Myogenic Regulatory Factors
"Myogenic Regulatory Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of muscle-specific transcription factors which bind to DNA in control regions and thus regulate myogenesis. All members of this family contain a conserved helix-loop-helix motif which is homologous to the myc family proteins. These factors are only found in skeletal muscle. Members include the myoD protein (MYOD PROTEIN); MYOGENIN; myf-5, and myf-6 (also called MRF4 or herculin).
| Descriptor ID |
D018006
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| MeSH Number(s) |
D12.776.210.500.570 D12.776.260.103.750 D12.776.930.125.750
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Myogenic Regulatory Factors".
Below are MeSH descriptors whose meaning is more specific than "Myogenic Regulatory Factors".
This graph shows the total number of publications written about "Myogenic Regulatory Factors" by people in this website by year, and whether "Myogenic Regulatory Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 2 | 3 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
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Below are the most recent publications written about "Myogenic Regulatory Factors" by people in Profiles.
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Mef2c regulates transcription of the extracellular matrix protein cartilage link protein 1 in the developing murine heart. PLoS One. 2013; 8(2):e57073.
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Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell. 2012 Dec 21; 151(7):1581-94.
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IL-4R drives dedifferentiation, mitogenesis, and metastasis in rhabdomyosarcoma. Clin Cancer Res. 2011 May 01; 17(9):2757-66.
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Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2. Neuron. 2010 Apr 29; 66(2):191-7.
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MicroRNA-1 negatively regulates expression of the hypertrophy-associated calmodulin and Mef2a genes. Mol Cell Biol. 2009 Apr; 29(8):2193-204.
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Regulation of synaptic connectivity with chronic cocaine. Am J Psychiatry. 2008 Nov; 165(11):1393.
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Neuroscience: Brain's defence against cocaine. Nature. 2008 Oct 09; 455(7214):743-4.
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Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron. 2008 Aug 28; 59(4):621-33.
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Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science. 2006 Feb 17; 311(5763):1008-12.
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A novel role for extracellular signal-regulated kinase 5 and myocyte enhancer factor 2 in medulloblastoma cell death. Cancer Res. 2005 Jul 01; 65(13):5683-9.