-
Eckert MA, Iuricich F, Harris KC, Hamlett ED, Vazey EM, Aston-Jones G. Locus coeruleus and dorsal cingulate morphology contributions to slowed processing speed. Neuropsychologia. 2023 01 28; 179:108449.
PMID: 36528219; PMCID: PMC9906468.
Citations: Fields:
Translation:
Humans
-
Lin H, Dixon SG, Hu W, Hamlett ED, Jin J, Ergul A, Wang GY, Lin H, Dixon SG, Hu W, Hamlett ED, Jin J, Ergul A, Wang GY. p38 MAPK Is a Major Regulator of Amyloid Beta-Induced IL-6 Expression in Human Microglia. Mol Neurobiol. 2022 Sep; 59(9):5284-5298.
PMID: 35697992; PMCID: PMC9398979.
Citations:
2 Fields:
Translation:
HumansCells
-
Benitez A, Jensen JH, Thorn K, Dhiman S, Fountain-Zaragoza S, Rieter WJ, Spampinato MV, Hamlett ED, Nietert PJ, Falangola MF, Helpern JA, Benitez A, Jensen JH, Thorn K, Dhiman S, Fountain-Zaragoza S, Rieter WJ, Spampinato MV, Hamlett ED, Nietert PJ, Falangola MF, Helpern JA. Greater Diffusion Restriction in White Matter in Preclinical Alzheimer Disease. Ann Neurol. 2022 06; 91(6):864-877.
PMID: 35285067; PMCID: PMC9106903.
Citations:
-
Li P, Wu Y, Hamlett ED, Goodwin AJ, Halushka PV, Carroll SL, Liu M, Fan H, Li P, Wu Y, Hamlett ED, Goodwin AJ, Halushka PV, Carroll SL, Liu M, Fan H. Suppression of Fli-1 protects against pericyte loss and cognitive deficits in Alzheimer's disease. Mol Ther. 2022 04 06; 30(4):1451-1464.
PMID: 35038582; PMCID: PMC9077320.
Citations:
-
Luo Z, Fitting S, Robinson C, Benitez A, Li M, Wu Y, Fu X, Amato D, Ning W, Funderburg N, Wang X, Zhou Z, Yu X, Wagner A, Cong X, Xu W, Maas K, Wolf BJ, Huang L, Yu J, Scott A, Mcrae-Clark A, Hamlett ED, Jiang W, Luo Z, Fitting S, Robinson C, Benitez A, Li M, Wu Y, Fu X, Amato D, Ning W, Funderburg N, Wang X, Zhou Z, Yu X, Wagner A, Cong X, Xu W, Maas K, Wolf BJ, Huang L, Yu J, Scott A, Mcrae-Clark A, Hamlett ED, Jiang W. Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes, macrophage infiltration, and increases ?-amyloid protein production in the brain. EBioMedicine. 2021 Dec; 74:103701.
PMID: 34826801; PMCID: PMC8626580.
Citations:
-
Ledreux A, Thomas S, Hamlett ED, Trautman C, Gilmore A, Rickman Hager E, Paredes DA, Margittai M, Fortea J, Granholm AC, Ledreux A, Thomas S, Hamlett ED, Trautman C, Gilmore A, Rickman Hager E, Paredes DA, Margittai M, Fortea J, Granholm AC. Small Neuron-Derived Extracellular Vesicles from Individuals with Down Syndrome Propagate Tau Pathology in the Wildtype Mouse Brain. J Clin Med. 2021 Aug 31; 10(17).
PMID: 34501378; PMCID: PMC8432237.
Citations:
-
Zhenwu L, Fitting S, Robinson C, Benitez A, Min L, Wu Y, Xiaoyu F, Amato D, Ning W, Funderburg N, Wagner A, Mcrae-Clark A, Hamlett E, Jiang W. Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes and increases β-amyloid protein production in the brain.In peer review stage. 2021.
-
Dierssen M, Herault Y, Helguera P, Martínez de Lagran M, Vazquez A, Christian B, Carmona-Iragui M, Wiseman F, Mobley W, Fisher EMC, Brault V, Esbensen A, Jacola LM, Potier MC, Hamlett ED, Abbeduto L, Del Hoyo Soriano L, Busciglio J, Iulita MF, Crispino J, Malinge S, Barone E, Perluigi M, Costanzo F, Delabar JM, Bartesaghi R, Dekker AD, De Deyn P, Fortea Ormaechea J, Shaw PA, Haydar TF, Sherman SL, Strydom A, Bhattacharyya A, Dierssen M, Herault Y, Helguera P, Mart?nez de Lagran M, Vazquez A, Christian B, Carmona-Iragui M, Wiseman F, Mobley W, Fisher EMC, Brault V, Esbensen A, Jacola LM, Potier MC, Hamlett ED, Abbeduto L, Del Hoyo Soriano L, Busciglio J, Iulita MF, Crispino J, Malinge S, Barone E, Perluigi M, Costanzo F, Delabar JM, Bartesaghi R, Dekker AD, De Deyn P, Fortea Ormaechea J, Shaw PA, Haydar TF, Sherman SL, Strydom A, Bhattacharyya A. Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society. Mol Syndromol. 2021 Jul; 12(4):202-218.
