Ayad A. Jaffa

Title
InstitutionMedical University of South Carolina
DepartmentEndocrinology
AddressP.O. Box MSC 776
STB 504
Thurmond Gazes - 30 Courtenay Drive
Phone843-876-5245
Fax843-876-5133
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Karam M, Fahs D, Maatouk B, Safi B, Jaffa AA, Mhanna R, Karam M, Fahs D, Maatouk B, Safi B, Jaffa AA, Mhanna R. Polymeric nanoparticles in the diagnosis and treatment of myocardial infarction: Challenges and future prospects. Mater Today Bio. 2022 Mar; 14:100249. PMID: 35434594; PMCID: PMC9006854.
      Citations: 1     
    2. Jaffa MA, Gebregziabher M, Jaffa AA, Jaffa MA, Gebregziabher M, Jaffa AA. Shared parameter and copula models for analysis of semicontinuous longitudinal data with nonrandom dropout and informative censoring. Stat Methods Med Res. 2022 03; 31(3):451-474. PMID: 34806502; PMCID: PMC8891057.
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    3. Jaffa AA, Jaffa MA, Moussa M, Ahmed IA, Karam M, Aldeen KS, Al Sayegh R, El-Achkar GA, Nasrallah L, Yehya Y, Habib A, Ziyadeh FN, Eid AH, Kobeissy FH, Jaffa AA, Jaffa AA, Jaffa MA, Moussa M, Ahmed IA, Karam M, Aldeen KS, Al Sayegh R, El-Achkar GA, Nasrallah L, Yehya Y, Habib A, Ziyadeh FN, Eid AH, Kobeissy FH, Jaffa AA. Modulation of Neuro-Inflammatory Signals in Microglia by Plasma Prekallikrein and Neuronal Cell Debris. Front Pharmacol. 2021; 12:743059. PMID: 34867349; PMCID: PMC8636058.
      Citations:    
    4. Maatouk B, Jaffa MA, Karam M, Fahs D, Nour-Eldine W, Hasan A, Jaffa AA, Mhanna R, Maatouk B, Jaffa MA, Karam M, Fahs D, Nour-Eldine W, Hasan A, Jaffa AA, Mhanna R. Sulfated alginate/polycaprolactone double-emulsion nanoparticles for enhanced delivery of heparin-binding growth factors in wound healing applications. Colloids Surf B Biointerfaces. 2021 Dec; 208:112105. PMID: 34536674.
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    5. Ahmed IA, Jaffa MA, Moussa M, Hatem D, El-Achkar GA, Al Sayegh R, Karam M, Hamade E, Habib A, Jaffa AA, Ahmed IA, Jaffa MA, Moussa M, Hatem D, El-Achkar GA, Al Sayegh R, Karam M, Hamade E, Habib A, Jaffa AA. Plasma Kallikrein as a Modulator of Liver Injury/Remodeling. Front Pharmacol. 2021; 12:715111. PMID: 34566641; PMCID: PMC8458624.
      Citations:    
    6. Hariri MA, Jaffa MA, Saoud R, Zhao J, Zhu R, Jaffa AA, El-Achkar GA, Moussa M, Kobeissy F, Hassan A, Ziyadeh FN, Mechref Y, Jaffa AA, Hariri MA, Jaffa MA, Saoud R, Zhao J, Zhu R, Jaffa AA, El-Achkar GA, Moussa M, Kobeissy F, Hassan A, Ziyadeh FN, Mechref Y, Jaffa AA. Vascular Cells Proteome Associated with Bradykinin and Leptin Inflammation and Oxidative Stress Signals. Antioxidants (Basel). 2020 Dec 09; 9(12). PMID: 33316969; PMCID: PMC7764689.
      Citations:    
    7. Itani HA, Jaffa MA, Elias J, Sabra M, Zakka P, Ballout J, Bekdash A, Ibrahim R, Al Hariri M, Ghemrawi M, Abi-Saleh B, Khoury M, Alam S, Mahfouz R, Jaffa AA, Azar ST, Refaat MM, Itani HA, Jaffa MA, Elias J, Sabra M, Zakka P, Ballout J, Bekdash A, Ibrahim R, Al Hariri M, Ghemrawi M, Abi-Saleh B, Khoury M, Alam S, Mahfouz R, Jaffa AA, Azar ST, Refaat MM. Genomic and Proteomic Study of the Inflammatory Pathway in Patients With Atrial Fibrillation and Cardiometabolic Syndrome. Front Cardiovasc Med. 2020; 7:613271. PMID: 33344519; PMCID: PMC7738559.
      Citations:    
    8. Jaffa MA, Bebu I, Luttrell D, Braffett BH, Lachin JM, Hunt K, Lopes-Virella M, Luttrell L, Lyons TJ, Jaffa AA, Jaffa MA, Bebu I, Luttrell D, Braffett BH, Lachin JM, Hunt K, Lopes-Virella M, Luttrell L, Lyons TJ, Jaffa AA, DCCT/EDIC Research Group. Longitudinal Plasma Kallikrein Levels and Their Association With the Risk of Cardiovascular Disease Outcomes in Type 1 Diabetes in DCCT/EDIC. Diabetes. 2020 11; 69(11):2440-2445. PMID: 32826295; PMCID: PMC7576572.
      Citations:    
    9. Saoud R, Jaffa MA, Habib A, Zhao J, Al Hariri M, Zhu R, Hasan A, Ziyadeh FN, Kobeissy F, Mechref Y, Jaffa AA, Saoud R, Jaffa MA, Habib A, Zhao J, Al Hariri M, Zhu R, Hasan A, Ziyadeh FN, Kobeissy F, Mechref Y, Jaffa AA. Modulation of proteomic and inflammatory signals by Bradykinin in podocytes. J Adv Res. 2020 Jul; 24:409-422. PMID: 32518694; PMCID: PMC7270529.
