Receptors, GABA-A

"Receptors, GABA-A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. The receptors belong to a superfamily that share a common CYSTEINE loop.

Descriptor ID	D011963
MeSH Number(s)	D12.776.157.530.400.175.562 D12.776.157.530.400.400.100.100 D12.776.543.550.450.175.562 D12.776.543.550.450.500.100.100 D12.776.543.585.400.175.562 D12.776.543.585.400.500.100.100 D12.776.543.750.130.500 D12.776.543.750.720.200.300.300
Concept/Terms	Receptors, GABA-A Receptors, GABA-A Receptors, GABA A GABA-A Receptor GABA A Receptor Receptor, GABA-A GABA-A Receptors GABA A Receptors gamma-Aminobutyric Acid Subtype A Receptors gamma Aminobutyric Acid Subtype A Receptors Muscimol Receptor Receptor, Muscimol Receptors, Benzodiazepine-GABA Receptors, Benzodiazepine GABA Receptors, Muscimol Benzodiazepine-GABA Receptor Benzodiazepine GABA Receptor Receptor, Benzodiazepine-GABA GABA-Benzodiazepine Receptor GABA Benzodiazepine Receptor Receptor, GABA-Benzodiazepine GABA-Benzodiazepine Receptors GABA Benzodiazepine Receptors Benzodiazepine-Gaba Receptors Benzodiazepine Gaba Receptors Receptors, GABA-Benzodiazepine Receptors, GABA Benzodiazepine GABA(A) Receptor Muscimol Receptors GABA-A Receptor alpha Subunit GABA-A Receptor alpha Subunit GABA A Receptor alpha Subunit GABA-A Receptor rho Subunit GABA-A Receptor rho Subunit GABA A Receptor rho Subunit GABA-A Receptor delta Subunit GABA-A Receptor delta Subunit GABA A Receptor delta Subunit delta Subunit, GABA-A Receptor delta Subunit, GABA A Receptor GABA-A Receptor epsilon Subunit GABA-A Receptor epsilon Subunit GABA A Receptor epsilon Subunit epsilon Subunit, GABA-A Receptor epsilon Subunit, GABA A Receptor GABA-A Receptor gamma Subunit GABA-A Receptor gamma Subunit GABA A Receptor gamma Subunit Benzodiazepine Receptor Benzodiazepine Receptor Receptor, Benzodiazepine Receptors, Diazepam Diazepam Receptor Receptor, Diazepam Diazepam Receptors Benzodiazepine Receptors Receptors, Benzodiazepine GABA-A Receptor beta Subunit GABA-A Receptor beta Subunit GABA A Receptor beta Subunit

Below are MeSH descriptors whose meaning is more general than "Receptors, GABA-A".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Membrane Transport Proteins [D12.776.157.530]
Ion Channels [D12.776.157.530.400]
Chloride Channels [D12.776.157.530.400.175]
Receptors, GABA-A [D12.776.157.530.400.175.562]
Ligand-Gated Ion Channels [D12.776.157.530.400.400]
Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.157.530.400.400.100]
Receptors, GABA-A [D12.776.157.530.400.400.100.100]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Ion Channels [D12.776.543.550.450]
Chloride Channels [D12.776.543.550.450.175]
Receptors, GABA-A [D12.776.543.550.450.175.562]
Ligand-Gated Ion Channels [D12.776.543.550.450.500]
Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.550.450.500.100]
Receptors, GABA-A [D12.776.543.550.450.500.100.100]
Membrane Transport Proteins [D12.776.543.585]
Ion Channels [D12.776.543.585.400]
Chloride Channels [D12.776.543.585.400.175]
Receptors, GABA-A [D12.776.543.585.400.175.562]
Ligand-Gated Ion Channels [D12.776.543.585.400.500]
Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.585.400.500.100]
Receptors, GABA-A [D12.776.543.585.400.500.100.100]
Receptors, Cell Surface [D12.776.543.750]
Cysteine Loop Ligand-Gated Ion Channel Receptors [D12.776.543.750.130]
Receptors, GABA-A [D12.776.543.750.130.500]
Receptors, Neurotransmitter [D12.776.543.750.720]
Receptors, Amino Acid [D12.776.543.750.720.200]
Receptors, GABA [D12.776.543.750.720.200.300]
Receptors, GABA-A [D12.776.543.750.720.200.300.300]

Below are MeSH descriptors whose meaning is related to "Receptors, GABA-A".

