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Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression.

Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression. Cancer Res. 2017 12 15; 77(24):6950-6962.

View in: PubMed

subject areas
  • Acyltransferases
  • Amino Acid Substitution
  • Animals
  • Cells, Cultured
  • Disease Progression
  • Enzyme Inhibitors
  • HEK293 Cells
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, SCID
  • Mutation, Missense
  • Myristic Acid
  • Phosphorylation
  • Phosphotransferases
  • Prostatic Neoplasms
  • Protein Processing, Post-Translational
  • Proto-Oncogene Proteins pp60(c-src)
  • Structure-Activity Relationship
  • Tumor Suppressor Proteins

authors with profiles
  • Aiping Bai
  • Zdzislaw Szulc
  • James S. Norris