"Lewy Bodies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. They are typically found in the substantia nigra and locus coeruleus but they are also seen in the basal forebrain, hypothalamic nuclei, and neocortex.
| Descriptor ID |
D016631
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| MeSH Number(s) |
A08.675.460 A11.284.420.460 A11.671.460
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Lewy Bodies".
Below are MeSH descriptors whose meaning is more specific than "Lewy Bodies".
This graph shows the total number of publications written about "Lewy Bodies" by people in this website by year, and whether "Lewy Bodies" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 1997 | 2 | 0 | 2 |
| 2001 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Lewy Bodies" by people in Profiles.
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Burgut FT, Kellner CH. Electroconvulsive therapy (ECT) for dementia with Lewy bodies. Med Hypotheses. 2010 Aug; 75(2):139-40.
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von Coelln R, Thomas B, Andrabi SA, Lim KL, Savitt JM, Saffary R, Stirling W, Bruno K, Hess EJ, Lee MK, Dawson VL, Dawson TM. Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy. J Neurosci. 2006 Apr 05; 26(14):3685-96.
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Johnston BT, Colcher A, Li Q, Gideon RM, Castell JA, Castell DO. Repetitive proximal esophageal contractions: a new manometric finding and a possible further link between Parkinson's disease and achalasia. Dysphagia. 2001; 16(3):186-9.
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Tompkins MM, Hill WD. Contribution of somal Lewy bodies to neuronal death. Brain Res. 1997 Nov 14; 775(1-2):24-9.
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Tompkins MM, Basgall EJ, Zamrini E, Hill WD. Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons. Am J Pathol. 1997 Jan; 150(1):119-31.
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Hill WD, Arai M, Cohen JA, Trojanowski JQ. Neurofilament mRNA is reduced in Parkinson's disease substantia nigra pars compacta neurons. J Comp Neurol. 1993 Mar 15; 329(3):328-36.
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Arai H, Lee VM, Hill WD, Greenberg BD, Trojanowski JQ. Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease. Brain Res. 1992 Jul 10; 585(1-2):386-90.