"Lewy Bodies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. They are typically found in the substantia nigra and locus coeruleus but they are also seen in the basal forebrain, hypothalamic nuclei, and neocortex.
| Descriptor ID |
D016631
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| MeSH Number(s) |
A08.675.460 A11.284.420.460 A11.671.460
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Lewy Bodies".
Below are MeSH descriptors whose meaning is more specific than "Lewy Bodies".
This graph shows the total number of publications written about "Lewy Bodies" by people in this website by year, and whether "Lewy Bodies" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 2 | 0 | 2 |
| 2001 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
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Below are the most recent publications written about "Lewy Bodies" by people in Profiles.
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Electroconvulsive therapy (ECT) for dementia with Lewy bodies. Med Hypotheses. 2010 Aug; 75(2):139-40.
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Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy. J Neurosci. 2006 Apr 05; 26(14):3685-96.
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Repetitive proximal esophageal contractions: a new manometric finding and a possible further link between Parkinson's disease and achalasia. Dysphagia. 2001; 16(3):186-9.
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Contribution of somal Lewy bodies to neuronal death. Brain Res. 1997 Nov 14; 775(1-2):24-9.
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Apoptotic-like changes in Lewy-body-associated disorders and normal aging in substantia nigral neurons. Am J Pathol. 1997 Jan; 150(1):119-31.
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Neurofilament mRNA is reduced in Parkinson's disease substantia nigra pars compacta neurons. J Comp Neurol. 1993 Mar 15; 329(3):328-36.
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Lewy bodies contain beta-amyloid precursor proteins of Alzheimer's disease. Brain Res. 1992 Jul 10; 585(1-2):386-90.