistance to drugs inhibiting DNA replication.
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Academic Article
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Altered activity of MDR-reversing agents on KB3-1 cells transfected with Gly(185)-->Val human P-glycoprotein.
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Academic Article
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Pleiotropic resistance to DNA-interactive drugs is associated with increased expression of genes involved in DNA replication, repair, and stress response.
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Academic Article
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P-glycoprotein-mediated colchicine resistance in different cell lines correlates with the effects of colchicine on P-glycoprotein conformation.
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Academic Article
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Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene.
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Academic Article
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Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent.
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Academic Article
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If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells.
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Academic Article
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Retinoid-induced growth arrest of breast carcinoma cells involves co-activation of multiple growth-inhibitory genes.
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