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Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
Proto-Oncogene Proteins c-pim-1
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins c-mdm2
Targeting subcellular localization through the polo-box domain: non-ATP competitive inhibitors recapitulate a PLK1 phenotype.
Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors.
Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding.
Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance.
PLK1 as an oncology target: current status and future potential.
Current assessment of polo-like kinases as anti-tumor drug targets.
The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1.
Design and Synthesis of Type-IV Inhibitors of BRAF Kinase That Block Dimerization and Overcome Paradoxical MEK/ERK Activation.
Peptidomimetic Polo-Box-Targeted Inhibitors that Engage PLK1 in Tumor Cells and Are Selective against the PLK3 Tumor Suppressor.
Nonpeptidic, Polo-Box Domain-Targeted Inhibitors of PLK1 Block Kinase Activity, Induce Its Degradation and Target-Resistant Cells.
Structure-activity and mechanistic studies of non-peptidic inhibitors of the PLK1 polo box domain identified through REPLACE.