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Cell Cycle Proteins
Beta-catenin induces beta-TrCP-mediated PER2 degradation altering circadian clock gene expression in intestinal mucosa of ApcMin/+ mice.
Circadian clock coordinates cancer cell cycle progression, thymidylate synthase, and 5-fluorouracil therapeutic index.
Down regulation of circadian clock gene Period 2 accelerates breast cancer growth by altering its daily growth rhythm.
Period 2 mutation accelerates ApcMin/+ tumorigenesis.
Circadian time-dependent tumor suppressor function of period genes.
Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control.
Circadian expression of clock genes in human oral mucosa and skin: association with specific cell-cycle phases.
Circadian chemotherapy for gynecological and genitourinary cancers.