Carol Feghali-Bostwick

TitleEndowed Chair, Kitty Trask Holt Endowed Chair for Scleroderma Research in the Smart State Center for
InstitutionMedical University of South Carolina
DepartmentRheumatology
AddressP.O. Box MSC 637
CSB-936D
Clinical Science Bldg. - 96 Jonathan Lucas St.
Phone843-876-2315
Fax843-792-7121
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mouawad JE, Sharma S, Renaud L, Pilewski JM, Nadig SN, Feghali-Bostwick C, Mouawad JE, Sharma S, Renaud L, Pilewski JM, Nadig SN, Feghali-Bostwick C. Reduced Cathepsin L expression and secretion into the extracellular milieu contribute to lung fibrosis in systemic sclerosis. Rheumatology (Oxford). 2023 03 01; 62(3):1306-1316. PMID: 35900152.
      Citations: 2     Fields:    Translation:HumansCells
    2. Renaud L, Waldrep KM, da Silveira WA, Pilewski JM, Feghali-Bostwick CA. First Characterization of the Transcriptome of Lung Fibroblasts of SSc Patients and Healthy Donors of African Ancestry. Int J Mol Sci. 2023 Feb 11; 24(4). PMID: 36835058; PMCID: PMC9966000.
      Citations:    Fields:    Translation:HumansCells
    3. Mouawad JE, Feghali-Bostwick C. The Molecular Mechanisms of Systemic Sclerosis-Associated Lung Fibrosis. Int J Mol Sci. 2023 Feb 03; 24(3). PMID: 36769282; PMCID: PMC9917655.
      Citations:    Fields:    Translation:Humans
    4. Richmond JM, Patel D, Watanabe T, Chen HW, Martyanov V, Werner G, Garg M, Haddadi NS, Refat MA, Mahmoud BH, Wong LD, Dresser K, Deng A, Zhu JL, McAlpine W, Hosler GA, Feghali-Bostwick CA, Whitfield ML, Harris JE, Torok KS, Jacobe HT. CXCL9 Links Skin Inflammation and Fibrosis through CXCR3-Dependent Upregulation of Col1a1 in Fibroblasts. J Invest Dermatol. 2023 Jan 25. PMID: 36708947.
      Citations:    Fields:    
    5. Bartlett NW, Feghali-Bostwick C, Gunst SJ. Call for Papers: "Targeting Airway Immunity in Lung Disease". Am J Physiol Lung Cell Mol Physiol. 2023 01 01; 324(1):L48-L52. PMID: 36472349.
      Citations:    Fields:    Translation:Humans
    6. Mouawad JE, Heywood J, Armstrong MB, Ogunleye A, Feghali-Bostwick C. Low Baseline Expression of Fibrotic Genes in an Ex Vivo Human Skin Model is a Potential Indicator of Excessive Skin Scarring. Plast Reconstr Surg Glob Open. 2022 Nov; 10(11):e4626. PMID: 36389611; PMCID: PMC9653186.
      Citations:    
    7. Mlakar L, Garrett SM, Watanabe T, Sanderson M, Nishimoto T, Heywood J, Helke KL, Pilewski JM, Herzog EL, Feghali-Bostwick C. Ameliorating Fibrosis in Murine and Human Tissues with END55, an Endostatin-Derived Fusion Protein Made in Plants. Biomedicines. 2022 Nov 09; 10(11). PMID: 36359382; PMCID: PMC9687961.
      Citations:    
    8. Volkmann ER, Siegfried J, Lahm T, Ventetuolo CE, Mathai SC, Steen V, Herzog EL, Shansky R, Anguera MC, Danoff SK, Giles JT, Lee YC, Drake W, Maier LA, Lachowicz-Scroggins M, Park H, Banerjee K, Fessel J, Reineck L, Vuga L, Crouser E, Feghali-Bostwick C, Volkmann ER, Siegfried J, Lahm T, Ventetuolo CE, Mathai SC, Steen V, Herzog EL, Shansky R, Anguera MC, Danoff SK, Giles JT, Lee YC, Drake W, Maier LA, Lachowicz-Scroggins M, Park H, Banerjee K, Fessel J, Reineck L, Vuga L, Crouser E, Feghali-Bostwick C. Impact of Sex and Gender on Autoimmune Lung Disease: Opportunities for Future Research: NHLBI Working Group Report. Am J Respir Crit Care Med. 2022 10 01; 206(7):817-823. PMID: 35549658; PMCID: PMC9799264.
      Citations:    Fields:    Translation:Humans
    9. Sobecki M, Chen J, Krzywinska E, Nagarajan S, Fan Z, Nelius E, Monn? Rodriguez JM, Seehusen F, Hussein A, Moschini G, Hajam EY, Kiran R, Gotthardt D, Debbache J, Badoual C, Sato T, Isagawa T, Takeda N, Tanchot C, Tartour E, Weber A, Werner S, Loffing J, Sommer L, Sexl V, M?nz C, Feghali-Bostwick C, Pachera E, Distler O, Snedeker J, Jamora C, Stockmann C. Vaccination-based immunotherapy to target profibrotic cells in liver and lung. Cell Stem Cell. 2022 10 06; 29(10):1459-1474.e9. PMID: 36113462.
      Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
    10. Sharma S, Watanabe T, Nishimoto T, Takihara T, Mlakar L, Nguyen XX, Sanderson M, Su Y, Chambers RA, Feghali-Bostwick C, Sharma S, Watanabe T, Nishimoto T, Takihara T, Mlakar L, Nguyen XX, Sanderson M, Su Y, Chambers RA, Feghali-Bostwick C. E4 engages uPAR and enolase-1 and activates urokinase to exert antifibrotic effects. JCI Insight. 2021 12 22; 6(24). PMID: 34935642; PMCID: PMC8783693.
      Citations:    
    11. Takamura N, Renaud L, da Silveira WA, Feghali-Bostwick C, Takamura N, Renaud L, da Silveira WA, Feghali-Bostwick C. PDGF Promotes Dermal Fibroblast Activation via a Novel Mechanism Mediated by Signaling Through MCHR1. Front Immunol. 2021; 12:745308. PMID: 34912333; PMCID: PMC8667318.
      Citations:    
    12. Nguyen XX, Renaud L, Feghali-Bostwick C, Nguyen XX, Renaud L, Feghali-Bostwick C. Identification of Impacted Pathways and Transcriptomic Markers as Potential Mediators of Pulmonary Fibrosis in Transgenic Mice Expressing Human IGFBP5. Int J Mol Sci. 2021 Nov 22; 22(22). PMID: 34830489; PMCID: PMC8619832.
      Citations:    
    13. Loucks TL, Harvey J, Lee-Chavarria D, Paranal R, Lenert KA, Bonilha HS, Feghali-Bostwick C, Loucks TL, Harvey J, Lee-Chavarria D, Paranal R, Lenert KA, Bonilha HS, Feghali-Bostwick C. Clinical and translational research workforce education survey identifies needs of faculty and staff. J Clin Transl Sci. 2022; 6(1):e8. PMID: 35211334; PMCID: PMC8826003.
      Citations:    
    14. Malaab M, Renaud L, Takamura N, Zimmerman KD, da Silveira WA, Ramos PS, Haddad S, Peters-Golden M, Penke LR, Wolf B, Hardiman G, Langefeld CD, Medsger TA, Feghali-Bostwick CA, Malaab M, Renaud L, Takamura N, Zimmerman KD, da Silveira WA, Ramos PS, Haddad S, Peters-Golden M, Penke LR, Wolf B, Hardiman G, Langefeld CD, Medsger TA, Feghali-Bostwick CA. Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis. Ann Rheum Dis. 2022 02; 81(2):268-277. PMID: 34750102; PMCID: PMC8758541.
      Citations:    
    15. Shimoda LA, Bai C, Bartlett NW, Bastarache JA, Feghali-Bostwick C, Gunst SJ, Kuebler WM, Schmidt EP, Morty RE, Shimoda LA, Bai C, Bartlett NW, Bastarache JA, Feghali-Bostwick C, Gunst SJ, Kuebler WM, Schmidt EP, Morty RE. Promoting our early career members at AJP-Lung: the Editorial Board Fellowship Program and the Next Generation Physiologist Highlights section at our Journal. Am J Physiol Lung Cell Mol Physiol. 2021 11 01; 321(5):L844-L846. PMID: 34585617; PMCID: PMC8616620.
      Citations:    
    16. Rudnik M, Hukara A, Kocherova I, Jordan S, Schniering J, Milleret V, Ehrbar M, Klingel K, Feghali-Bostwick C, Distler O, Blyszczuk P, Kania G, Rudnik M, Hukara A, Kocherova I, Jordan S, Schniering J, Milleret V, Ehrbar M, Klingel K, Feghali-Bostwick C, Distler O, Blyszczuk P, Kania G. Elevated Fibronectin Levels in Profibrotic CD14+ Monocytes and CD14+ Macrophages in Systemic Sclerosis. Front Immunol. 2021; 12:642891. PMID: 34504485; PMCID: PMC8421541.
      Citations:    
    17. Pettersson H, Alexanderson H, Poole JL, Varga J, Regardt M, Russell AM, Salam Y, Jensen K, Mansour J, Frech T, Feghali-Bostwick C, Varjú C, Baldwin N, Heenan M, Fligelstone K, Holmner M, Lammi MR, Scholand MB, Shapiro L, Volkmann ER, Saketkoo LA, Pettersson H, Alexanderson H, Poole JL, Varga J, Regardt M, Russell AM, Salam Y, Jensen K, Mansour J, Frech T, Feghali-Bostwick C, Varj? C, Baldwin N, Heenan M, Fligelstone K, Holmner M, Lammi MR, Scholand MB, Shapiro L, Volkmann ER, Saketkoo LA. Exercise as a multi-modal disease-modifying medicine in systemic sclerosis: An introduction by The Global Fellowship on Rehabilitation and Exercise in Systemic Sclerosis (G-FoRSS). Best Pract Res Clin Rheumatol. 2021 09; 35(3):101695. PMID: 34217607; PMCID: PMC8478716.
