Immunoglobulin Joining Region
"Immunoglobulin Joining Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A segment of the immunoglobulin heavy chains, encoded by the IMMUNOGLOBULIN HEAVY CHAIN GENES in the J segment where, during the maturation of B-LYMPHOCYTES; the gene segment for the variable region upstream is joined to a constant region gene segment downstream. The exact position of joining of the two gene segments is variable and contributes to ANTIBODY DIVERSITY. It is distinguished from the IMMUNOGLOBULIN J CHAINS; a separate polypeptide that serves as a linkage piece in polymeric IGA or IGM.
Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Joining Region".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Joining Region".
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Below are the most recent publications written about "Immunoglobulin Joining Region" by people in Profiles.
Structure of the catfish IGH locus: analysis of the region including the single functional IGHM gene. Immunogenetics. 2006 Oct; 58(10):831-44.
Differences in idiopathic inflammatory myopathy phenotypes and genotypes between Mesoamerican Mestizos and North American Caucasians: ethnogeographic influences in the genetics and clinical expression of myositis. Arthritis Rheum. 2002 Jul; 46(7):1885-93.
Identification of MART-1-specific T-cell receptors: T cells utilizing distinct T-cell receptor variable and joining regions recognize the same tumor epitope. Cancer Res. 1994 Oct 15; 54(20):5265-8.