"Glutaredoxins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of thioltransferases that contain two active site CYSTEINE residues, which either form a disulfide (oxidized form) or a dithiol (reduced form). They function as an electron carrier in the GLUTHIONE-dependent synthesis of deoxyribonucleotides by RIBONUCLEOTIDE REDUCTASES and may play a role in the deglutathionylation of protein thiols. The oxidized forms of glutaredoxins are directly reduced by the GLUTATHIONE.
| Descriptor ID |
D054477
|
| MeSH Number(s) |
D08.811.682.667.084
|
| Concept/Terms |
Glutaredoxin 1- Glutaredoxin 1
- TTase-1
- TTase 1
- Thioltransferase-1
- Thioltransferase 1
|
Below are MeSH descriptors whose meaning is more general than "Glutaredoxins".
Below are MeSH descriptors whose meaning is more specific than "Glutaredoxins".
This graph shows the total number of publications written about "Glutaredoxins" by people in this website by year, and whether "Glutaredoxins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 1 | 1 | 2 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glutaredoxins" by people in Profiles.
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Glutathione S-transferase pi modulates NF-?B activation and pro-inflammatory responses in lung epithelial cells. Redox Biol. 2016 08; 8:375-82.
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A comparison of reversible versus irreversible protein glutathionylation. Adv Cancer Res. 2014; 122:177-98.
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Aging-dependent changes in rat heart mitochondrial glutaredoxins--Implications for redox regulation. Redox Biol. 2013; 1:586-98.
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Causes and consequences of cysteine S-glutathionylation. J Biol Chem. 2013 Sep 13; 288(37):26497-504.
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Glutaredoxin regulates apoptosis in cardiomyocytes via NFkappaB targets Bcl-2 and Bcl-xL: implications for cardiac aging. Antioxid Redox Signal. 2010 Jun 15; 12(12):1339-53.
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Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFkappaB. J Biol Chem. 2007 Jun 22; 282(25):18427-18436.