"Enzyme Inhibitors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Descriptor ID |
D004791
|
MeSH Number(s) |
D27.505.519.389
|
Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Enzyme Inhibitors".
Below are MeSH descriptors whose meaning is more specific than "Enzyme Inhibitors".
This graph shows the total number of publications written about "Enzyme Inhibitors" by people in this website by year, and whether "Enzyme Inhibitors" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1994 | 0 | 1 | 1 |
1995 | 2 | 1 | 3 |
1996 | 11 | 11 | 22 |
1997 | 5 | 13 | 18 |
1998 | 6 | 17 | 23 |
1999 | 8 | 16 | 24 |
2000 | 6 | 15 | 21 |
2001 | 7 | 10 | 17 |
2002 | 8 | 10 | 18 |
2003 | 10 | 33 | 43 |
2004 | 9 | 31 | 40 |
2005 | 7 | 19 | 26 |
2006 | 9 | 21 | 30 |
2007 | 8 | 14 | 22 |
2008 | 10 | 9 | 19 |
2009 | 6 | 14 | 20 |
2010 | 8 | 9 | 17 |
2011 | 5 | 9 | 14 |
2012 | 6 | 10 | 16 |
2013 | 3 | 14 | 17 |
2014 | 5 | 7 | 12 |
2015 | 4 | 3 | 7 |
2016 | 8 | 6 | 14 |
2017 | 3 | 5 | 8 |
2018 | 8 | 6 | 14 |
2019 | 4 | 2 | 6 |
2020 | 3 | 1 | 4 |
2021 | 3 | 4 | 7 |
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Below are the most recent publications written about "Enzyme Inhibitors" by people in Profiles.
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Discovery and Optimization of Pyrazole Amides as Inhibitors of ELOVL1. J Med Chem. 2021 12 23; 64(24):17753-17776.
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Forrestiacids A and B, Pentaterpene Inhibitors of ACL and Lipogenesis: Extending the Limits of Computational NMR Methods in the Structure Assignment of Complex Natural Products. Angew Chem Int Ed Engl. 2021 10 04; 60(41):22270-22275.
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Characterization of endothelium-dependent and -independent processes in occipital artery of the rat: relevance to control of blood flow to nodose sensory cells. J Appl Physiol (1985). 2021 09 01; 131(3):1067-1079.
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The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer. Breast Cancer Res. 2021 06 12; 23(1):65.
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Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis. N Engl J Med. 2021 02 11; 384(6):512-520.
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GSNOR and ALDH2 alleviate traumatic spinal cord injury. Brain Res. 2021 05 01; 1758:147335.
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Ceramide synthase 2-C24:1 -ceramide axis limits the metastatic potential of ovarian cancer cells. FASEB J. 2021 02; 35(2):e21287.
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Mechanistic insights into ceramidase inhibitor LCL521-enhanced tumor cell killing by photodynamic and thermal ablation therapies. Photochem Photobiol Sci. 2020 Sep 09; 19(9):1145-1151.
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Higher intestinal and circulatory lactate associated NOX2 activation leads to an ectopic fibrotic pathology following microcystin co-exposure in murine fatty liver disease. Comp Biochem Physiol C Toxicol Pharmacol. 2020 Dec; 238:108854.
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Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening. SLAS Discov. 2021 01; 26(1):113-121.