Hepatocyte Nuclear Factor 1
"Hepatocyte Nuclear Factor 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A transcription factor and homeodomain protein that regulates the expression of a large set of hepatic proteins including SERUM ALBUMIN; beta-fibrinogen; and ALPHA 1-ANTITRYPSIN. It is composed of hetero- or homo-dimers of HEPATOCYTE NUCLEAR FACTOR 1-ALPHA and HEPATOCYTE NUCLEAR FACTOR 1-BETA.
| Descriptor ID |
D051537
|
| MeSH Number(s) |
D12.776.260.262.500 D12.776.260.400.218 D12.776.660.352.500 D12.776.930.318.500
|
| Concept/Terms |
Hepatocyte Nuclear Factor 1- Hepatocyte Nuclear Factor 1
- Hepatic Nuclear Factor 1
- HNF-1 Protein
- HNF 1 Protein
- HNF1 Transcription Factor
- Transcription Factor, HNF1
|
Below are MeSH descriptors whose meaning is more general than "Hepatocyte Nuclear Factor 1".
Below are MeSH descriptors whose meaning is more specific than "Hepatocyte Nuclear Factor 1".
This graph shows the total number of publications written about "Hepatocyte Nuclear Factor 1" by people in this website by year, and whether "Hepatocyte Nuclear Factor 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hepatocyte Nuclear Factor 1" by people in Profiles.
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Insulin and epidermal growth factor suppress basal glucose-6-phosphatase catalytic subunit gene transcription through overlapping but distinct mechanisms. Biochem J. 2009 Jan 15; 417(2):611-20.
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Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors. Hepatology. 2004 Apr; 39(4):1038-47.
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Regulation of a transcription factor network required for differentiation and metabolism. Science. 1998 Jul 31; 281(5377):692-5.
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Mutation in the 4a-carbinolamine dehydratase gene leads to mild hyperphenylalaninemia with defective cofactor metabolism. Am J Hum Genet. 1993 Sep; 53(3):768-74.