Hepatocyte Nuclear Factor 4
"Hepatocyte Nuclear Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A subfamily of nuclear receptors that regulate GENETIC TRANSCRIPTION of a diverse group of GENES involved in the synthesis of BLOOD COAGULATION FACTORS; and in GLUCOSE; CHOLESTEROL; and FATTY ACIDS metabolism.
| Descriptor ID |
D051557
|
| MeSH Number(s) |
D12.776.260.262.968 D12.776.660.352.968 D12.776.826.119 D12.776.930.318.968
|
| Concept/Terms |
Hepatocyte Nuclear Factor 4- Hepatocyte Nuclear Factor 4
- Hepatocyte Nuclear Factor-Forkhead Homolog 4
- Hepatocyte Nuclear Factor Forkhead Homolog 4
- HNF4 Transcription Factor
- Transcription Factor, HNF4
|
Below are MeSH descriptors whose meaning is more general than "Hepatocyte Nuclear Factor 4".
Below are MeSH descriptors whose meaning is more specific than "Hepatocyte Nuclear Factor 4".
This graph shows the total number of publications written about "Hepatocyte Nuclear Factor 4" by people in this website by year, and whether "Hepatocyte Nuclear Factor 4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1997 | 0 | 2 | 2 |
| 1998 | 0 | 2 | 2 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 3 | 3 |
| 2004 | 0 | 1 | 1 |
| 2005 | 0 | 3 | 3 |
| 2006 | 2 | 1 | 3 |
| 2007 | 2 | 0 | 2 |
| 2008 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hepatocyte Nuclear Factor 4" by people in Profiles.
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Role of hepatic PKC? in nutritional regulation of hepatic glycogen synthesis. JCI Insight. 2021 10 08; 6(19).
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A small-molecule screen reveals that HSP90? promotes the conversion of induced pluripotent stem cell-derived endoderm to a hepatic fate and regulates HNF4A turnover. Development. 2017 05 15; 144(10):1764-1774.
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Hepatocyte-like cells differentiated from human induced pluripotent stem cells: relevance to cellular therapies. Stem Cell Res. 2012 Nov; 9(3):196-207.
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HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells. Development. 2011 Oct; 138(19):4143-53.
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Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology. 2008 Oct; 48(4):1242-50.
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Cited2, a coactivator of HNF4alpha, is essential for liver development. EMBO J. 2007 Oct 31; 26(21):4445-56.
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P2 promoter variants of the hepatocyte nuclear factor 4alpha gene are associated with type 2 diabetes in Mexican Americans. Diabetes. 2007 Feb; 56(2):513-7.
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Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proc Natl Acad Sci U S A. 2006 May 30; 103(22):8419-24.
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Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter. J Lipid Res. 2006 Jul; 47(7):1463-77.
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Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Gastroenterology. 2006 Apr; 130(4):1207-20.