      Citations:    
    18. Shimoda LA, Bai C, Bartlett NW, Bastarache JA, Feghali-Bostwick C, Kuebler WM, Prakash YS, Schmidt EP, Morty RE, Shimoda LA, Bai C, Bartlett NW, Bastarache JA, Feghali-Bostwick C, Kuebler WM, Prakash YS, Schmidt EP, Morty RE. Announcing the Editorial Board Fellowship Program of the American Journal of Physiology-Lung Cellular and Molecular Physiology. Am J Physiol Lung Cell Mol Physiol. 2021 07 01; 321(1):L116-L118. PMID: 34105373; PMCID: PMC8321860.
      Citations:    
    19. Kendall RT, Renaud L, Baatz JE, Malaab M, Nguyen XX, Feghali-Bostwick CA, Kendall RT, Renaud L, Baatz JE, Malaab M, Nguyen XX, Feghali-Bostwick CA. Systemic sclerosis biomarkers detection in the secretome of TGF?1-activated primary human lung fibroblasts. J Proteomics. 2021 06 30; 242:104243. PMID: 33930553; PMCID: PMC8259054.
      Citations:    
    20. Baker Frost D, Savchenko A, Ogunleye A, Armstrong M, Feghali-Bostwick C, Baker Frost D, Savchenko A, Ogunleye A, Armstrong M, Feghali-Bostwick C. Elucidating the cellular mechanism for E2-induced dermal fibrosis. Arthritis Res Ther. 2021 02 27; 23(1):68. PMID: 33640015; PMCID: PMC7913437.
      Citations:    
    21. Baker Frost D, da Silveira W, Hazard ES, Atanelishvili I, Wilson RC, Flume J, Day KL, Oates JC, Bogatkevich GS, Feghali-Bostwick C, Hardiman G, Ramos PS, Baker Frost D, da Silveira W, Hazard ES, Atanelishvili I, Wilson RC, Flume J, Day KL, Oates JC, Bogatkevich GS, Feghali-Bostwick C, Hardiman G, Ramos PS. Differential DNA Methylation Landscape in Skin Fibroblasts from African Americans with Systemic Sclerosis. Genes (Basel). 2021 01 20; 12(2). PMID: 33498390; PMCID: PMC7909410.
      Citations:    
    22. Nguyen XX, Sanderson M, Helke K, Feghali-Bostwick C, Nguyen XX, Sanderson M, Helke K, Feghali-Bostwick C. Phenotypic Characterization of Transgenic Mice Expressing Human IGFBP-5. Int J Mol Sci. 2020 Dec 30; 22(1). PMID: 33396956; PMCID: PMC7795366.
      Citations:    
    23. Cheikhi AM, Johnson ZI, Julian DR, Wheeler S, Feghali-Bostwick C, Conley YP, Lyons-Weiler J, Yates CC, Cheikhi AM, Johnson ZI, Julian DR, Wheeler S, Feghali-Bostwick C, Conley YP, Lyons-Weiler J, Yates CC. Prediction of severity and subtype of fibrosing disease using model informed by inflammation and extracellular matrix gene index. PLoS One. 2020; 15(10):e0240986. PMID: 33095822; PMCID: PMC7584227.
      Citations:    
    24. Nguyen XX, Nishimoto T, Takihara T, Mlakar L, Bradshaw AD, Feghali-Bostwick C, Nguyen XX, Nishimoto T, Takihara T, Mlakar L, Bradshaw AD, Feghali-Bostwick C. Lysyl oxidase directly contributes to extracellular matrix production and fibrosis in systemic sclerosis. Am J Physiol Lung Cell Mol Physiol. 2021 01 01; 320(1):L29-L40. PMID: 33026236; PMCID: PMC7847064.
      Citations:    
    25. Herro R, Miki H, Sethi GS, Mills D, Mehta AK, Nguyen XX, Feghali-Bostwick C, Miller M, Broide DH, Soloff R, Croft M, Herro R, Miki H, Sethi GS, Mills D, Mehta AK, Nguyen XX, Feghali-Bostwick C, Miller M, Broide DH, Soloff R, Croft M. TL1A Promotes Lung Tissue Fibrosis and Airway Remodeling. J Immunol. 2020 11 01; 205(9):2414-2422. PMID: 32958689; PMCID: PMC7577982.
      Citations:    
    26. Mlakar L, Lane J, Takihara T, Lim C, Sprachman MM, Lloyd KR, Wipf P, Feghali-Bostwick C, Mlakar L, Lane J, Takihara T, Lim C, Sprachman MM, Lloyd KR, Wipf P, Feghali-Bostwick C. Oxetanyl Sulfoxide MMS-350 Ameliorates Pulmonary Fibrosis In Vitro, In Vivo, and Ex Vivo. ACS Med Chem Lett. 2020 Nov 12; 11(11):2312-2317. PMID: 33214846; PMCID: PMC7667835.
      Citations:    
    27. Pachera E, Assassi S, Salazar GA, Stellato M, Renoux F, Wunderlin A, Blyszczuk P, Lafyatis R, Kurreeman F, de Vries-Bouwstra J, Messemaker T, Feghali-Bostwick CA, Rogler G, van Haaften WT, Dijkstra G, Oakley F, Calcagni M, Schniering J, Maurer B, Distler JH, Kania G, Frank-Bertoncelj M, Distler O, Pachera E, Assassi S, Salazar GA, Stellato M, Renoux F, Wunderlin A, Blyszczuk P, Lafyatis R, Kurreeman F, de Vries-Bouwstra J, Messemaker T, Feghali-Bostwick CA, Rogler G, van Haaften WT, Dijkstra G, Oakley F, Calcagni M, Schniering J, Maurer B, Distler JH, Kania G, Frank-Bertoncelj M, Distler O. Long noncoding RNA H19X is a key mediator of TGF-?-driven fibrosis. J Clin Invest. 2020 09 01; 130(9):4888-4905. PMID: 32603313; PMCID: PMC7456219.
      Citations:    
    28. Halushka P, Loucks TL, Paranal R, Harvey J, Briggman K, Lee-Chavarria D, Feghali-Bostwick C, Halushka P, Loucks TL, Paranal R, Harvey J, Briggman K, Lee-Chavarria D, Feghali-Bostwick C. The translational sciences clinic: From bench to bedside. J Clin Transl Sci. 2020 Aug 25; 5(1):e36. PMID: 33948258; PMCID: PMC8057442.
      Citations:    
    29. Feghali-Bostwick C, Feghali-Bostwick C. Pulmonary fibrosis: something old, something new?still waiting for a breakthrough. Am J Physiol Lung Cell Mol Physiol. 2020 09 01; 319(3):L560-L561. PMID: 32755317; PMCID: PMC7518060.
      Citations:    
    30. Tran-Nguyen TK, Xue J, Feghali-Bostwick C, Sciurba FC, Kass DJ, Duncan SR, Tran-Nguyen TK, Xue J, Feghali-Bostwick C, Sciurba FC, Kass DJ, Duncan SR. CD70 Activation Decreases Pulmonary Fibroblast Production of Extracellular Matrix Proteins. Am J Respir Cell Mol Biol. 2020 08; 63(2):255-265. PMID: 32320626; PMCID: PMC7397763.
      Citations:    
    31. Renaud L, da Silveira WA, Takamura N, Hardiman G, Feghali-Bostwick C, Renaud L, da Silveira WA, Takamura N, Hardiman G, Feghali-Bostwick C. Prominence of IL6, IGF, TLR, and Bioenergetics Pathway Perturbation in Lung Tissues of Scleroderma Patients With Pulmonary Fibrosis. Front Immunol. 2020; 11:383. PMID: 32210969; PMCID: PMC7075854.
      Citations:    
    32. Angel PM, Bruner E, Bethard J, Clift CL, Ball L, Drake RR, Feghali-Bostwick C, Angel PM, Bruner E, Bethard J, Clift CL, Ball L, Drake RR, Feghali-Bostwick C. Extracellular matrix alterations in low-grade lung adenocarcinoma compared with normal lung tissue by imaging mass spectrometry. J Mass Spectrom. 2020 Apr; 55(4):e4450. PMID: 31654589; PMCID: PMC7145762.
      Citations:    
    33. Wasson CW, Abignano G, Hermes H, Malaab M, Ross RL, Jimenez SA, Chang HY, Feghali-Bostwick CA, Del Galdo F, Wasson CW, Abignano G, Hermes H, Malaab M, Ross RL, Jimenez SA, Chang HY, Feghali-Bostwick CA, Del Galdo F. Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH. Ann Rheum Dis. 2020 04; 79(4):507-517. PMID: 32041748; PMCID: PMC7147169.
      Citations:    
    34. Nanri Y, Nunomura S, Terasaki Y, Yoshihara T, Hirano Y, Yokosaki Y, Yamaguchi Y, Feghali-Bostwick C, Ajito K, Murakami S, Conway SJ, Izuhara K, Nanri Y, Nunomura S, Terasaki Y, Yoshihara T, Hirano Y, Yokosaki Y, Yamaguchi Y, Feghali-Bostwick C, Ajito K, Murakami S, Conway SJ, Izuhara K. Cross-Talk between Transforming Growth Factor-? and Periostin Can Be Targeted for Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2020 02; 62(2):204-216. PMID: 31505128; PMCID: PMC6993541.
      Citations:    
    35. Yoshihara T, Nanri Y, Nunomura S, Yamaguchi Y, Feghali-Bostwick C, Ajito K, Murakami S, Mawatari M, Izuhara K, Yoshihara T, Nanri Y, Nunomura S, Yamaguchi Y, Feghali-Bostwick C, Ajito K, Murakami S, Mawatari M, Izuhara K. Periostin plays a critical role in the cell cycle in lung fibroblasts. Respir Res. 2020 Jan 30; 21(1):38. PMID: 32000779; PMCID: PMC6993476.
      Citations:    
    36. Argula RG, Ward C, Feghali-Bostwick C, Argula RG, Ward C, Feghali-Bostwick C. Therapeutic Challenges And Advances In The Management Of Systemic Sclerosis-Related Pulmonary Arterial Hypertension (SSc-PAH). Ther Clin Risk Manag. 2019; 15:1427-1442. PMID: 31853179; PMCID: PMC6916691.