PMID: 34421499; PMCID: PMC8339505.
Citations:
-
Dierssen M, Herault Y, Helguera P, Martínez de Lagran M,Vazquez A, Christian B, Carmona Iragui M, Wiseman F, Mobley W, Fisher, Brault V, Esbensen A, Jacola LM, Potier M, Hamlett ED, Abbeduto L, del Hoyo Soriano L, Busciglio J, Iulita F, Crispino J, Malinge S, Barone E, Perluigi M, Costanzo F, Delabar J, Bartesaghi R, Dekker A, De Deyn P, Fortea J, Shaw P, Haydar T, Sherman S, Strydom A, Bhattacharyya A. Building future therapies for DS: The Third International Conference of the T21 Research Society.Mol Syndromology. 2021. Accepted in production. 2021.
-
Iulutita MF, Granholm A, Carmona-Iragui M, Hamlett ED, Fortea J, Ledreux A. Fluid Biomarkers for Alzheimer’s disease in Down syndrome: Current Status and Novel Trends; Book chapter in The Neurobiology of Aging and Alzheimer Disease in Down Syndrome 1st Edition, 2021. ISBN: 9780128188453. 2021.
-
Lemoine L, Ledreux A, Mufson EJ, Perez SE, Simic G, Doran E, Lott I, Carroll S, Bharani K, Thomas S, Gilmore A, Hamlett ED, Nordberg A, Granholm AC. Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue. 2020; 1(15):68.
-
Lemoine L, Ledreux A, Mufson EJ, Perez SE, Simic G, Doran E, Lott I, Carroll S, Bharani K, Thomas S, Gilmore A, Hamlett ED, Nordberg A, Granholm AC, Lemoine L, Ledreux A, Mufson EJ, Perez SE, Simic G, Doran E, Lott I, Carroll S, Bharani K, Thomas S, Gilmore A, Hamlett ED, Nordberg A, Granholm AC. Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue. Mol Neurodegener. 2020 11 23; 15(1):68.
PMID: 33222700; PMCID: PMC7682014.
Citations:
-
Hamlett ED, Hjorth E, Ledreux A, Gilmore A, Schultzberg M, Granholm AC, Hamlett ED, Hjorth E, Ledreux A, Gilmore A, Schultzberg M, Granholm AC. RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome. Glia. 2020 07; 68(7):1347-1360.
PMID: 31944407; PMCID: PMC7205572.
Citations:
-
Hamlett ED, Ledreux A, Gilmore A, Vazey EM, Aston-Jones G, Boger HA, Paredes D, Granholm AE, Hamlett ED, Ledreux A, Gilmore A, Vazey EM, Aston-Jones G, Boger HA, Paredes D, Granholm AE. Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome. Neurobiol Dis. 2020 02; 134:104616.
PMID: 31678403; PMCID: PMC7722242.
Citations:
-
Hamlett ED, LaRosa A, Mufson EJ, Fortea J, Ledreux A, Granholm AC, Hamlett ED, LaRosa A, Mufson EJ, Fortea J, Ledreux A, Granholm AC. Exosome release and cargo in Down syndrome. Dev Neurobiol. 2019 07; 79(7):639-655.
PMID: 31347291; PMCID: PMC7388580.
Citations:
-
Watson LS, Hamlett ED, Stone TD, Sims-Robinson C, Watson LS, Hamlett ED, Stone TD, Sims-Robinson C. Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer's disease. Mol Neurodegener. 2019 06 10; 14(1):22.
PMID: 31182115; PMCID: PMC6558712.
Citations:
-
Hamlett ED, Ledreux A, Potter H, Chial HJ, Patterson D, Espinosa JM, Bettcher BM, Granholm AC, Hamlett ED, Ledreux A, Potter H, Chial HJ, Patterson D, Espinosa JM, Bettcher BM, Granholm AC. Exosomal biomarkers in Down syndrome and Alzheimer's disease. Free Radic Biol Med. 2018 01; 114:110-121.
PMID: 28882786; PMCID: PMC6135098.
Citations:
-
Hamlett ED, Goetzl EJ, Ledreux A, Vasilevko V, Boger HA, LaRosa A, Clark D, Carroll SL, Carmona-Iragui M, Fortea J, Mufson EJ, Sabbagh M, Mohammed AH, Hartley D, Doran E, Lott IT, Granholm AC, Hamlett ED, Goetzl EJ, Ledreux A, Vasilevko V, Boger HA, LaRosa A, Clark D, Carroll SL, Carmona-Iragui M, Fortea J, Mufson EJ, Sabbagh M, Mohammed AH, Hartley D, Doran E, Lott IT, Granholm AC. Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome. Alzheimers Dement. 2017 May; 13(5):541-549.
PMID: 27755974; PMCID: PMC5812672.
