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McInnes, Campbell
One or more keywords matched the following items that are connected to McInnes, Campbell
Item TypeName
Academic Article Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
Concept CDC2-CDC28 Kinases
Concept Cyclin-Dependent Kinase 8
Concept p38 Mitogen-Activated Protein Kinases
Concept Cyclin-Dependent Kinases
Concept Protein Kinase Inhibitors
Concept Cyclin-Dependent Kinase Inhibitor p21
Concept CDC2 Protein Kinase
Concept Cyclic AMP-Dependent Protein Kinases
Concept Protein Kinases
Concept Cyclin-Dependent Kinase 2
Concept MAP Kinase Kinase Kinases
Concept Cyclin-Dependent Kinase 4
Concept Cyclin-Dependent Kinase 9
Concept MAP Kinase Signaling System
Concept Extracellular Signal-Regulated MAP Kinases
Concept Mitogen-Activated Protein Kinase 10
Concept Cyclin-Dependent Kinase Inhibitor p27
Academic Article Targeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype.
Academic Article Insights into cyclin groove recognition: complex crystal structures and inhibitor design through ligand exchange.
Academic Article 2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.
Academic Article Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors.
Academic Article Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors.
Academic Article Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes.
Academic Article Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design.
Academic Article Progress in the discovery of polo-like kinase inhibitors.
Academic Article Strategies for the design of potent and selective kinase inhibitors.
Academic Article Protein structures in virtual screening: a case study with CDK2.
Academic Article Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design.
Academic Article Structure-based discovery and optimization of potential cancer therapeutics targeting the cell cycle.
Academic Article Improved lead-finding for kinase targets using high-throughput docking.
Academic Article Catch the kinase conformer.
Academic Article Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance.
Academic Article REPLACE: a strategy for iterative design of cyclin-binding groove inhibitors.
Academic Article Progress in the evaluation of CDK inhibitors as anti-tumor agents.
Academic Article Non-ATP competitive protein kinase inhibitors as anti-tumor therapeutics.
Academic Article Truncation and optimisation of peptide inhibitors of cyclin-dependent kinase 2-cyclin a through structure-guided design.
Academic Article Design, synthesis, and evaluation of 2-methyl- and 2-amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as ring-constrained 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin-dependent kinase inhibitors.
Academic Article Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors.
Academic Article Structural and functional analysis of cyclin D1 reveals p27 and substrate inhibitor binding requirements.
Academic Article Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents.
Academic Article PLK1 as an oncology target: current status and future potential.
Academic Article Optimization of non-ATP competitive CDK/cyclin groove inhibitors through REPLACE-mediated fragment assembly.
Academic Article Fragment based discovery of arginine isosteres through REPLACE: towards non-ATP competitive CDK inhibitors.
Academic Article Current assessment of polo-like kinases as anti-tumor drug targets.
Academic Article Iterative conversion of cyclin binding groove peptides into druglike CDK inhibitors with antitumor activity.
Academic Article Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors.
Academic Article Benzamide capped peptidomimetics as non-ATP competitive inhibitors of CDK2 using the REPLACE strategy.
Academic Article The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1.
Academic Article Design and Synthesis of Type-IV Inhibitors of BRAF Kinase That Block Dimerization and Overcome Paradoxical MEK/ERK Activation.
Academic Article Peptidomimetic design of CDK inhibitors targeting the recruitment site of the cyclin subunit.
Academic Article Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop.
Academic Article Peptidomimetic Polo-Box-Targeted Inhibitors that Engage PLK1 in Tumor Cells and Are Selective against the PLK3 Tumor Suppressor.
Concept Aurora Kinase A
Concept Aurora Kinases
Academic Article PharmaDiscovery 2005. Kinases in drug discovery.
Academic Article Nonpeptidic, Polo-Box Domain-Targeted Inhibitors of PLK1 Block Kinase Activity, Induce Its Degradation and Target-Resistant Cells.
Academic Article Structure-activity and mechanistic studies of non-peptidic inhibitors of the PLK1 polo box domain identified through REPLACE.
Academic Article A Selective and Orally Bioavailable Quinoline-6-Carbonitrile-Based Inhibitor of CDK8/19 Mediator Kinase with Tumor-Enriched Pharmacokinetics.
Academic Article Inhibitors of the PLK1 polo-box domain: drug design strategies and therapeutic opportunities in cancer.
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