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    37. Garrett SM, Hsu E, Thomas JM, Pilewski JM, Feghali-Bostwick C, Garrett SM, Hsu E, Thomas JM, Pilewski JM, Feghali-Bostwick C. Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions. PLoS One. 2019; 14(11):e0225422. PMID: 31765403; PMCID: PMC6876936.
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    38. Schniering J, Benešová M, Brunner M, Haller S, Cohrs S, Frauenfelder T, Vrugt B, Feghali-Bostwick C, Schibli R, Distler O, Müller C, Maurer B, Schniering J, Bene?ov? M, Brunner M, Haller S, Cohrs S, Frauenfelder T, Vrugt B, Feghali-Bostwick C, Schibli R, Distler O, M?ller C, Maurer B. 18F-AzaFol for Detection of Folate Receptor-? Positive Macrophages in Experimental Interstitial Lung Disease-A Proof-of-Concept Study. Front Immunol. 2019; 10:2724. PMID: 31824505; PMCID: PMC6883947.
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    39. Feghali-Bostwick C, Harvey J, Hasseler C, Lee-Chavarria D, Halushka P, Feghali-Bostwick C, Harvey J, Hasseler C, Lee-Chavarria D, Halushka P. A team-based translational journal club: Understanding the translational research highway. J Clin Transl Sci. 2019 Dec; 3(6):291-294. PMID: 31827901; PMCID: PMC6885992.
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    40. van de Vlekkert D, Demmers J, Nguyen XX, Campos Y, Machado E, Annunziata I, Hu H, Gomero E, Qiu X, Bongiovanni A, Feghali-Bostwick CA, d'Azzo A, van de Vlekkert D, Demmers J, Nguyen XX, Campos Y, Machado E, Annunziata I, Hu H, Gomero E, Qiu X, Bongiovanni A, Feghali-Bostwick CA, d'Azzo A. Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis. Sci Adv. 2019 07; 5(7):eaav3270. PMID: 31328155; PMCID: PMC6636989.
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    41. Garrett SM, Zhao Q, Feghali-Bostwick C, Garrett SM, Zhao Q, Feghali-Bostwick C. Induction of a Th17 Phenotype in Human Skin-A Mimic of Dermal Inflammatory Diseases. Methods Protoc. 2019 Jun 04; 2(2). PMID: 31164624; PMCID: PMC6632176.
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    42. Sellares J, Veraldi KL, Thiel KJ, Cárdenes N, Alvarez D, Schneider F, Pilewski JM, Rojas M, Feghali-Bostwick CA, Sellares J, Veraldi KL, Thiel KJ, C?rdenes N, Alvarez D, Schneider F, Pilewski JM, Rojas M, Feghali-Bostwick CA. Intracellular Heat Shock Protein 70 Deficiency in Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2019 06; 60(6):629-636. PMID: 30543447; PMCID: PMC6543745.
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    43. Yasuoka H, Tam YYA, Okazaki Y, Tamura Y, Matsuo K, Feghali-Bostwick C, Takeuchi T, Kuwana M, Yasuoka H, Tam YYA, Okazaki Y, Tamura Y, Matsuo K, Feghali-Bostwick C, Takeuchi T, Kuwana M. Fos-related antigen-1 transgenic mouse as a model for systemic sclerosis: A potential role of M2 polarization. J Scleroderma Relat Disord. 2019 Jun; 4(2):137-148. PMID: 35382387; PMCID: PMC8922645.
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    44. Suryadevara V, Huang L, Kim SJ, Cheresh P, Shaaya M, Bandela M, Fu P, Feghali-Bostwick C, Di Paolo G, Kamp DW, Natarajan V, Suryadevara V, Huang L, Kim SJ, Cheresh P, Shaaya M, Bandela M, Fu P, Feghali-Bostwick C, Di Paolo G, Kamp DW, Natarajan V. Role of phospholipase D in bleomycin-induced mitochondrial reactive oxygen species generation, mitochondrial DNA damage, and pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2019 08 01; 317(2):L175-L187. PMID: 31090437; PMCID: PMC6734379.
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    45. Hadjicharalambous MR, Roux BT, Csomor E, Feghali-Bostwick CA, Murray LA, Clarke DL, Lindsay MA, Hadjicharalambous MR, Roux BT, Csomor E, Feghali-Bostwick CA, Murray LA, Clarke DL, Lindsay MA. Long intergenic non-coding RNAs regulate human lung fibroblast function: Implications for idiopathic pulmonary fibrosis. Sci Rep. 2019 04 15; 9(1):6020. PMID: 30988425; PMCID: PMC6465406.
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    46. Ramos PS, Zimmerman KD, Haddad S, Langefeld CD, Medsger TA, Feghali-Bostwick CA, Ramos PS, Zimmerman KD, Haddad S, Langefeld CD, Medsger TA, Feghali-Bostwick CA. Integrative analysis of DNA methylation in discordant twins unveils distinct architectures of systemic sclerosis subsets. Clin Epigenetics. 2019 04 04; 11(1):58. PMID: 30947741; PMCID: PMC6449959.