      Citations:    
    10. Dagher OK, Jaffa MA, Habib A, Ziyadeh FN, Jaffa AA, Dagher OK, Jaffa MA, Habib A, Ziyadeh FN, Jaffa AA. Heteromerization fingerprints between bradykinin B2 and thromboxane TP receptors in native cells. PLoS One. 2019; 14(5):e0216908. PMID: 31086419; PMCID: PMC6516669.
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    11. El-Achkar GA, Mrad MF, Mouawad CA, Badran B, Jaffa AA, Motterlini R, Hamade E, Habib A, El-Achkar GA, Mrad MF, Mouawad CA, Badran B, Jaffa AA, Motterlini R, Hamade E, Habib A. Heme oxygenase-1-Dependent anti-inflammatory effects of atorvastatin in zymosan-injected subcutaneous air pouch in mice. PLoS One. 2019; 14(5):e0216405. PMID: 31071151; PMCID: PMC6508873.
      Citations:    
    12. Jaffa MA, Gebregziabher M, Garrett SM, Luttrell DK, Lipson KE, Luttrell LM, Jaffa AA, Jaffa MA, Gebregziabher M, Garrett SM, Luttrell DK, Lipson KE, Luttrell LM, Jaffa AA. Analysis of longitudinal semicontinuous data using marginalized two-part model. J Transl Med. 2018 11 06; 16(1):301. PMID: 30400798; PMCID: PMC6219033.
      Citations:    
    13. Jaffa MA, Jaffa AA, Jaffa MA, Jaffa AA. A Likelihood Based Approach for Joint Modeling of Longitudinal Trajectories and Informative Censoring Process. Commun Stat Theory Methods. 2019; 48(12):2982-3004. PMID: 31571721; PMCID: PMC6768558.
      Citations:    
    14. Nokkari A, Abou-El-Hassan H, Mechref Y, Mondello S, Kindy MS, Jaffa AA, Kobeissy F, Nokkari A, Abou-El-Hassan H, Mechref Y, Mondello S, Kindy MS, Jaffa AA, Kobeissy F. Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms. Prog Neurobiol. 2018 Jun - Aug; 165-167:26-50. PMID: 29355711; PMCID: PMC6026079.
      Citations:    
    15. Hunt KJ, Jaffa MA, Garrett SM, Luttrell DK, Lipson KE, Lopes-Virella MF, Luttrell LM, Jaffa AA, Hunt KJ, Jaffa MA, Garrett SM, Luttrell DK, Lipson KE, Lopes-Virella MF, Luttrell LM, Jaffa AA, VADT Investigators. Plasma Connective Tissue Growth Factor (CTGF/CCN2) Levels Predict Myocardial Infarction in the Veterans Affairs Diabetes Trial (VADT) Cohort. Diabetes Care. 2018 04; 41(4):840-846. PMID: 29382658; PMCID: PMC5860844.
      Citations:    
    16. Al Hariri M, Elmedawar M, Zhu R, Jaffa MA, Zhao J, Mirzaei P, Ahmed A, Kobeissy F, Ziyadeh FN, Mechref Y, Jaffa AA, Al Hariri M, Elmedawar M, Zhu R, Jaffa MA, Zhao J, Mirzaei P, Ahmed A, Kobeissy F, Ziyadeh FN, Mechref Y, Jaffa AA. Proteome profiling in the aorta and kidney of type 1 diabetic rats. PLoS One. 2017; 12(11):e0187752. PMID: 29121074; PMCID: PMC5679573.
      Citations:    
    17. Jaffa MA, Gebregziabher M, Luttrell DK, Luttrell LM, Jaffa AA, Jaffa MA, Gebregziabher M, Luttrell DK, Luttrell LM, Jaffa AA. Multivariate Generalized Linear Mixed Models With Random Intercepts To Analyze Cardiovascular Risk Markers in Type-1 Diabetic Patients. J Appl Stat. 2016; 43(8):1447-1464. PMID: 27829695; PMCID: PMC5098498.
      Citations:    
    18. Jaffa MA, Luttrell D, Schmaier AH, Klein RL, Lopes-Virella M, Luttrell LM, Jaffa AA, Jaffa MA, Luttrell D, Schmaier AH, Klein RL, Lopes-Virella M, Luttrell LM, Jaffa AA, DCCT/EDIC Research Group. Plasma Prekallikrein Is Associated With Carotid Intima-Media Thickness in Type 1 Diabetes. Diabetes. 2016 Feb; 65(2):498-502. PMID: 26603531; PMCID: PMC4747454.
      Citations:    
    19. Abou Msallem J, Chalhoub H, Al-Hariri M, Saad L, Jaffa MA, Ziyadeh FN, Jaffa AA, Abou Msallem J, Chalhoub H, Al-Hariri M, Saad L, Jaffa MA, Ziyadeh FN, Jaffa AA. Mechanisms of bradykinin-induced expression of connective tissue growth factor and nephrin in podocytes. Am J Physiol Renal Physiol. 2015 Dec 01; 309(11):F980-90. PMID: 26447218; PMCID: PMC4669358.
      Citations:    
    20. Nokkari A, Mouhieddine TH, Itani MM, Abou-Kheir W, Daoud G, Zhu R, Mechref Y, Soueid J, Al Hariri M, Mondello S, Jaffa AA, Kobeissy F, Nokkari A, Mouhieddine TH, Itani MM, Abou-Kheir W, Daoud G, Zhu R, Mechref Y, Soueid J, Al Hariri M, Mondello S, Jaffa AA, Kobeissy F. Correction: Characterization of the Kallikrein-Kinin System Post Chemical Neuronal Injury: An In Vitro Biochemical and Neuroproteomics Assessment. PLoS One. 2015; 10(8):e0136345. PMID: 26288275; PMCID: PMC4543601.
