Narcolepsy

"Narcolepsy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A condition characterized by recurrent episodes of daytime somnolence and lapses in consciousness (microsomnias) that may be associated with automatic behaviors and AMNESIA. CATAPLEXY; SLEEP PARALYSIS, and hypnagogic HALLUCINATIONS frequently accompany narcolepsy. The pathophysiology of this disorder includes sleep-onset rapid eye movement (REM) sleep, which normally follows stage III or IV sleep. (From Neurology 1998 Feb;50(2 Suppl 1):S2-S7)

Descriptor ID	D009290
MeSH Number(s)	C10.886.425.800.200.750 F03.870.400.800.200.750
Concept/Terms	Narcolepsy Narcolepsy Paroxysmal Sleep Sleep, Paroxysmal Narcoleptic Syndrome Narcoleptic Syndromes Syndrome, Narcoleptic Syndromes, Narcoleptic Gelineau Syndrome Syndrome, Gelineau Gelineau's Syndrome Gelineau's Syndromes Gelineaus Syndrome Syndrome, Gelineau's Syndromes, Gelineau's Narcolepsy-Cataplexy Syndrome Narcolepsy-Cataplexy Syndrome Narcolepsy Cataplexy Syndrome Narcolepsy-Cataplexy Syndromes Syndrome, Narcolepsy-Cataplexy Syndromes, Narcolepsy-Cataplexy

Below are MeSH descriptors whose meaning is more general than "Narcolepsy".

Diseases [C]
Nervous System Diseases [C10]
Sleep Wake Disorders [C10.886]
Dyssomnias [C10.886.425]
Sleep Disorders, Intrinsic [C10.886.425.800]
Disorders of Excessive Somnolence [C10.886.425.800.200]
Narcolepsy [C10.886.425.800.200.750]
Psychiatry and Psychology [F]
Mental Disorders [F03]
Sleep Wake Disorders [F03.870]
Dyssomnias [F03.870.400]
Sleep Disorders, Intrinsic [F03.870.400.800]
Disorders of Excessive Somnolence [F03.870.400.800.200]
Narcolepsy [F03.870.400.800.200.750]

Below are MeSH descriptors whose meaning is related to "Narcolepsy".

Below are MeSH descriptors whose meaning is more specific than "Narcolepsy".

Narcolepsy
Cataplexy

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Narcolepsy" by people in this website by year, and whether "Narcolepsy" was a major or minor topic of these publications.

Bar chart showing 32 publications over 17 distinct years, with a maximum of 4 publications in 2003

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	1	0	1
2001	0	3	3
2003	3	1	4
2004	2	0	2
2005	1	0	1
2007	1	1	2
2008	2	0	2
2009	1	0	1
2011	1	0	1
2013	1	0	1
2015	2	1	3
2016	2	0	2
2017	3	0	3
2018	1	0	1
2019	2	0	2
2021	1	0	1
2022	2	0	2

Below are the most recent publications written about "Narcolepsy" by people in Profiles.

Dauvilliers Y, Šonka K, Bogan RK, Partinen M, Del Rio Villegas R, Foldvary-Schaefer N, Skowronski R, Chen A, Black J, Skobieranda F, Thorpy MJ. Changes in Cataplexy Frequency in a Clinical Trial of Lower-Sodium Oxybate with Taper and Discontinuation of Other Anticataplectic Medications. CNS Drugs. 2022 06; 36(6):633-647.

View in: PubMed
Roth T, Dauvilliers Y, Thorpy MJ, Kushida C, Corser BC, Bogan R, Rosenberg R, Dubow J, Seiden D. Effect of FT218, a Once-Nightly Sodium Oxybate Formulation, on Disrupted Nighttime Sleep in Patients with Narcolepsy: Results from the Randomized Phase III REST-ON Trial. CNS Drugs. 2022 04; 36(4):377-387.

View in: PubMed
Bogan RK, Thorpy MJ, Dauvilliers Y, Partinen M, Del Rio Villegas R, Foldvary-Schaefer N, Skowronski R, Tang L, Skobieranda F, Šonka K. Efficacy and safety of calcium, magnesium, potassium, and sodium oxybates (lower-sodium oxybate [LXB]; JZP-258) in a placebo-controlled, double-blind, randomized withdrawal study in adults with narcolepsy with cataplexy. Sleep. 2021 03 12; 44(3).

View in: PubMed
Thorpy MJ, Bogan RK. Update on the pharmacologic management of narcolepsy: mechanisms of action and clinical implications. Sleep Med. 2020 04; 68:97-109.

View in: PubMed
Sun Y, Blanco-Centurion C, Bendell E, Vidal-Ortiz A, Luo S, Liu M. Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy. Elife. 2019 08 14; 8.

View in: PubMed
Ohayon MM, Black J, Krystal AD, Shapiro CM, Swick TJ, Bogan R, Wells CC. Longitudinal study of narcolepsy symptoms in first, second, and third-degree relatives of simplex and multiplex narcolepsy families. Sleep Med. 2019 01; 53:88-93.

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Liu M, Blanco-Centurion C, Shiromani PJ. Rewiring brain circuits to block cataplexy in murine models of narcolepsy. Curr Opin Neurobiol. 2017 06; 44:110-115.

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Ruoff C, Bogan RK, Emsellem H, Feldman N, Lankford A, Bream G, Khayrallah M, Lu Y, Carter LP, Black J. Evaluation of the effect of JZP-110 in patients with narcolepsy assessed using the Maintenance of Wakefulness Test censored to 20 minutes. Sleep Med. 2017 Jul; 35:12-16.

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Cairns A, Bogan R. Underutilization of the MSLT in sleepy patients with a short onset REM period (SOREMP) in the sleep clinic. Sleep Med. 2017 Apr; 32:150-156.

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Hartmann FJ, Bernard-Valnet R, Quériault C, Mrdjen D, Weber LM, Galli E, Krieg C, Robinson MD, Nguyen XH, Dauvilliers Y, Liblau RS, Becher B. High-dimensional single-cell analysis reveals the immune signature of narcolepsy. J Exp Med. 2016 11 14; 213(12):2621-2633.

View in: PubMed

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