"Protein-Lysine 6-Oxidase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme oxidizing peptidyl-lysyl-peptide in the presence of water & molecular oxygen to yield peptidyl-allysyl-peptide plus ammonia & hydrogen peroxide. EC 1.4.3.13.
| Descriptor ID |
D008249
|
| MeSH Number(s) |
D08.811.682.664.500.848
|
| Concept/Terms |
Protein-Lysine 6-Oxidase- Protein-Lysine 6-Oxidase
- 6-Oxidase, Protein-Lysine
- Protein Lysine 6 Oxidase
- Collagen Lysyl Oxidase
- Lysyl Oxidase, Collagen
- Oxidase, Collagen Lysyl
- Lysyl Oxidase
- Oxidase, Lysyl
|
Below are MeSH descriptors whose meaning is more general than "Protein-Lysine 6-Oxidase".
Below are MeSH descriptors whose meaning is more specific than "Protein-Lysine 6-Oxidase".
This graph shows the total number of publications written about "Protein-Lysine 6-Oxidase" by people in this website by year, and whether "Protein-Lysine 6-Oxidase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2009 | 1 | 1 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2020 | 2 | 0 | 2 |
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Below are the most recent publications written about "Protein-Lysine 6-Oxidase" by people in Profiles.
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Nguyen XX, Nishimoto T, Takihara T, Mlakar L, Bradshaw AD, Feghali-Bostwick C. Lysyl oxidase directly contributes to extracellular matrix production and fibrosis in systemic sclerosis. Am J Physiol Lung Cell Mol Physiol. 2021 01 01; 320(1):L29-L40.
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Saatci O, Kaymak A, Raza U, Ersan PG, Akbulut O, Banister CE, Sikirzhytski V, Tokat UM, Aykut G, Ansari SA, Dogan HT, Dogan M, Jandaghi P, Isik A, Gundogdu F, Kosemehmetoglu K, Dizdar O, Aksoy S, Akyol A, Uner A, Buckhaults PJ, Riazalhosseini Y, Sahin O. Targeting lysyl oxidase (LOX) overcomes chemotherapy resistance in triple negative breast cancer. Nat Commun. 2020 05 15; 11(1):2416.
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Parasaram V, Nosoudi N, Chowdhury A, Vyavahare N. Pentagalloyl glucose increases elastin deposition, decreases reactive oxygen species and matrix metalloproteinase activity in pulmonary fibroblasts under inflammatory conditions. Biochem Biophys Res Commun. 2018 04 30; 499(1):24-29.
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Simmers P, Gishto A, Vyavahare N, Kothapalli CR. Nitric oxide stimulates matrix synthesis and deposition by adult human aortic smooth muscle cells within three-dimensional cocultures. Tissue Eng Part A. 2015 Apr; 21(7-8):1455-70.
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Sinha A, Nosoudi N, Vyavahare N. Elasto-regenerative properties of polyphenols. Biochem Biophys Res Commun. 2014 Feb 07; 444(2):205-11.
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Yamaguchi Y, Feghali-Bostwick CA. Role of endostatin in fibroproliferative disorders.-as a candidate for anti-fibrosis therapy-. Nihon Rinsho Meneki Gakkai Kaishi. 2013; 36(6):452-8.
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Yamaguchi Y, Takihara T, Chambers RA, Veraldi KL, Larregina AT, Feghali-Bostwick CA. A peptide derived from endostatin ameliorates organ fibrosis. Sci Transl Med. 2012 May 30; 4(136):136ra71.
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Choudhary B, Zhou J, Li P, Thomas S, Kaartinen V, Sucov HM. Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm. Genesis. 2009 Feb; 47(2):115-21.
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Stasinopoulos I, O'Brien DR, Bhujwalla ZM. Inflammation, but not hypoxia, mediated HIF-1alpha activation depends on COX-2. Cancer Biol Ther. 2009 Jan; 8(1):31-5.
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Wu G, Guo Z, Chang X, Kim MS, Nagpal JK, Liu J, Maki JM, Kivirikko KI, Ethier SP, Trink B, Sidransky D. LOXL1 and LOXL4 are epigenetically silenced and can inhibit ras/extracellular signal-regulated kinase signaling pathway in human bladder cancer. Cancer Res. 2007 May 01; 67(9):4123-9.