      Citations:    
    21. Jaffa MA, Gebregziabher M, Jaffa AA, Jaffa MA, Gebregziabher M, Jaffa AA. Analysis of multivariate longitudinal kidney function outcomes using generalized linear mixed models. J Transl Med. 2015 Jun 14; 13:192. PMID: 26072119; PMCID: PMC4467678.
      Citations:    
    22. Nokkari A, Mouhieddine TH, Itani MM, Abou-Kheir W, Daoud G, Zhu R, Mechref Y, Meshref Y, Soueid J, Al Hariri M, Mondello S, Jaffa AA, Kobeissy F, Nokkari A, Mouhieddine TH, Itani MM, Abou-Kheir W, Daoud G, Zhu R, Mechref Y, Meshref Y, Soueid J, Al Hariri M, Mondello S, Jaffa AA, Kobeissy F. Characterization of the Kallikrein-Kinin System Post Chemical Neuronal Injury: An In Vitro Biochemical and Neuroproteomics Assessment. PLoS One. 2015; 10(6):e0128601. PMID: 26047500; PMCID: PMC4457722.
      Citations:    
    23. Wilson PC, Fitzgibbon WR, Garrett SM, Jaffa AA, Luttrell LM, Brands MW, El-Shewy HM, Wilson PC, Fitzgibbon WR, Garrett SM, Jaffa AA, Luttrell LM, Brands MW, El-Shewy HM. Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel. Mol Endocrinol. 2015 Jun; 29(6):896-908. PMID: 25871850; PMCID: PMC4447644.
      Citations:    
    24. Jaffa MA, Jaffa AA, Jaffa MA, Jaffa AA. Joint Modeling of Covariates and Censoring Process Assuming Non-Constant Dropout Hazard. Stat Methods Appt. 2016 Jun; 25(2):251-267. PMID: 27605892; PMCID: PMC5010875.
      Citations:    
    25. Keum JS, Jaffa MA, Luttrell LM, Jaffa AA, Keum JS, Jaffa MA, Luttrell LM, Jaffa AA. Novel mechanism of plasma prekallikrein (PK) activation by vascular smooth muscle cells: evidence of the presence of PK activator. J Biol Regul Homeost Agents. 2014 Oct-Dec; 28(4):587-603. PMID: 25620170; PMCID: PMC4337887.
      Citations:    
    26. Hasan A, Nurunnabi M, Morshed M, Paul A, Polini A, Kuila T, Al Hariri M, Lee YK, Jaffa AA, Hasan A, Nurunnabi M, Morshed M, Paul A, Polini A, Kuila T, Al Hariri M, Lee YK, Jaffa AA. Recent advances in application of biosensors in tissue engineering. Biomed Res Int. 2014; 2014:307519. PMID: 25165697; PMCID: PMC4140114.
      Citations:    
    27. Orr RK, Hoehn JL, Col NF, Jaffa MA, Gebregziabher M, Jaffa AA. A Joint Modeling Approach for Right Censored High Dimensional Multivariate Longitudinal Data. J Biom Biostat. 2014 Aug; 5(4). PMID: 25688330; PMCID: PMC4327878.
      Citations:    
    28. Ienaga K, Sohn M, Naiki M, Jaffa AA, Ienaga K, Sohn M, Naiki M, Jaffa AA. Creatinine metabolite, HMH (5-hydroxy-1-methylhydantoin; NZ-419), modulates bradykinin-induced changes in vascular smooth muscle cells. J Recept Signal Transduct Res. 2014 Jun; 34(3):195-200. PMID: 24641698.
      Citations:    
    29. Eid S, Maalouf R, Jaffa AA, Nassif J, Hamdy A, Rashid A, Ziyadeh FN, Eid AA, Eid S, Maalouf R, Jaffa AA, Nassif J, Hamdy A, Rashid A, Ziyadeh FN, Eid AA. 20-HETE and EETs in diabetic nephropathy: a novel mechanistic pathway. PLoS One. 2013; 8(8):e70029. PMID: 23936373; PMCID: PMC3732284.
      Citations:    
    30. Eid S, Abou-Kheir W, Sabra R, Daoud G, Jaffa A, Ziyadeh FN, Roman L, Eid AA, Eid S, Abou-Kheir W, Sabra R, Daoud G, Jaffa A, Ziyadeh FN, Roman L, Eid AA. Involvement of renal cytochromes P450 and arachidonic acid metabolites in diabetic nephropathy. J Biol Regul Homeost Agents. 2013 Jul-Sep; 27(3):693-703. PMID: 24152838.
      Citations:    
    31. Najjar SM, Ledford KJ, Abdallah SL, Paus A, Russo L, Kaw MK, Ramakrishnan SK, Muturi HT, Raphael CK, Lester SG, Heinrich G, Pierre SV, Benndorf R, Kleff V, Jaffa AA, Lévy E, Vazquez G, Goldberg IJ, Beauchemin N, Scalia R, Ergün S, Najjar SM, Ledford KJ, Abdallah SL, Paus A, Russo L, Kaw MK, Ramakrishnan SK, Muturi HT, Raphael CK, Lester SG, Heinrich G, Pierre SV, Benndorf R, Kleff V, Jaffa AA, L?vy E, Vazquez G, Goldberg IJ, Beauchemin N, Scalia R, Erg?n S. Ceacam1 deletion causes vascular alterations in large vessels. Am J Physiol Endocrinol Metab. 2013 Aug 15; 305(4):E519-29. PMID: 23800882; PMCID: PMC3891225.
      Citations:    
    32. Wilson PC, Lee MH, Appleton KM, El-Shewy HM, Morinelli TA, Peterson YK, Luttrell LM, Jaffa AA, Wilson PC, Lee MH, Appleton KM, El-Shewy HM, Morinelli TA, Peterson YK, Luttrell LM, Jaffa AA. The arrestin-selective angiotensin AT1 receptor agonist [Sar1,Ile4,Ile8]-AngII negatively regulates bradykinin B2 receptor signaling via AT1-B2 receptor heterodimers. J Biol Chem. 2013 Jun 28; 288(26):18872-84. PMID: 23661707; PMCID: PMC3696663.