Citations:
-
Hamlett ED, Boger HA, Ledreux A, Kelley CM, Mufson EJ, Falangola MF, Guilfoyle DN, Nixon RA, Patterson D, Duval N, Granholm AC, Hamlett ED, Boger HA, Ledreux A, Kelley CM, Mufson EJ, Falangola MF, Guilfoyle DN, Nixon RA, Patterson D, Duval N, Granholm AC. Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome. Curr Alzheimer Res. 2016; 13(1):35-52.
PMID: 26391050; PMCID: PMC5034871.
Citations:
-
Hiller S, DeKroon R, Hamlett ED, Xu L, Osorio C, Robinette J, Winnik W, Simington S, Maeda N, Alzate O, Yi X, Hiller S, DeKroon R, Hamlett ED, Xu L, Osorio C, Robinette J, Winnik W, Simington S, Maeda N, Alzate O, Yi X. Alpha-lipoic acid supplementation protects enzymes from damage by nitrosative and oxidative stress. Biochim Biophys Acta. 2016 Jan; 1860(1 Pt A):36-45.
PMID: 26344063; PMCID: PMC5293714.
Citations:
-
Fortress AM, Hamlett ED, Vazey EM, Aston-Jones G, Cass WA, Boger HA, Granholm AC, Fortress AM, Hamlett ED, Vazey EM, Aston-Jones G, Cass WA, Boger HA, Granholm AC. Designer receptors enhance memory in a mouse model of Down syndrome. J Neurosci. 2015 Jan 28; 35(4):1343-53.
PMID: 25632113; PMCID: PMC4308587.
Citations:
-
Nie X, Hamlett ED, Granholm AC, Hui ES, Helpern JA, Jensen JH, Boger HA, Collins HR, Falangola MF, Nie X, Hamlett ED, Granholm AC, Hui ES, Helpern JA, Jensen JH, Boger HA, Collins HR, Falangola MF. Evidence of altered age-related brain cytoarchitecture in mouse models of down syndrome: a diffusional kurtosis imaging study. Magn Reson Imaging. 2015 May; 33(4):437-47.
PMID: 25527393; PMCID: PMC4747671.
Citations:
-
Rubel CE, Schisler JC, Hamlett ED, DeKroon RM, Gautel M, Alzate O, Patterson C, Rubel CE, Schisler JC, Hamlett ED, DeKroon RM, Gautel M, Alzate O, Patterson C. Diggin' on u(biquitin): a novel method for the identification of physiological E3 ubiquitin ligase substrates. Cell Biochem Biophys. 2013 Sep; 67(1):127-38.
PMID: 23695782; PMCID: PMC3758785.
Citations:
-
Londono C, DeKroon RM, Mocanu M, Booe J, Winnik WM, Swank A, Osorio C, Hamlett ED, Alzate O, Londono C, DeKroon RM, Mocanu M, Booe J, Winnik WM, Swank A, Osorio C, Hamlett ED, Alzate O. Proteomic analysis of mice expressing human ApoE demonstrates no differences in global protein solubility between APOE 3 and APOE 4 young mice. Electrophoresis. 2012 Dec; 33(24):3745-55.
PMID: 23161654.
Citations:
-
Winnik WM, Dekroon RM, Jeong JS, Mocanu M, Robinette JB, Osorio C, Dicheva NN, Hamlett E, Alzate O, Winnik WM, Dekroon RM, Jeong JS, Mocanu M, Robinette JB, Osorio C, Dicheva NN, Hamlett E, Alzate O. Analysis of proteins using DIGE and MALDI mass spectrometry. Methods Mol Biol. 2012; 854:47-66.
PMID: 22311753.
Citations:
-
DeKroon RM, Robinette JB, Osorio C, Jeong JS, Hamlett E, Mocanu M, Alzate O, DeKroon RM, Robinette JB, Osorio C, Jeong JS, Hamlett E, Mocanu M, Alzate O. Analysis of protein posttranslational modifications using DIGE-based proteomics. Methods Mol Biol. 2012; 854:129-43.
PMID: 22311757.
Citations:
-
Duan J, Gherghe C, Liu D, Hamlett E, Srikantha L, Rodgers L, Regan JN, Rojas M, Willis M, Leask A, Majesky M, Deb A, Duan J, Gherghe C, Liu D, Hamlett E, Srikantha L, Rodgers L, Regan JN, Rojas M, Willis M, Leask A, Majesky M, Deb A. Wnt1/?catenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. EMBO J. 2012 Jan 18; 31(2):429-42.
PMID: 22085926; PMCID: PMC3261567.
Citations:
-
Khatun J, Hamlett E, Giddings MC, Khatun J, Hamlett E, Giddings MC. Incorporating sequence information into the scoring function: a hidden Markov model for improved peptide identification. Bioinformatics. 2008 Mar 01; 24(5):674-81.
PMID: 18187442; PMCID: PMC2699941.
Citations:
-
Yang D, Ramkissoon K, Hamlett E, Giddings MC, Yang D, Ramkissoon K, Hamlett E, Giddings MC. High-accuracy peptide mass fingerprinting using peak intensity data with machine learning. J Proteome Res. 2008 Jan; 7(1):62-9.
PMID: 17914788.
Citations: