Fibroblast Growth Factor 1
"Fibroblast Growth Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).
| Descriptor ID |
D016220
|
| MeSH Number(s) |
D12.644.276.624.110 D12.776.467.624.110 D23.529.624.110
|
| Concept/Terms |
Fibroblast Growth Factor 1- Fibroblast Growth Factor 1
- HBGF-1
- Heparin-Binding Fibroblast Growth Factor Class I
- Heparin-Binding Growth Factor, Class I
- Heparin Binding Growth Factor, Class I
- Fibroblast Growth Factor, Acidic
- Fibroblast Growth Factor-1
- Class I Heparin-Binding Growth Factor
- FGF-1
- FGF1
- Acidic Fibroblast Growth Factor
|
Below are MeSH descriptors whose meaning is more general than "Fibroblast Growth Factor 1".
Below are MeSH descriptors whose meaning is more specific than "Fibroblast Growth Factor 1".
This graph shows the total number of publications written about "Fibroblast Growth Factor 1" by people in this website by year, and whether "Fibroblast Growth Factor 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 2 | 1 | 3 |
| 2006 | 1 | 1 | 2 |
| 2011 | 1 | 0 | 1 |
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Below are the most recent publications written about "Fibroblast Growth Factor 1" by people in Profiles.
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Plasticity in interactions of fibroblast growth factor 1 (FGF1) N terminus with FGF receptors underlies promiscuity of FGF1. J Biol Chem. 2012 Jan 27; 287(5):3067-78.
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Transcription factor Ets-1 regulates fibroblast growth factor-1-mediated angiogenesis in vivo: role of Ets-1 in the regulation of the PI3K/AKT/MMP-1 pathway. J Vasc Res. 2006; 43(4):327-37.
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Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis. J Neurochem. 2006 May; 97(3):687-96.
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Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: consequences for motor neuron survival. J Biol Chem. 2005 Jul 08; 280(27):25571-9.
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Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis. J Neurochem. 2005 Apr; 93(1):38-46.
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Complexity of astrocyte-motor neuron interactions in amyotrophic lateral sclerosis. Neurodegener Dis. 2005; 2(3-4):139-46.
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Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):935-40.
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Selection of peptide ligands binding to fibroblast growth factor receptor 1. IUBMB Life. 2002 Aug; 54(2):67-72.
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Characterization of fibroblast growth factor receptor 2 overexpression in the human breast cancer cell line SUM-52PE. Breast Cancer Res. 2000; 2(4):311-20.