      Citations:    
    33. Orr RK, Hoehn JL, Col NF, Jaffa MA, Kobeissy F, Al Hariri M, Chalhoub H, Eid A, Ziyadeh FN, Jaffa AA. Global renal gene expression profiling analysis in B2-kinin receptor null mice: impact of diabetes. PLoS One. 2012; 7(9):e44714. PMID: 23028588; PMCID: PMC3445541.
      Citations:    
    34. El-Shewy HM, Sohn M, Wilson P, Lee MH, Hammad SM, Luttrell LM, Jaffa AA, El-Shewy HM, Sohn M, Wilson P, Lee MH, Hammad SM, Luttrell LM, Jaffa AA. Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells. Mol Endocrinol. 2012 May; 26(5):833-45. PMID: 22422617; PMCID: PMC3355554.
      Citations:    
    35. Jaffa MA, Jaffa AA, Lipsitz SR, Jaffa MA, Jaffa AA, Lipsitz SR. Slope Estimation of Covariates that Influence Renal Outcome following Renal Transplant Adjusting for Informative Right Censoring. J Appl Stat. 2012; 39(3):631-642. PMID: 25729124; PMCID: PMC4343305.
      Citations:    
    36. El-Shewy HM, Abdel-Samie SA, Al Qalam AM, Lee MH, Kitatani K, Anelli V, Jaffa AA, Obeid LM, Luttrell LM, El-Shewy HM, Abdel-Samie SA, Al Qalam AM, Lee MH, Kitatani K, Anelli V, Jaffa AA, Obeid LM, Luttrell LM. Phospholipase C and protein kinase C-? 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation. Mol Endocrinol. 2011 Dec; 25(12):2144-56. PMID: 22016563; PMCID: PMC3231827.
      Citations:    
    37. Abdallah RT, Keum JS, El-Shewy HM, Lee MH, Wang B, Gooz M, Luttrell DK, Luttrell LM, Jaffa AA, Abdallah RT, Keum JS, El-Shewy HM, Lee MH, Wang B, Gooz M, Luttrell DK, Luttrell LM, Jaffa AA. Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors. J Biol Chem. 2010 Nov 05; 285(45):35206-15. PMID: 20826789; PMCID: PMC2966134.
      Citations:    
    38. Orr RK, Hoehn JL, Col NF, Wang B, Carter RE, Jaffa MA, Nakerakanti S, Lackland D, Lopes-Virella M, Trojanowska M, Luttrell LM, Jaffa AA, DCCT/EDIC Study Group. Genetic variant in the promoter of connective tissue growth factor gene confers susceptibility to nephropathy in type 1 diabetes. J Med Genet. 2010 Jun; 47(6):391-7. PMID: 20522428; PMCID: PMC3828650.
      Citations:    
    39. Webb JG, Tan Y, Jaffa MA, Jaffa AA, Webb JG, Tan Y, Jaffa MA, Jaffa AA. Evidence for prostacyclin and cAMP upregulation by bradykinin and insulin-like growth factor 1 in vascular smooth muscle cells. J Recept Signal Transduct Res. 2010 Apr; 30(2):61-71. PMID: 20082561; PMCID: PMC4327880.
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    40. Jaffa AA, Usinger WR, McHenry MB, Jaffa MA, Lipstiz SR, Lackland D, Lopes-Virella M, Luttrell LM, Wilson PW, Jaffa AA, Usinger WR, McHenry MB, Jaffa MA, Lipstiz SR, Lackland D, Lopes-Virella M, Luttrell LM, Wilson PW, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications St. Connective tissue growth factor and susceptibility to renal and vascular disease risk in type 1 diabetes. J Clin Endocrinol Metab. 2008 May; 93(5):1893-900. PMID: 18319310; PMCID: PMC2386274.
      Citations:    
    41. El-Shewy HM, Lee MH, Obeid LM, Jaffa AA, Luttrell LM, El-Shewy HM, Lee MH, Obeid LM, Jaffa AA, Luttrell LM. The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells. J Biol Chem. 2007 Sep 07; 282(36):26150-7. PMID: 17620336.
      Citations:    
    42. Tan Y, Keum JS, Wang B, McHenry MB, Lipsitz SR, Jaffa AA, Tan Y, Keum JS, Wang B, McHenry MB, Lipsitz SR, Jaffa AA. Targeted deletion of B2-kinin receptors protects against the development of diabetic nephropathy. Am J Physiol Renal Physiol. 2007 Oct; 293(4):F1026-35. PMID: 17596525.
      Citations:    
    43. El-Shewy HM, Johnson KR, Lee MH, Jaffa AA, Obeid LM, Luttrell LM, El-Shewy HM, Johnson KR, Lee MH, Jaffa AA, Obeid LM, Luttrell LM. Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors. J Biol Chem. 2006 Oct 20; 281(42):31399-407. PMID: 16926156.
      Citations:    
    44. Game BA, He L, Jarido V, Nareika A, Jaffa AA, Lopes-Virella MF, Huang Y, Game BA, He L, Jarido V, Nareika A, Jaffa AA, Lopes-Virella MF, Huang Y. Pioglitazone inhibits connective tissue growth factor expression in advanced atherosclerotic plaques in low-density lipoprotein receptor-deficient mice. Atherosclerosis. 2007 May; 192(1):85-91. PMID: 16901490.
