Ryanodine Receptor Calcium Release Channel
"Ryanodine Receptor Calcium Release Channel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tetrameric calcium release channel in the SARCOPLASMIC RETICULUM membrane of SMOOTH MUSCLE CELLS, acting oppositely to SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE. Abnormalities are implicated in CARDIAC ARRHYTHMIAS and MUSCULAR DISEASES.
| Descriptor ID |
D019837
|
| MeSH Number(s) |
D12.776.157.530.400.150.800 D12.776.210.500.800 D12.776.543.550.450.150.800 D12.776.543.585.400.150.800
|
| Concept/Terms |
Ryanodine Receptor Calcium Release Channel- Ryanodine Receptor Calcium Release Channel
- Receptor, Ryanodine
- Ca Release Channel-Ryanodine Receptor
- Ca Release Channel Ryanodine Receptor
- Calcium-Ryanodine Receptor Complex
- Calcium Ryanodine Receptor Complex
- Complex, Calcium-Ryanodine Receptor
- Receptor Complex, Calcium-Ryanodine
- Ryanodine Receptor
|
Below are MeSH descriptors whose meaning is more general than "Ryanodine Receptor Calcium Release Channel".
Below are MeSH descriptors whose meaning is more specific than "Ryanodine Receptor Calcium Release Channel".
This graph shows the total number of publications written about "Ryanodine Receptor Calcium Release Channel" by people in this website by year, and whether "Ryanodine Receptor Calcium Release Channel" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2003 | 3 | 1 | 4 |
| 2004 | 1 | 0 | 1 |
| 2005 | 2 | 0 | 2 |
| 2006 | 1 | 1 | 2 |
| 2007 | 3 | 0 | 3 |
| 2008 | 2 | 1 | 3 |
| 2009 | 1 | 0 | 1 |
| 2010 | 2 | 0 | 2 |
| 2011 | 3 | 0 | 3 |
| 2012 | 1 | 1 | 2 |
| 2013 | 2 | 1 | 3 |
| 2014 | 2 | 2 | 4 |
| 2015 | 0 | 3 | 3 |
| 2016 | 3 | 1 | 4 |
| 2017 | 1 | 1 | 2 |
| 2018 | 2 | 0 | 2 |
| 2019 | 1 | 0 | 1 |
| 2020 | 2 | 0 | 2 |
| 2021 | 1 | 0 | 1 |
| 2022 | 2 | 0 | 2 |
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Below are the most recent publications written about "Ryanodine Receptor Calcium Release Channel" by people in Profiles.
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Do CPVT-linked mutations alter RYR2 regulation by cytosolic Ca2+ in cardiomyocytes? J Gen Physiol. 2022 09 05; 154(9).
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CRISPR/Cas9 Gene Editing of RYR2 in Human iPSC-Derived Cardiomyocytes to Probe Ca2+ Signaling Aberrancies of CPVT Arrhythmogenesis. Methods Mol Biol. 2022; 2573:41-52.
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Mutation in RyR2-FKBP Binding site alters Ca2+ signaling modestly but increases "arrhythmogenesis" in human stem cells derived cardiomyocytes. Cell Calcium. 2022 01; 101:102500.
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Calcium signaling consequences of RyR2 mutations associated with CPVT1 introduced via CRISPR/Cas9 gene editing in human-induced pluripotent stem cell-derived cardiomyocytes: Comparison of RyR2-R420Q, F2483I, and Q4201R. Heart Rhythm. 2021 02; 18(2):250-260.
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Molecular Insights into Calcium Dependent Regulation of Ryanodine Receptor Calcium Release Channels. Adv Exp Med Biol. 2020; 1131:321-336.
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A central core disease mutation in the Ca2+-binding site of skeletal muscle ryanodine receptor impairs single-channel regulation. Am J Physiol Cell Physiol. 2019 08 01; 317(2):C358-C365.
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Ca2+-mediated activation of the skeletal-muscle ryanodine receptor ion channel. J Biol Chem. 2018 12 14; 293(50):19501-19509.
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CRISPR/Cas9 Gene editing of RyR2 in human stem cell-derived cardiomyocytes provides a novel approach in investigating dysfunctional Ca2+ signaling. Cell Calcium. 2018 07; 73:104-111.
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Cross-species molecular dissection across alcohol behavioral domains. Alcohol. 2018 11; 72:19-31.
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Two EF-hand motifs in ryanodine receptor calcium release channels contribute to isoform-specific regulation by calmodulin. Cell Calcium. 2017 09; 66:62-70.