Phosphatidylinositol 3-Kinases

"Phosphatidylinositol 3-Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.

Descriptor ID	D019869
MeSH Number(s)	D08.811.913.696.620.500
Concept/Terms	Phosphatidylinositol 3-Kinases Phosphatidylinositol 3-Kinases Phosphatidylinositol 3 Kinases Phosphoinositide 3-Hydroxykinase PI 3-Kinase PtdIns 3-Kinases 3-Kinases, PtdIns PtdIns 3 Kinases PI-3K PI3 Kinases Kinases, PI3 PI3-Kinase PtdIns 3-Kinase Phosphatidylinositol-3-OH Kinase PI-3 Kinase

Below are MeSH descriptors whose meaning is more general than "Phosphatidylinositol 3-Kinases".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Phosphatidylinositol 3-Kinases [D08.811.913.696.620.500]

Below are MeSH descriptors whose meaning is related to "Phosphatidylinositol 3-Kinases".

Below are MeSH descriptors whose meaning is more specific than "Phosphatidylinositol 3-Kinases".

Phosphatidylinositol 3-Kinases
Phosphatidylinositol 3-Kinase
Phosphatidylinositol-4-Phosphate 3-Kinase

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Phosphatidylinositol 3-Kinases" by people in this website by year, and whether "Phosphatidylinositol 3-Kinases" was a major or minor topic of these publications.

Bar chart showing 146 publications over 27 distinct years, with a maximum of 11 publications in 2003 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	3	3
1996	0	2	2
1997	0	1	1
1998	0	2	2
1999	1	2	3
2000	2	5	7
2001	2	2	4
2002	2	4	6
2003	4	7	11
2004	2	4	6
2005	5	5	10
2006	2	6	8
2007	5	4	9
2008	3	5	8
2009	2	2	4
2010	1	1	2
2011	0	3	3
2012	1	8	9
2013	2	5	7
2014	2	6	8
2015	4	7	11
2016	0	1	1
2017	0	3	3
2018	1	4	5
2019	1	5	6
2020	1	3	4
2022	1	2	3

Below are the most recent publications written about "Phosphatidylinositol 3-Kinases" by people in Profiles.

Erben L, Welday JP, Cronin ME, Murphy R, Skirzewski M, Vullhorst D, Carroll SL, Buonanno A. Developmental, neurochemical, and behavioral analyses of ErbB4 Cyt-1 knockout mice. J Neurochem. 2022 06; 161(5):435-452.

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Wei J, Zhang J, Wang D, Cen B, Lang JD, DuBois RN. The COX-2-PGE2 Pathway Promotes Tumor Evasion in Colorectal Adenomas. Cancer Prev Res (Phila). 2022 05 03; 15(5):285-296.

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Nowling TK. Mesangial Cells in Lupus Nephritis. Curr Rheumatol Rep. 2022 01 05; 23(12):83.

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Li Y, Sun W, Saaoud F, Wang Y, Wang Q, Hodge J, Hui Y, Yin S, Lessner SM, Kong X, Fan D. MiR155 modulates vascular calcification by regulating Akt-FOXO3a signalling and apoptosis in vascular smooth muscle cells. J Cell Mol Med. 2021 01; 25(1):535-548.

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Das A, Alshareef M, Porto GBF, Infinger LK, Vandergrift WA, Lindhorst SM, Varma AK, Patel SJ, Cachia D. Preconditioning with INC280 and LDK378 drugs sensitizes MGMT-unmethylated glioblastoma to temozolomide: Pre-clinical assessment. J Neurol Sci. 2020 Nov 15; 418:117102.

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Das A, Henderson FC, Alshareef M, Porto GBF, Kanginakudru I, Infinger LK, Vandergrift WA, Lindhorst SM, Varma AK, Patel SJ, Cachia D. MGMT-inhibitor in combination with TGF-ßRI inhibitor or CDK 4/6 inhibitor increases temozolomide sensitivity in temozolomide-resistant glioblastoma cells. Clin Transl Oncol. 2021 Mar; 23(3):612-619.

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Das A, Martinez Santos JL, Alshareef M, Porto GBF, Infinger LK, Vandergrift WA, Lindhorst SM, Varma AK, Patel SJ, Cachia D. In Vitro Effect of Dovitinib (TKI258), a Multi-Target Angiokinase Inhibitor on Aggressive Meningioma Cells. Cancer Invest. 2020 Jul; 38(6):349-355.

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Das A, Alshareef M, Henderson F, Martinez Santos JL, Vandergrift WA, Lindhorst SM, Varma AK, Infinger L, Patel SJ, Cachia D. Ganoderic acid A/DM-induced NDRG2 over-expression suppresses high-grade meningioma growth. Clin Transl Oncol. 2020 Jul; 22(7):1138-1145.

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da Silveira WA, Vazquez-Hidalgo E, Bartolotta E, Renaud L, Paolini P, Hardiman G. The effects of rosiglitazone on the neonatal rat cardiomyocyte transcriptome: a temporal analysis. Pharmacogenomics. 2019 11; 20(16):1125-1141.

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Sun B, Mason S, Wilson RC, Hazard SE, Wang Y, Fang R, Wang Q, Yeh ES, Yang M, Roberts TM, Zhao JJ, Wang Q. Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers. Oncogene. 2020 01; 39(1):50-63.

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