      Citations:    
    45. Shariat-Madar Z, Mahdi F, Warnock M, Homeister JW, Srikanth S, Krijanovski Y, Murphey LJ, Jaffa AA, Schmaier AH, Shariat-Madar Z, Mahdi F, Warnock M, Homeister JW, Srikanth S, Krijanovski Y, Murphey LJ, Jaffa AA, Schmaier AH. Bradykinin B2 receptor knockout mice are protected from thrombosis by increased nitric oxide and prostacyclin. Blood. 2006 Jul 01; 108(1):192-9. PMID: 16514058; PMCID: PMC1895832.
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    46. Bergmann S, Zheng D, Barredo J, Abboud MR, Jaffa AA, Bergmann S, Zheng D, Barredo J, Abboud MR, Jaffa AA. Renal kallikrein: a risk marker for nephropathy in children with sickle cell disease. J Pediatr Hematol Oncol. 2006 Mar; 28(3):147-53. PMID: 16679937.
      Citations:    
    47. Sohn M, Tan Y, Wang B, Klein RL, Trojanowska M, Jaffa AA, Sohn M, Tan Y, Wang B, Klein RL, Trojanowska M, Jaffa AA. Mechanisms of low-density lipoprotein-induced expression of connective tissue growth factor in human aortic endothelial cells. Am J Physiol Heart Circ Physiol. 2006 Apr; 290(4):H1624-34. PMID: 16272194.
      Citations:    
    48. Sohn M, Tan Y, Klein RL, Jaffa AA, Sohn M, Tan Y, Klein RL, Jaffa AA. Evidence for low-density lipoprotein-induced expression of connective tissue growth factor in mesangial cells. Kidney Int. 2005 Apr; 67(4):1286-96. PMID: 15780081.
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    49. Tan Y, Wang B, Keum JS, Jaffa AA, Tan Y, Wang B, Keum JS, Jaffa AA. Mechanisms through which bradykinin promotes glomerular injury in diabetes. Am J Physiol Renal Physiol. 2005 Mar; 288(3):F483-92. PMID: 15692059.
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    50. Tan Y, Hutchison FN, Jaffa AA, Tan Y, Hutchison FN, Jaffa AA. Mechanisms of angiotensin II-induced expression of B2 kinin receptors. Am J Physiol Heart Circ Physiol. 2004 Mar; 286(3):H926-32. PMID: 14766673.
      Citations: 8     Fields:    Translation:AnimalsCells
    51. Velarde V, de la Cerda PM, Duarte C, Arancibia F, Abbott E, González A, Moreno F, Jaffa AA, Velarde V, de la Cerda PM, Duarte C, Arancibia F, Abbott E, Gonz?lez A, Moreno F, Jaffa AA. Role of reactive oxygen species in bradykinin-induced proliferation of vascular smooth muscle cells. Biol Res. 2004; 37(3):419-30. PMID: 15515967.
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    52. Jaffa AA, Durazo-Arvizu R, Zheng D, Lackland DT, Srikanth S, Garvey WT, Schmaier AH, Jaffa AA, Durazo-Arvizu R, Zheng D, Lackland DT, Srikanth S, Garvey WT, Schmaier AH, DCCT/EDIC Study Group. Plasma prekallikrein: a risk marker for hypertension and nephropathy in type 1 diabetes. Diabetes. 2003 May; 52(5):1215-21. PMID: 12716755.
      Citations: 28     Fields:    Translation:Humans
    53. Christopher J, Jaffa AA, Christopher J, Jaffa AA. Diabetes modulates the expression of glomerular kinin receptors. Int Immunopharmacol. 2002 Dec; 2(13-14):1771-9. PMID: 12489791.
      Citations: 5     Fields:    Translation:AnimalsCells
    54. Morinelli TA, Meier GP, Webb JG, Jaffa AA, Privitera PJ, Margolius HS, Morinelli TA, Meier GP, Webb JG, Jaffa AA, Privitera PJ, Margolius HS. Utilization of a radioimmunoassay to detect the generation of Arg-Pro-Pro-Gly-Phe, a stable endproduct of bradykinin metabolism (from cultured rat aortic smooth muscle cells exposed to bradykinin). Int Immunopharmacol. 2002 Dec; 2(13-14):1995-2003. PMID: 12489813.
      Citations:    Fields:    Translation:HumansAnimalsCells
    55. Wei CC, Ferrario CM, Brosnihan KB, Farrell DM, Bradley WE, Jaffa AA, Dell'Italia LJ, Wei CC, Ferrario CM, Brosnihan KB, Farrell DM, Bradley WE, Jaffa AA, Dell'Italia LJ. Angiotensin peptides modulate bradykinin levels in the interstitium of the dog heart in vivo. J Pharmacol Exp Ther. 2002 Jan; 300(1):324-9. PMID: 11752132.
      Citations: 7     Fields:    Translation:Animals
    56. Haastrup A, Gadegbeku CA, Zhang D, Mukhin YV, Greene EL, Jaffa AA, Egan BM, Haastrup A, Gadegbeku CA, Zhang D, Mukhin YV, Greene EL, Jaffa AA, Egan BM. Lipids stimulate the production of 6-keto-prostaglandin f(1alpha) in human dorsal hand veins. Hypertension. 2001 Oct; 38(4):858-63. PMID: 11641299.
      Citations: 3     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    57. Christopher J, Velarde V, Jaffa AA, Christopher J, Velarde V, Jaffa AA. Induction of B(1)-kinin receptors in vascular smooth muscle cells: cellular mechanisms of map kinase activation. Hypertension. 2001 Sep; 38(3 Pt 2):602-5. PMID: 11566939.
      Citations: 5     Fields:    Translation:AnimalsCells
    58. Christopher J, Velarde V, Zhang D, Mayfield D, Mayfield RK, Jaffa AA, Christopher J, Velarde V, Zhang D, Mayfield D, Mayfield RK, Jaffa AA. Regulation of B(2)-kinin receptors by glucose in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2001 Apr; 280(4):H1537-46. PMID: 11247764.
