"Cocaine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.
| Descriptor ID |
D003042
|
| MeSH Number(s) |
D02.145.074.722.388 D03.132.889.354 D03.605.084.500.722.388 D03.605.869.388
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Cocaine".
Below are MeSH descriptors whose meaning is more specific than "Cocaine".
This graph shows the total number of publications written about "Cocaine" by people in this website by year, and whether "Cocaine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 8 | 3 | 11 |
| 1995 | 13 | 3 | 16 |
| 1996 | 12 | 1 | 13 |
| 1997 | 10 | 1 | 11 |
| 1998 | 7 | 2 | 9 |
| 1999 | 7 | 2 | 9 |
| 2000 | 3 | 2 | 5 |
| 2001 | 5 | 0 | 5 |
| 2002 | 4 | 0 | 4 |
| 2003 | 11 | 4 | 15 |
| 2004 | 3 | 4 | 7 |
| 2005 | 9 | 4 | 13 |
| 2006 | 14 | 2 | 16 |
| 2007 | 11 | 5 | 16 |
| 2008 | 16 | 3 | 19 |
| 2009 | 8 | 4 | 12 |
| 2010 | 13 | 2 | 15 |
| 2011 | 12 | 4 | 16 |
| 2012 | 11 | 2 | 13 |
| 2013 | 16 | 8 | 24 |
| 2014 | 13 | 4 | 17 |
| 2015 | 5 | 4 | 9 |
| 2016 | 7 | 1 | 8 |
| 2017 | 14 | 8 | 22 |
| 2018 | 10 | 2 | 12 |
| 2019 | 9 | 4 | 13 |
| 2020 | 5 | 0 | 5 |
| 2021 | 4 | 1 | 5 |
| 2022 | 4 | 0 | 4 |
| 2023 | 3 | 0 | 3 |
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Below are the most recent publications written about "Cocaine" by people in Profiles.
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A review on the role of metabotropic glutamate receptors in neuroplasticity following psychostimulant use disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2023 Jun 08; 124:110735.
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Epigenetic function during heroin self-administration controls future relapse-associated behavior in a cell type-specific manner. Proc Natl Acad Sci U S A. 2023 02 14; 120(7):e2210953120.
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Self-report and urine drug screen concordance among women with co-occurring PTSD and substance use disorders participating in a clinical trial: Impact of drug type and participant characteristics. Drug Alcohol Depend. 2023 03 01; 244:109769.
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Interpersonal Violence, PTSD, and Substance Use Types among Women Receiving Substance Use Treatment. J Dual Diagn. 2022 Jul-Sep; 18(3):123-134.
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Sex and drug differences in stress, craving and cortisol response to the trier social stress task. Psychopharmacology (Berl). 2022 Sep; 239(9):2819-2827.
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Drug versus non-drug behaviors: A dual-reward model of sex differences and neurobiological mechanisms in rats. J Exp Anal Behav. 2022 05; 117(3):457-471.
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Linking drug and food addiction via compulsive appetite. Br J Pharmacol. 2022 06; 179(11):2589-2609.
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The impact of marijuana use on cocaine use outcomes among patients in methadone maintenance treatment across five trials of contingency management. Psychol Addict Behav. 2022 Aug; 36(5):526-536.
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Accumbens D2-MSN hyperactivity drives antipsychotic-induced behavioral supersensitivity. Mol Psychiatry. 2021 11; 26(11):6159-6169.
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Synaptic Adaptations at the Rostromedial Tegmental Nucleus Underlie Individual Differences in Cocaine Avoidance Behavior. J Neurosci. 2021 05 26; 41(21):4620-4630.