"Protein-Lysine 6-Oxidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme oxidizing peptidyl-lysyl-peptide in the presence of water & molecular oxygen to yield peptidyl-allysyl-peptide plus ammonia & hydrogen peroxide. EC 1.4.3.13.
| Descriptor ID |
D008249
|
| MeSH Number(s) |
D08.811.682.664.500.848
|
| Concept/Terms |
Protein-Lysine 6-Oxidase- Protein-Lysine 6-Oxidase
- 6-Oxidase, Protein-Lysine
- Protein Lysine 6 Oxidase
- Collagen Lysyl Oxidase
- Lysyl Oxidase, Collagen
- Oxidase, Collagen Lysyl
- Lysyl Oxidase
- Oxidase, Lysyl
|
Below are MeSH descriptors whose meaning is more general than "Protein-Lysine 6-Oxidase".
Below are MeSH descriptors whose meaning is more specific than "Protein-Lysine 6-Oxidase".
This graph shows the total number of publications written about "Protein-Lysine 6-Oxidase" by people in this website by year, and whether "Protein-Lysine 6-Oxidase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 2 | 0 | 2 |
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Below are the most recent publications written about "Protein-Lysine 6-Oxidase" by people in Profiles.
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Lysyl oxidase directly contributes to extracellular matrix production and fibrosis in systemic sclerosis. Am J Physiol Lung Cell Mol Physiol. 2021 01 01; 320(1):L29-L40.
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Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer. Nat Commun. 2020 05 15; 11(1):2416.
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Pentagalloyl glucose increases elastin deposition, decreases reactive oxygen species and matrix metalloproteinase activity in pulmonary fibroblasts under inflammatory conditions. Biochem Biophys Res Commun. 2018 04 30; 499(1):24-29.
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Nitric oxide stimulates matrix synthesis and deposition by adult human aortic smooth muscle cells within three-dimensional cocultures. Tissue Eng Part A. 2015 Apr; 21(7-8):1455-70.
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Elasto-regenerative properties of polyphenols. Biochem Biophys Res Commun. 2014 Feb 07; 444(2):205-11.
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Role of endostatin in fibroproliferative disorders.-as a candidate for anti-fibrosis therapy-. Nihon Rinsho Meneki Gakkai Kaishi. 2013; 36(6):452-8.
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A peptide derived from endostatin ameliorates organ fibrosis. Sci Transl Med. 2012 May 30; 4(136):136ra71.
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Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm. Genesis. 2009 Feb; 47(2):115-21.
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Inflammation, but not hypoxia, mediated HIF-1alpha activation depends on COX-2. Cancer Biol Ther. 2009 Jan; 8(1):31-5.
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LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer. Cancer Res. 2007 May 01; 67(9):4123-9.