      Citations: 7     Fields:    Translation:AnimalsCells
    59. Mukhin YV, Vlasova T, Jaffa AA, Collinsworth G, Bell JL, Tholanikunnel BG, Pettus T, Fitzgibbon W, Ploth DW, Raymond JR, Garnovskaya MN, Mukhin YV, Vlasova T, Jaffa AA, Collinsworth G, Bell JL, Tholanikunnel BG, Pettus T, Fitzgibbon W, Ploth DW, Raymond JR, Garnovskaya MN. Bradykinin B2 receptors activate Na+/H+ exchange in mIMCD-3 cells via Janus kinase 2 and Ca2+/calmodulin. J Biol Chem. 2001 May 18; 276(20):17339-46. PMID: 11278760.
      Citations: 7     Fields:    Translation:AnimalsCells
    60. Morinelli TA, Webb JG, Jaffa AA, Privitera PJ, Margolius HS, Morinelli TA, Webb JG, Jaffa AA, Privitera PJ, Margolius HS. A metabolic fragment of bradykinin, Arg-Pro-Pro-Gly-Phe, protects against the deleterious effects of lipopolysaccharide in rats. J Pharmacol Exp Ther. 2001 Jan; 296(1):71-6. PMID: 11123364.
      Citations: 2     Fields:    Translation:Animals
    61. Douillet CD, Velarde V, Christopher JT, Mayfield RK, Trojanowska ME, Jaffa AA, Douillet CD, Velarde V, Christopher JT, Mayfield RK, Trojanowska ME, Jaffa AA. Mechanisms by which bradykinin promotes fibrosis in vascular smooth muscle cells: role of TGF-beta and MAPK. Am J Physiol Heart Circ Physiol. 2000 Dec; 279(6):H2829-37. PMID: 11087238.
      Citations: 21     Fields:    Translation:AnimalsCells
    62. Jenkins AJ, Velarde V, Klein RL, Joyce KC, Phillips KD, Mayfield RK, Lyons TJ, Jaffa AA, Jenkins AJ, Velarde V, Klein RL, Joyce KC, Phillips KD, Mayfield RK, Lyons TJ, Jaffa AA. Native and modified LDL activate extracellular signal-regulated kinases in mesangial cells. Diabetes. 2000 Dec; 49(12):2160-9. PMID: 11118021.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    63. Orr RK, Hoehn JL, Col NF, Greene EL, Velarde V, Jaffa AA. Role of reactive oxygen species in bradykinin-induced mitogen-activated protein kinase and c-fos induction in vascular cells. Hypertension. 2000 Apr; 35(4):942-7. PMID: 10775566.
      Citations: 14     Fields:    Translation:AnimalsCells
    64. Naidu PS, Velarde V, Kappler CS, Young RC, Mayfield RK, Jaffa AA, Naidu PS, Velarde V, Kappler CS, Young RC, Mayfield RK, Jaffa AA. Calcium-calmodulin mediates bradykinin-induced MAPK phosphorylation and c-fos induction in vascular cells. Am J Physiol. 1999 09; 277(3):H1061-8. PMID: 10484429.
      Citations: 2     Fields:    Translation:AnimalsCells
    65. Velarde V, Ullian ME, Morinelli TA, Mayfield RK, Jaffa AA, Velarde V, Ullian ME, Morinelli TA, Mayfield RK, Jaffa AA. Mechanisms of MAPK activation by bradykinin in vascular smooth muscle cells. Am J Physiol. 1999 08; 277(2):C253-61. PMID: 10444401.
      Citations: 14     Fields:    Translation:AnimalsCells
    66. Huang Y, Jaffa A, Koskinen S, Takei A, Lopes-Virella MF, Huang Y, Jaffa A, Koskinen S, Takei A, Lopes-Virella MF. Oxidized LDL-containing immune complexes induce Fc gamma receptor I-mediated mitogen-activated protein kinase activation in THP-1 macrophages. Arterioscler Thromb Vasc Biol. 1999 Jul; 19(7):1600-7. PMID: 10397676.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    67. Willi SM, O'Rear D, Garvey WT, Colwell JA, Buse MG, Jaffa A, Lopes-Virella M, Wood D, Mayfield RK, Wallace P, Hermayer KL, Jenkins AJ, Lyons T, Mayer-Davis E, Willi SM, O'Rear D, Garvey WT, Colwell JA, Buse MG, Jaffa A, Lopes-Virella M, Wood D, Mayfield RK, Wallace P, Hermayer KL, Jenkins AJ, Lyons T, Mayer-Davis E. Diabetes research in South Carolina: past, present, and future. J S C Med Assoc. 1998 Nov; 94(11):502-8. PMID: 9844316.
      Citations:    Fields:    Translation:Humans
    68. Vio CP, Oestreicher E, Olavarria V, Velarde V, Mayfield RK, Jaffa AA, Vio CP, Oestreicher E, Olavarria V, Velarde V, Mayfield RK, Jaffa AA. Cellular distribution of exogenous aprotinin in the rat kidney. Biol Chem. 1998 Oct; 379(10):1271-7. PMID: 9820588.
      Citations: 2     Fields:    Translation:Animals
    69. Lu G, Meier KE, Jaffa AA, Rosenzweig SA, Egan BM, Lu G, Meier KE, Jaffa AA, Rosenzweig SA, Egan BM. Oleic acid and angiotensin II induce a synergistic mitogenic response in vascular smooth muscle cells. Hypertension. 1998 Apr; 31(4):978-85. PMID: 9535424.
      Citations: 13     Fields:    Translation:AnimalsCells
    70. Jaffa AA, Miller BS, Rosenzweig SA, Naidu PS, Velarde V, Mayfield RK, Jaffa AA, Miller BS, Rosenzweig SA, Naidu PS, Velarde V, Mayfield RK. Bradykinin induces tubulin phosphorylation and nuclear translocation of MAP kinase in mesangial cells. Am J Physiol. 1997 12; 273(6):F916-24. PMID: 9435680.
