Fibroblast Growth Factor 2
"Fibroblast Growth Factor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
| Descriptor ID |
D016222
|
| MeSH Number(s) |
D12.644.276.624.120 D12.776.467.624.120 D23.529.624.120
|
| Concept/Terms |
Fibroblast Growth Factor 2- Fibroblast Growth Factor 2
- Basic Fibroblast Growth Factor
- Class II Heparin-Binding Growth Factor
- Heparin-Binding Growth Factor Class II
- HBGF-2
- Prostatropin
- FGF-2
- FGF 2
- FGF2
- Fibroblast Growth Factor, Basic
- Fibroblast Growth Factor-2
- Cartilage-Derived Growth Factor
- Cartilage Derived Growth Factor
- Prostate Epithelial Cell Growth Factor
|
Below are MeSH descriptors whose meaning is more general than "Fibroblast Growth Factor 2".
Below are MeSH descriptors whose meaning is more specific than "Fibroblast Growth Factor 2".
This graph shows the total number of publications written about "Fibroblast Growth Factor 2" by people in this website by year, and whether "Fibroblast Growth Factor 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 2 | 3 |
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 4 | 4 |
| 2004 | 2 | 3 | 5 |
| 2005 | 1 | 1 | 2 |
| 2006 | 1 | 2 | 3 |
| 2007 | 1 | 3 | 4 |
| 2008 | 0 | 1 | 1 |
| 2009 | 2 | 0 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2015 | 2 | 0 | 2 |
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Fibroblast Growth Factor 2" by people in Profiles.
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Olfactory cleft mucus proteins associated with olfactory dysfunction in a cohort without chronic rhinosinusitis. Int Forum Allergy Rhinol. 2019 10; 9(10):1151-1158.
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A biochemical basis for induction of retina regeneration by antioxidants. Dev Biol. 2018 01 15; 433(2):394-403.
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FGF2 mediates hepatic progenitor cell formation during human pluripotent stem cell differentiation by inducing the WNT antagonist NKD1. Genes Dev. 2015 Dec 01; 29(23):2463-74.
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Vitamin D3 as a novel regulator of basic fibroblast growth factor in chronic rhinosinusitis with nasal polyposis. Int Forum Allergy Rhinol. 2015 Mar; 5(3):191-6.
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SOCS-1/3 participation in FGF-2 signaling to modulate RANK ligand expression in paget's disease of bone. J Cell Biochem. 2013 Sep; 114(9):2032-8.
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Proteoglycan 4: a dynamic regulator of skeletogenesis and parathyroid hormone skeletal anabolism. J Bone Miner Res. 2012 Jan; 27(1):11-25.
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The regulatory function of SPARC in vascular biology. Cell Mol Life Sci. 2011 Oct; 68(19):3165-73.
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FGF-2 stimulation of RANK ligand expression in Paget's disease of bone. Mol Endocrinol. 2009 Sep; 23(9):1445-54.
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In vivo vascular tissue engineering: influence of cytokine and implant location on tissue specific cellular recruitment. J Tissue Eng Regen Med. 2009 Jun; 3(4):280-9.
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DACH1 negatively regulates the human RANK ligand gene expression in stromal/preosteoblast cells. J Cell Biochem. 2008 Apr 15; 103(6):1747-59.