Below are MeSH descriptors whose meaning is more specific than "Receptors, GABA-A".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Receptors, GABA-A" by people in this website by year, and whether "Receptors, GABA-A" was a major or minor topic of these publications.

Bar chart showing 58 publications over 23 distinct years, with a maximum of 5 publications in 2007 and 2011

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	3	4
1998	1	0	1
1999	1	0	1
2001	1	1	2
2002	3	0	3
2003	1	1	2
2004	3	1	4
2005	0	1	1
2006	1	3	4
2007	5	0	5
2008	1	1	2
2009	1	2	3
2010	0	2	2
2011	5	0	5
2012	2	0	2
2013	3	1	4
2014	2	0	2
2015	2	0	2
2016	2	2	4
2017	1	0	1
2018	1	0	1
2019	2	0	2
2021	1	0	1

Below are the most recent publications written about "Receptors, GABA-A" by people in Profiles.

Cadeddu R, Knutson DE, Mosher LJ, Loizou S, Odeh K, Fisher JL, Cook JM, Bortolato M. The a6 GABAA Receptor Positive Allosteric Modulator DK-I-56-1 Reduces Tic-Related Behaviors in Mouse Models of Tourette Syndrome. Biomolecules. 2021 01 28; 11(2).

View in: PubMed
Sansalone L, Bratsch-Prince J, Tang S, Captain B, Mott DD, Raymo FM. Photopotentiation of the GABAA receptor with caged diazepam. Proc Natl Acad Sci U S A. 2019 10 15; 116(42):21176-21184.

View in: PubMed
Robinson LC, Barat O, Mellott JG. GABAergic and glutamatergic cells in the inferior colliculus dynamically express the GABAAR ?1 subunit during aging. Neurobiol Aging. 2019 08; 80:99-110.

View in: PubMed
Forkuo GS, Nieman AN, Kodali R, Zahn NM, Li G, Rashid Roni MS, Stephen MR, Harris TW, Jahan R, Guthrie ML, Yu OB, Fisher JL, Yocum GT, Emala CW, Steeber DA, Stafford DC, Cook JM, Arnold LA. A Novel Orally Available Asthma Drug Candidate That Reduces Smooth Muscle Constriction and Inflammation by Targeting GABAA Receptors in the Lung. Mol Pharm. 2018 05 07; 15(5):1766-1777.

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Lewter LA, Fisher JL, Siemian JN, Methuku KR, Poe MM, Cook JM, Li JX. Antinociceptive Effects of a Novel a2/a3-Subtype Selective GABAA Receptor Positive Allosteric Modulator. ACS Chem Neurosci. 2017 06 21; 8(6):1305-1312.

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Azarashvili T, Krestinina O, Baburina Y, Odinokova I, Akatov V, Beletsky I, Lemasters J, Papadopoulos V. Effect of the CRAC Peptide, VLNYYVW, on mPTP Opening in Rat Brain and Liver Mitochondria. Int J Mol Sci. 2016 Dec 13; 17(12).

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Kong X, Luo S, Wu JR, Wu S, De Cecco CN, Schoepf UJ, Spandorfer AJ, Wang CY, Tian Y, Chen HJ, Lu GM, Yang GF, Zhang LJ. (18)F-DPA-714 PET Imaging for Detecting Neuroinflammation in Rats with Chronic Hepatic Encephalopathy. Theranostics. 2016; 6(8):1220-31.

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Boyd SJ, Schacht JP, Prisciandaro JJ, Voronin K, Anton RF. Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals. Alcohol Alcohol. 2016 Sep; 51(5):549-54.

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Centanni SW, Burnett EJ, Trantham-Davidson H, Chandler LJ. Loss of d-GABAA receptor-mediated tonic currents in the adult prelimbic cortex following adolescent alcohol exposure. Addict Biol. 2017 May; 22(3):616-628.

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Azarashvili T, Krestinina O, Baburina Y, Odinokova I, Grachev D, Papadopoulos V, Akatov V, Lemasters JJ, Reiser G. Combined effect of G3139 and TSPO ligands on Ca(2+)-induced permeability transition in rat brain mitochondria. Arch Biochem Biophys. 2015 Dec 01; 587:70-7.

View in: PubMed

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