"Up-Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
| Descriptor ID |
D015854
|
| MeSH Number(s) |
G02.111.905 G05.308.850 G07.690.773.998
|
| Concept/Terms |
Up-Regulation- Up-Regulation
- Up Regulation
- Upregulation
- Up-Regulation (Physiology)
|
Below are MeSH descriptors whose meaning is more general than "Up-Regulation".
Below are MeSH descriptors whose meaning is more specific than "Up-Regulation".
This graph shows the total number of publications written about "Up-Regulation" by people in this website by year, and whether "Up-Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 5 | 6 |
| 1995 | 1 | 1 | 2 |
| 1996 | 0 | 5 | 5 |
| 1997 | 1 | 4 | 5 |
| 1998 | 0 | 5 | 5 |
| 1999 | 1 | 2 | 3 |
| 2000 | 2 | 6 | 8 |
| 2001 | 2 | 6 | 8 |
| 2002 | 3 | 6 | 9 |
| 2003 | 3 | 13 | 16 |
| 2004 | 5 | 19 | 24 |
| 2005 | 2 | 24 | 26 |
| 2006 | 3 | 23 | 26 |
| 2007 | 1 | 20 | 21 |
| 2008 | 3 | 31 | 34 |
| 2009 | 3 | 22 | 25 |
| 2010 | 9 | 25 | 34 |
| 2011 | 1 | 26 | 27 |
| 2012 | 2 | 29 | 31 |
| 2013 | 3 | 25 | 28 |
| 2014 | 2 | 14 | 16 |
| 2015 | 7 | 16 | 23 |
| 2016 | 1 | 18 | 19 |
| 2017 | 6 | 15 | 21 |
| 2018 | 1 | 13 | 14 |
| 2019 | 0 | 9 | 9 |
| 2020 | 0 | 9 | 9 |
| 2021 | 0 | 3 | 3 |
| 2022 | 1 | 2 | 3 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Up-Regulation" by people in Profiles.
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Upregulation of sphingosine kinase 1 in response to doxorubicin generates an angiogenic response via stabilization of Snail. FASEB J. 2023 03; 37(3):e22787.
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Upregulation of the EGFR/MEK1/MAPK1/2 signaling axis as a mechanism of resistance to antiestrogen-induced BimEL dependent apoptosis in ER+ breast cancer cells. Int J Oncol. 2023 Feb; 62(2).
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Chitooligosaccharide prevents vascular endothelial cell apoptosis by attenuation of endoplasmic reticulum stress via suppression of oxidative stress through Nrf2-SOD1 up-regulation. Pharm Biol. 2022 Dec; 60(1):2155-2166.
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Up-Regulated Interleukin-10 Induced by E2F Transcription Factor 2-MicroRNA-17-5p Circuitry in Extrafollicular Effector B Cells Contributes to Autoantibody Production in Systemic Lupus Erythematosus. Arthritis Rheumatol. 2022 03; 74(3):496-507.
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Astrocytes in the ventral pallidum extinguish heroin seeking through GAT-3 upregulation and morphological plasticity at D1-MSN terminals. Mol Psychiatry. 2022 02; 27(2):855-864.
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Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions. J Neuroinflammation. 2021 Sep 22; 18(1):219.
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Exercise training and diet-induced weight loss increase markers of hepatic bile acid (BA) synthesis and reduce serum total BA concentrations in obese women. Am J Physiol Endocrinol Metab. 2021 05 01; 320(5):E864-E873.
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GPR40 deficiency is associated with hepatic FAT/CD36 upregulation, steatosis, inflammation, and cell injury in C57BL/6 mice. Am J Physiol Endocrinol Metab. 2021 01 01; 320(1):E30-E42.
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High-Mobility Group Box-1 Is Associated With Obesity, Inflammation, and Subclinical Cardiovascular Risk Among Young Adults: A Longitudinal Cohort Study. Arterioscler Thromb Vasc Biol. 2020 11; 40(11):2776-2784.
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PIM Kinase Inhibitors Block the Growth of Primary T-cell Acute Lymphoblastic Leukemia: Resistance Pathways Identified by Network Modeling Analysis. Mol Cancer Ther. 2020 09; 19(9):1809-1821.