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    47. Baker Frost D, Wolf B, Peoples C, Fike J, Silver K, Laffoon M, Medsger TA, Feghali-Bostwick C, Baker Frost D, Wolf B, Peoples C, Fike J, Silver K, Laffoon M, Medsger TA, Feghali-Bostwick C. Estradiol levels are elevated in older men with diffuse cutaneous SSc and are associated with decreased survival. Arthritis Res Ther. 2019 04 02; 21(1):85. PMID: 30940202; PMCID: PMC6444502.
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    48. Yasuoka H, Garrett SM, Nguyen XX, Artlett CM, Feghali-Bostwick CA, Yasuoka H, Garrett SM, Nguyen XX, Artlett CM, Feghali-Bostwick CA. NADPH oxidase-mediated induction of reactive oxygen species and extracellular matrix deposition by insulin-like growth factor binding protein-5. Am J Physiol Lung Cell Mol Physiol. 2019 04 01; 316(4):L644-L655. PMID: 30810066; PMCID: PMC6483014.
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    49. Watanabe T, Baker Frost DA, Mlakar L, Heywood J, da Silveira WA, Hardiman G, Feghali-Bostwick C, Watanabe T, Baker Frost DA, Mlakar L, Heywood J, da Silveira WA, Hardiman G, Feghali-Bostwick C. A Human Skin Model Recapitulates Systemic Sclerosis Dermal Fibrosis and Identifies COL22A1 as a TGF? Early Response Gene that Mediates Fibroblast to Myofibroblast Transition. Genes (Basel). 2019 01 22; 10(2). PMID: 30678304; PMCID: PMC6409682.
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    50. Hadjicharalambous MR, Roux BT, Feghali-Bostwick CA, Murray LA, Clarke DL, Lindsay MA, Hadjicharalambous MR, Roux BT, Feghali-Bostwick CA, Murray LA, Clarke DL, Lindsay MA. Long Non-coding RNAs Are Central Regulators of the IL-1?-Induced Inflammatory Response in Normal and Idiopathic Pulmonary Lung Fibroblasts. Front Immunol. 2018; 9:2906. PMID: 30619270; PMCID: PMC6299252.
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    51. Mullenbrock S, Liu F, Szak S, Hronowski X, Gao B, Juhasz P, Sun C, Liu M, McLaughlin H, Xiao Q, Feghali-Bostwick C, Zheng TS, Mullenbrock S, Liu F, Szak S, Hronowski X, Gao B, Juhasz P, Sun C, Liu M, McLaughlin H, Xiao Q, Feghali-Bostwick C, Zheng TS. Systems Analysis of Transcriptomic and Proteomic Profiles Identifies Novel Regulation of Fibrotic Programs by miRNAs in Pulmonary Fibrosis Fibroblasts. Genes (Basel). 2018 Nov 29; 9(12). PMID: 30501089; PMCID: PMC6316743.
      Citations:    
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    155. Myerburg MM, Latoche JD, McKenna EE, Stabile LP, Siegfried JS, Feghali-Bostwick CA, Pilewski JM, Myerburg MM, Latoche JD, McKenna EE, Stabile LP, Siegfried JS, Feghali-Bostwick CA, Pilewski JM. Hepatocyte growth factor and other fibroblast secretions modulate the phenotype of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 Jun; 292(6):L1352-60. PMID: 17307814.
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    156. Wang XM, Zhang Y, Kim HP, Zhou Z, Feghali-Bostwick CA, Liu F, Ifedigbo E, Xu X, Oury TD, Kaminski N, Choi AM, Wang XM, Zhang Y, Kim HP, Zhou Z, Feghali-Bostwick CA, Liu F, Ifedigbo E, Xu X, Oury TD, Kaminski N, Choi AM. Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. J Exp Med. 2006 Dec 25; 203(13):2895-906. PMID: 17178917; PMCID: PMC1850940.
      Citations:    
    157. Ning W, Dong Y, Sun J, Li C, Matthay MA, Feghali-Bostwick CA, Choi AM, Ning W, Dong Y, Sun J, Li C, Matthay MA, Feghali-Bostwick CA, Choi AM. Cigarette smoke stimulates matrix metalloproteinase-2 activity via EGR-1 in human lung fibroblasts. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):480-90. PMID: 17099140; PMCID: PMC1899323.
      Citations:    
    158. Yasuoka H, Zhou Z, Pilewski JM, Oury TD, Choi AM, Feghali-Bostwick CA, Yasuoka H, Zhou Z, Pilewski JM, Oury TD, Choi AM, Feghali-Bostwick CA. Insulin-like growth factor-binding protein-5 induces pulmonary fibrosis and triggers mononuclear cellular infiltration. Am J Pathol. 2006 Nov; 169(5):1633-42. PMID: 17071587; PMCID: PMC1780193.
      Citations:    
    159. Fischer A, Meehan RT, Feghali-Bostwick CA, West SG, Brown KK, Fischer A, Meehan RT, Feghali-Bostwick CA, West SG, Brown KK. Unique characteristics of systemic sclerosis sine scleroderma-associated interstitial lung disease. Chest. 2006 Oct; 130(4):976-81. PMID: 17035427.
