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Anti-CTLA-4 Activates Intratumoral NK Cells and Combined with IL15/IL15Ra Complexes Enhances Tumor Control.

Anti-CTLA-4 Activates Intratumoral NK Cells and Combined with IL15/IL15Ra Complexes Enhances Tumor Control. Cancer Immunol Res. 2019 08; 7(8):1371-1380.

View in: PubMed

subject areas
  • Animals
  • Antineoplastic Agents, Immunological
  • Carcinoma, Non-Small-Cell Lung
  • Cell Degranulation
  • CTLA-4 Antigen
  • Disease Models, Animal
  • Gene Expression
  • Humans
  • Interleukin-15
  • Interleukin-15 Receptor alpha Subunit
  • Ipilimumab
  • Killer Cells, Natural
  • Lymphocyte Activation
  • Lymphocytes, Tumor-Infiltrating
  • Mice
  • Neoplasms
  • T-Lymphocytes, Regulatory
  • Tumor Microenvironment
  • Xenograft Model Antitumor Assays

authors with profiles
  • Jeffrey E. Hammerbacher
  • Mark P Rubinstein
  • Bulent Aksoy