"Single-Chain Antibodies" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A form of antibodies consisting only of the variable regions of the heavy and light chains (FV FRAGMENTS), connected by a small linker peptide. They are less immunogenic than complete immunoglobulin and thus have potential therapeutic use.
| Descriptor ID |
D057127
|
| MeSH Number(s) |
D12.644.541.500.650.500.800 D12.776.124.486.485.114.224.785 D12.776.124.486.485.680.650.500.800 D12.776.124.790.651.680.650.500.800 D12.776.377.715.548.680.650.500.795
|
| Concept/Terms |
Single-Chain Antibodies- Single-Chain Antibodies
- Antibodies, Single-Chain
- Single Chain Antibodies
- ScFv Antibodies
- Antibodies, ScFv
- Single-Chain Fv
- Fv, Single-Chain
- Single Chain Fv
- Single-Chain Fv Antibody
- Antibody, Single-Chain Fv
- Fv Antibody, Single-Chain
- Single Chain Fv Antibody
- Single-Chain Variable Fragment
- Fragment, Single-Chain Variable
- Single Chain Variable Fragment
- Variable Fragment, Single-Chain
- Single-Chain Variable Fragment Antibodies
- Single Chain Variable Fragment Antibodies
- Single-Chain Variable Fragment Antibody
- Single Chain Variable Fragment Antibody
- Single-Chain Variable Fragments
- Fragments, Single-Chain Variable
- Single Chain Variable Fragments
- Variable Fragments, Single-Chain
- Fv Antibody Fragments, Single-Chain
- Fv Antibody Fragments, Single Chain
- Single-Chain Fv Antibody Fragments
- Single Chain Fv Antibody Fragments
|
Below are MeSH descriptors whose meaning is more general than "Single-Chain Antibodies".
Below are MeSH descriptors whose meaning is more specific than "Single-Chain Antibodies".
This graph shows the total number of publications written about "Single-Chain Antibodies" by people in this website by year, and whether "Single-Chain Antibodies" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 1 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Single-Chain Antibodies" by people in Profiles.
-
Characterization of Novel P-Selectin Targeted Complement Inhibitors in Murine Models of Hindlimb Injury and Transplantation. Front Immunol. 2021; 12:785229.
-
Increasing the efficacy and safety of a human complement inhibitor for treating post-transplant cardiac ischemia reperfusion injury by targeting to a graft-specific neoepitope. J Heart Lung Transplant. 2021 10; 40(10):1112-1121.
-
C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice. Front Immunol. 2020; 11:575154.
-
Novel TCR-based biologics: mobilising T cells to warm 'cold' tumours. Cancer Treat Rev. 2019 Jul; 77:35-43.
-
Targeting pathogenic postischemic self-recognition by natural IgM to protect against posttransplantation cardiac reperfusion injury. Circulation. 2015 Mar 31; 131(13):1171-80.
-
Transferrin receptor targeting nanomedicine delivering wild-type p53 gene sensitizes pancreatic cancer to gemcitabine therapy. Cancer Gene Ther. 2013 Apr; 20(4):222-8.