      Citations: 4     Fields:    Translation:AnimalsCells
    71. Jaffa AA, Vio C, Velarde V, LeRoith D, Mayfield RK, Jaffa AA, Vio C, Velarde V, LeRoith D, Mayfield RK. Induction of renal kallikrein and renin gene expression by insulin and IGF-I in the diabetic rat. Diabetes. 1997 Dec; 46(12):2049-56. PMID: 9392495.
      Citations: 1     Fields:    Translation:Animals
    72. Morinelli TA, Finley EL, Jaffa AA, Kurtz DT, Ullian ME, Morinelli TA, Finley EL, Jaffa AA, Kurtz DT, Ullian ME. Tyrosine phosphorylation of phosphatidylinositol 3-kinase and of the thromboxane A2 (TXA2) receptor by the TXA2 mimetic I-BOP in A7r5 cells. Biochem Pharmacol. 1997 Jun 15; 53(12):1823-32. PMID: 9256157.
      Citations: 2     Fields:    Translation:Cells
    73. Siragy HM, Jaffa AA, Margolius HS, Siragy HM, Jaffa AA, Margolius HS. Bradykinin B2 receptor modulates renal prostaglandin E2 and nitric oxide. Hypertension. 1997 Mar; 29(3):757-62. PMID: 9052892.
      Citations: 21     Fields:    Translation:Animals
    74. Siragy HM, Jaffa AA, Margolius HS, Carey RM, Siragy HM, Jaffa AA, Margolius HS, Carey RM. Renin-angiotensin system modulates renal bradykinin production. Am J Physiol. 1996 Oct; 271(4 Pt 2):R1090-5. PMID: 8898005.
      Citations: 26     Fields:    Translation:AnimalsCells
    75. Jaffa AA, Silva RH, Kim B, Mayfield RK, Jaffa AA, Silva RH, Kim B, Mayfield RK. Modulation of renal kallikrein production by dietary protein in streptozotocin-induced diabetic rats. J Am Soc Nephrol. 1996 May; 7(5):721-7. PMID: 8738807.
      Citations:    Fields:    Translation:Animals
    76. Fitzgibbon WR, Jaffa AA, Mayfield RK, Ploth DW, Fitzgibbon WR, Jaffa AA, Mayfield RK, Ploth DW. Role of kinins in the renal response to enalaprilat in normotensive and hypertensive rats. Hypertension. 1996 Feb; 27(2):235-44. PMID: 8567046.
      Citations:    Fields:    Translation:Animals
    77. Mayfield RK, Shimojo N, Jaffa AA, Mayfield RK, Shimojo N, Jaffa AA. Skeletal muscle kallikrein. Potential role in metabolic regulation. Diabetes. 1996 Jan; 45 Suppl 1:S20-3. PMID: 8529795.
      Citations: 3     Fields:    Translation:Animals
    78. Jaffa AA, Rust PF, Mayfield RK, Jaffa AA, Rust PF, Mayfield RK. Kinin, a mediator of diabetes-induced glomerular hyperfiltration. Diabetes. 1995 Feb; 44(2):156-60. PMID: 7859934.
      Citations: 10     Fields:    Translation:AnimalsCells
    79. Siragy HM, Ibrahim MM, Jaffa AA, Mayfield R, Margolius HS, Siragy HM, Ibrahim MM, Jaffa AA, Mayfield R, Margolius HS. Rat renal interstitial bradykinin, prostaglandin E2, and cyclic guanosine 3',5'-monophosphate. Effects of altered sodium intake. Hypertension. 1994 Jun; 23(6 Pt 2):1068-70. PMID: 8206596.
      Citations: 15     Fields:    Translation:AnimalsCells
    80. Jaffa AA, LeRoith D, Roberts CT, Rust PF, Mayfield RK, Jaffa AA, LeRoith D, Roberts CT, Rust PF, Mayfield RK. Insulin-like growth factor I produces renal hyperfiltration by a kinin-mediated mechanism. Am J Physiol. 1994 Jan; 266(1 Pt 2):F102-7. PMID: 8304475.
      Citations: 1     Fields:    Translation:AnimalsCells
    81. Siragy HM, Jaffa AA, Margolius HS, Siragy HM, Jaffa AA, Margolius HS. Stimulation of renal interstitial bradykinin by sodium depletion. Am J Hypertens. 1993 Oct; 6(10):863-6. PMID: 8267942.
      Citations: 7     Fields:    Translation:Animals
    82. Hutchison FN, Webster SK, Jaffa AA, Hutchison FN, Webster SK, Jaffa AA. Altered renal kallikrein and renin gene expression in nephrotic rats and modulation by converting enzyme inhibition. J Clin Invest. 1993 Aug; 92(2):1073-9. PMID: 8349789; PMCID: PMC294948.
      Citations: 1     Fields:    Translation:AnimalsCells
    83. Morinelli TA, Tempel GE, Jaffa AA, Silva RH, Naka M, Folger W, Halushka PV, Morinelli TA, Tempel GE, Jaffa AA, Silva RH, Naka M, Folger W, Halushka PV. Thromboxane A2/prostaglandin H2 receptors in streptozotocin-induced diabetes: effects of insulin therapy in the rat. Prostaglandins. 1993 May; 45(5):427-38. PMID: 8321912.
      Citations: 2     Fields:    Translation:AnimalsCells
    84. Harvey JN, Edmundson AW, Jaffa AA, Martin LL, Mayfield RK, Harvey JN, Edmundson AW, Jaffa AA, Martin LL, Mayfield RK. Renal excretion of kallikrein and eicosanoids in patients with type 1 (insulin-dependent) diabetes mellitus. Relationship to glomerular and tubular function. Diabetologia. 1992 Sep; 35(9):857-62. PMID: 1397781.