      Citations:    
    160. Yasuoka H, Jukic DM, Zhou Z, Choi AM, Feghali-Bostwick CA, Yasuoka H, Jukic DM, Zhou Z, Choi AM, Feghali-Bostwick CA. Insulin-like growth factor binding protein 5 induces skin fibrosis: A novel murine model for dermal fibrosis. Arthritis Rheum. 2006 Sep; 54(9):3001-10. PMID: 16947625.
      Citations:    
    161. Fischer A, Pfalzgraf FJ, Feghali-Bostwick CA, Wright TM, Curran-Everett D, West SG, Brown KK, Fischer A, Pfalzgraf FJ, Feghali-Bostwick CA, Wright TM, Curran-Everett D, West SG, Brown KK. Anti-th/to-positivity in a cohort of patients with idiopathic pulmonary fibrosis. J Rheumatol. 2006 Aug; 33(8):1600-5. PMID: 16783860.
      Citations:    
    162. Ning W, Lee J, Kaminski N, Feghali-Bostwick CA, Watkins SC, Pilewski JM, Peters DG, Hogg JC, Choi AM, Ning W, Lee J, Kaminski N, Feghali-Bostwick CA, Watkins SC, Pilewski JM, Peters DG, Hogg JC, Choi AM. Comprehensive analysis of gene expression on GOLD-2 Versus GOLD-0 smokers reveals novel genes important in the pathogenesis of COPD. Proc Am Thorac Soc. 2006 Aug; 3(6):466. PMID: 16921106.
      Citations:    
    163. Xiong M, Feghali-Bostwick CA, Arnett FC, Zhou X, Xiong M, Feghali-Bostwick CA, Arnett FC, Zhou X. A systems biology approach to genetic studies of complex diseases. FEBS Lett. 2005 Oct 10; 579(24):5325-32. PMID: 16182293.
      Citations:    
    164. Zhou X, Tan FK, Xiong M, Arnett FC, Feghali-Bostwick CA, Zhou X, Tan FK, Xiong M, Arnett FC, Feghali-Bostwick CA. Monozygotic twins clinically discordant for scleroderma show concordance for fibroblast gene expression profiles. Arthritis Rheum. 2005 Oct; 52(10):3305-14. PMID: 16200604.
      Citations:    
    165. Feghali-Bostwick CA, Feghali-Bostwick CA. IGF-I: mediator of fibrosis or carcinogenesis? Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L803-4. PMID: 15821020.
      Citations:    
    166. Feghali-Bostwick CA, Feghali-Bostwick CA. Genetics and proteomics in scleroderma. Curr Rheumatol Rep. 2005 Apr; 7(2):129-34. PMID: 15760592.
      Citations:    
    167. Pilewski JM, Liu L, Henry AC, Knauer AV, Feghali-Bostwick CA, Pilewski JM, Liu L, Henry AC, Knauer AV, Feghali-Bostwick CA. Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition. Am J Pathol. 2005 Feb; 166(2):399-407. PMID: 15681824; PMCID: PMC1602317.
      Citations:    
    168. Ning W, Li CJ, Kaminski N, Feghali-Bostwick CA, Alber SM, Di YP, Otterbein SL, Song R, Hayashi S, Zhou Z, Pinsky DJ, Watkins SC, Pilewski JM, Sciurba FC, Peters DG, Hogg JC, Choi AM, Ning W, Li CJ, Kaminski N, Feghali-Bostwick CA, Alber SM, Di YP, Otterbein SL, Song R, Hayashi S, Zhou Z, Pinsky DJ, Watkins SC, Pilewski JM, Sciurba FC, Peters DG, Hogg JC, Choi AM. Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A. 2004 Oct 12; 101(41):14895-900. PMID: 15469929; PMCID: PMC522001.
      Citations:    
    169. Bogatkevich GS, Gustilo E, Oates JC, Feghali-Bostwick C, Harley RA, Silver RM, Ludwicka-Bradley A, Bogatkevich GS, Gustilo E, Oates JC, Feghali-Bostwick C, Harley RA, Silver RM, Ludwicka-Bradley A. Distinct PKC isoforms mediate cell survival and DNA synthesis in thrombin-induced myofibroblasts. Am J Physiol Lung Cell Mol Physiol. 2005 Jan; 288(1):L190-201. PMID: 15447940.
      Citations:    
    170. Parks CG, Pandey JP, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS, Feghali-Bostwick CA, Feghali-Botswick CL, Cooper GS, Parks CG, Pandey JP, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS, Feghali-Bostwick CA, Feghali-Botswick CL, Cooper GS. Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic lupus erythematosus: associations and interaction with the interleukin-1alpha-889 C/T polymorphism. Hum Immunol. 2004 Jun; 65(6):622-31. PMID: 15219382.
      Citations:    
    171. Hu B, Wang S, Zhang Y, Feghali CA, Dingman JR, Wright TM, Hu B, Wang S, Zhang Y, Feghali CA, Dingman JR, Wright TM. A nuclear target for interleukin-1alpha: interaction with the growth suppressor necdin modulates proliferation and collagen expression. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):10008-13. PMID: 12913118; PMCID: PMC187743.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    172. Feghali-Bostwick C, Medsger TA, Wright TM, Feghali-Bostwick C, Medsger TA, Wright TM. Analysis of systemic sclerosis in twins reveals low concordance for disease and high concordance for the presence of antinuclear antibodies. Arthritis Rheum. 2003 Jul; 48(7):1956-63. PMID: 12847690.
