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    • ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis.
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ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis.

ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis. J Biol Chem. 2008 Sep 05; 283(36):25003-13.

View in: PubMed

subject areas
  • Antineoplastic Agents
  • Apoptosis
  • Biphenyl Compounds
  • CASP8 and FADD-Like Apoptosis Regulating Protein
  • Caspase 8
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Fas-Associated Death Domain Protein
  • Humans
  • Mutagenesis
  • Myeloid Cell Leukemia Sequence 1 Protein
  • Neoplasms
  • NF-kappa B
  • Nitrophenols
  • Piperazines
  • Proto-Oncogene Proteins c-bcl-2
  • Receptors, TNF-Related Apoptosis-Inducing Ligand
  • Response Elements
  • Sulfonamides
  • TNF-Related Apoptosis-Inducing Ligand
  • Up-Regulation

authors with profiles
  • Andrew S Kraft