      Citations: 9     Fields:    Translation:Humans
    85. Jaffa AA, Vio CP, Silva RH, Vavrek RJ, Stewart JM, Rust PF, Mayfield RK, Jaffa AA, Vio CP, Silva RH, Vavrek RJ, Stewart JM, Rust PF, Mayfield RK. Evidence for renal kinins as mediators of amino acid-induced hyperperfusion and hyperfiltration in the rat. J Clin Invest. 1992 May; 89(5):1460-8. PMID: 1373739; PMCID: PMC443016.
      Citations: 3     Fields:    Translation:Animals
    86. Jaffa AA, Chai KX, Chao J, Chao L, Mayfield RK, Jaffa AA, Chai KX, Chao J, Chao L, Mayfield RK. Effects of diabetes and insulin on expression of kallikrein and renin genes in the kidney. Kidney Int. 1992 Apr; 41(4):789-95. PMID: 1513101.
      Citations: 3     Fields:    Translation:Animals
    87. Mayfield RK, Jaffa AA, Edmundson AW, Harvey JN, Mayfield RK, Jaffa AA, Edmundson AW, Harvey JN. Renal hyperfiltration states: relationship to kallikrein and kinins. Agents Actions Suppl. 1992; 38 ( Pt 3):142-8. PMID: 1281377.
      Citations:    Fields:    Translation:Animals
    88. Jaffa AA, Miller DH, Silva RH, Margolius HS, Mayfield RK, Jaffa AA, Miller DH, Silva RH, Margolius HS, Mayfield RK. Regulation of renal kallikrein synthesis and activation by glucocorticoids. Kidney Int. 1990 Aug; 38(2):212-8. PMID: 2205750.
      Citations:    Fields:    Translation:AnimalsCells
    89. Harvey JN, Jaffa AA, Margolius HS, Mayfield RK, Harvey JN, Jaffa AA, Margolius HS, Mayfield RK. Renal kallikrein and hemodynamic abnormalities of diabetic kidney. Diabetes. 1990 Mar; 39(3):299-304. PMID: 1689683.
      Citations: 11     Fields:    Translation:Animals
    90. Jaffa AA, Harvey JN, Sutherland SE, Margolius HS, Mayfield RK, Jaffa AA, Harvey JN, Sutherland SE, Margolius HS, Mayfield RK. Renal kallikrein responses to dietary protein: a possible mediator of hyperfiltration. Kidney Int. 1989 Dec; 36(6):1003-10. PMID: 2601251.
      Citations: 5     Fields:    Translation:Animals
    91. Bolin P, Jaffa AA, Rust PF, Mayfield RK, Bolin P, Jaffa AA, Rust PF, Mayfield RK. Acute and chronic responses of human renal kallikrein and kinins to dietary protein. Am J Physiol. 1989 Nov; 257(5 Pt 2):F718-23. PMID: 2589478.
      Citations: 2     Fields:    Translation:Humans
    92. Jaffa AA, Miller DH, Margolius HS, Mayfield RK, Jaffa AA, Miller DH, Margolius HS, Mayfield RK. The effects of diabetes and insulin on colonic tissue kallikrein. Adv Exp Med Biol. 1989; 247B:669-73. PMID: 2692422.
      Citations:    Fields:    Translation:Animals
    93. Mayfield RK, Sens DA, Jaffa AA, Margolius HS, Mayfield RK, Sens DA, Jaffa AA, Margolius HS. Studies of sweat kallikrein in normal human subjects. Adv Exp Med Biol. 1989; 247B:649-55. PMID: 2610101.
      Citations: 1     Fields:    Translation:Humans
    94. Harvey JN, Jaffa AA, Loadholt CB, Mayfield RK, Harvey JN, Jaffa AA, Loadholt CB, Mayfield RK. Measurement of glomerular filtration rate and renal plasma flow in the diabetic rat by the single-injection isotopic technique: effects of altered distribution volumes of 51Cr-EDTA and 125I-hippuran. Diabetes Res. 1988 Oct; 9(2):67-72. PMID: 3149922.
      Citations: 5     Fields:    Translation:Animals
    95. Jaffa AA, Miller DH, Bailey GS, Chao J, Margolius HS, Mayfield RK, Jaffa AA, Miller DH, Bailey GS, Chao J, Margolius HS, Mayfield RK. Abnormal regulation of renal kallikrein in experimental diabetes. Effects of insulin on prokallikrein synthesis and activation. J Clin Invest. 1987 Dec; 80(6):1651-9. PMID: 3316279; PMCID: PMC442436.
      Citations: 9     Fields:    Translation:AnimalsCells
    96. Jaffa AA, Pratt J, Ashford A, Bailey GS, Jaffa AA, Pratt J, Ashford A, Bailey GS. Studies of the effects of insulin, bradykinin, and captopril on blood glucose levels of alloxan-diabetic rats. Adv Exp Med Biol. 1986; 198 Pt B:373-8. PMID: 3028079.
      Citations:    Fields:    Translation:Animals
    97. Jaffa AA, Hussain M, Rashid Z, Bailey GS, Jaffa AA, Hussain M, Rashid Z, Bailey GS. A comparative study of prokallikreins and kallikreins from rat pancreatic tissue and juice. Adv Exp Med Biol. 1986; 198 Pt A:323-7. PMID: 3643715.
      Citations:    Fields:    Translation:Animals
    98. Orr RK, Hoehn JL, Col NF, Jaffa AA, Pratt J, Ashford A, Bailey GS. A time-course study of submandibular kallikrein, blood glucose and insulin of alloxan-diabetic and streptozotocin-diabetic rats. Agents Actions. 1984 Dec; 15(5-6):478-81. PMID: 6241788.
      Citations: 1     Fields:    Translation:Animals
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