      Citations: 76     Fields:    Translation:Humans
    173. Zhou X, Tan FK, Xiong M, Milewicz DM, Feghali CA, Fritzler MJ, Reveille JD, Arnett FC, Zhou X, Tan FK, Xiong M, Milewicz DM, Feghali CA, Fritzler MJ, Reveille JD, Arnett FC. Systemic sclerosis (scleroderma): specific autoantigen genes are selectively overexpressed in scleroderma fibroblasts. J Immunol. 2001 Dec 15; 167(12):7126-33. PMID: 11739535.
      Citations: 20     Fields:    Translation:HumansCells
    174. Kuwana M, Feghali CA, Medsger TA, Wright TM, Kuwana M, Feghali CA, Medsger TA, Wright TM. Autoreactive T cells to topoisomerase I in monozygotic twins discordant for systemic sclerosis. Arthritis Rheum. 2001 Jul; 44(7):1654-9. PMID: 11465716.
      Citations: 7     Fields:    Translation:HumansCells
    175. Feghali CA, Wright TM, Feghali CA, Wright TM. Identification of multiple, differentially expressed messenger RNAs in dermal fibroblasts from patients with systemic sclerosis. Arthritis Rheum. 1999 Jul; 42(7):1451-7. PMID: 10403273.
      Citations: 35     Fields:    Translation:HumansCells
    176. Feghali CA, Wright TM, Feghali CA, Wright TM. Cytokines in acute and chronic inflammation. Front Biosci. 1997 Jan 01; 2:d12-26. PMID: 9159205.
      Citations: 277     Fields:    Translation:HumansAnimals
    177. Guyer NB, Severns CW, Wong P, Feghali CA, Wright TM, Guyer NB, Severns CW, Wong P, Feghali CA, Wright TM. IFN-gamma induces a p91/Stat1 alpha-related transcription factor with distinct activation and binding properties. J Immunol. 1995 Oct 01; 155(7):3472-80. PMID: 7561042.
      Citations: 11     Fields:    Translation:HumansCells
    178. Feghali CA, Wright TM, Feghali CA, Wright TM. Ligand-dependent and -independent activation of the transcription factor gamma RF-1 in a cell-free system. Biochem J. 1995 Sep 01; 310 ( Pt 2):461-7. PMID: 7544574; PMCID: PMC1135918.
      Citations: 1     Fields:    Translation:HumansCells
    179. Feghali CA, Bost KL, Boulware DW, Levy LS, Feghali CA, Bost KL, Boulware DW, Levy LS. Control of IL-6 expression and response in fibroblasts from patients with systemic sclerosis. Autoimmunity. 1994; 17(4):309-18. PMID: 7948613.
      Citations: 14     Fields:    Translation:HumansCells
    180. Feghali CA, Boulware DW, Ferriss JA, Levy LS, Feghali CA, Boulware DW, Ferriss JA, Levy LS. Expression of c-myc, c-myb, and c-sis in fibroblasts from affected and unaffected skin of patients with systemic sclerosis. Autoimmunity. 1993; 16(3):167-71. PMID: 8003611.
      Citations: 1     Fields:    Translation:HumansCells
    181. Feghali CA, Boulware DW, Levy LS, Feghali CA, Boulware DW, Levy LS. Mechanisms of pathogenesis in scleroderma. II. Effects of serum and conditioned culture medium on fibroblast function in scleroderma. J Rheumatol. 1992 Aug; 19(8):1212-9. PMID: 1404156.
      Citations:    Fields:    Translation:HumansCells
    182. Feghali CA, Bost KL, Boulware DW, Levy LS, Feghali CA, Bost KL, Boulware DW, Levy LS. Mechanisms of pathogenesis in scleroderma. I. Overproduction of interleukin 6 by fibroblasts cultured from affected skin sites of patients with scleroderma. J Rheumatol. 1992 Aug; 19(8):1207-11. PMID: 1404155.
      Citations: 50     Fields:    Translation:HumansCells
    183. Feghali CA, Bost KL, Boulware DW, Levy LS, Feghali CA, Bost KL, Boulware DW, Levy LS. Human recombinant interleukin-4 induces proliferation and interleukin-6 production by cultured human skin fibroblasts. Clin Immunol Immunopathol. 1992 May; 63(2):182-7. PMID: 1611720.
      Citations: 10     Fields:    Translation:HumansCells
    184. Dang H, Dauphinée MJ, Talal N, Garry RF, Seibold JR, Medsger TA, Alexander S, Feghali CA, Dang H, Dauphin?e MJ, Talal N, Garry RF, Seibold JR, Medsger TA, Alexander S, Feghali CA. Serum antibody to retroviral gag proteins in systemic sclerosis. Arthritis Rheum. 1991 Oct; 34(10):1336-7. PMID: 1930323.
      Citations: 8     Fields:    Translation:HumansCells
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