Hepatocyte Nuclear Factor 4

"Hepatocyte Nuclear Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A subfamily of nuclear receptors that regulate GENETIC TRANSCRIPTION of a diverse group of GENES involved in the synthesis of BLOOD COAGULATION FACTORS; and in GLUCOSE; CHOLESTEROL; and FATTY ACIDS metabolism.

Descriptor ID	D051557
MeSH Number(s)	D12.776.260.262.968 D12.776.660.352.968 D12.776.826.119 D12.776.930.318.968
Concept/Terms	Hepatocyte Nuclear Factor 4 Hepatocyte Nuclear Factor 4 Hepatocyte Nuclear Factor-Forkhead Homolog 4 Hepatocyte Nuclear Factor Forkhead Homolog 4 HNF4 Transcription Factor Transcription Factor, HNF4 Hepatocyte Nuclear Factor 4-gamma Hepatocyte Nuclear Factor 4-gamma Hepatocyte Nuclear Factor 4 gamma Nuclear Receptor Subfamily 2 Group A, Member 2 Hepatocyte Nuclear Factor 4-alpha Hepatocyte Nuclear Factor 4-alpha Hepatocyte Nuclear Factor 4 alpha Nuclear Receptor Subfamily 2, Group A, Member 1 Hepatocyte Nuclear Factor 4-beta Hepatocyte Nuclear Factor 4-beta Hepatocyte Nuclear Factor 4 beta

Below are MeSH descriptors whose meaning is more general than "Hepatocyte Nuclear Factor 4".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Hepatocyte Nuclear Factors [D12.776.260.262]
Hepatocyte Nuclear Factor 4 [D12.776.260.262.968]
Nuclear Proteins [D12.776.660]
Hepatocyte Nuclear Factors [D12.776.660.352]
Hepatocyte Nuclear Factor 4 [D12.776.660.352.968]
Receptors, Cytoplasmic and Nuclear [D12.776.826]
Hepatocyte Nuclear Factor 4 [D12.776.826.119]
Transcription Factors [D12.776.930]
Hepatocyte Nuclear Factors [D12.776.930.318]
Hepatocyte Nuclear Factor 4 [D12.776.930.318.968]

Below are MeSH descriptors whose meaning is more specific than "Hepatocyte Nuclear Factor 4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Hepatocyte Nuclear Factor 4" by people in this website by year, and whether "Hepatocyte Nuclear Factor 4" was a major or minor topic of these publications.

Bar chart showing 26 publications over 16 distinct years, with a maximum of 3 publications in 2003 and 2005 and 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	2	2
1997	0	2	2
1998	0	2	2
2000	0	1	1
2001	0	1	1
2002	0	1	1
2003	0	3	3
2004	0	1	1
2005	0	3	3
2006	2	1	3
2007	2	0	2
2008	1	0	1
2011	1	0	1
2012	0	1	1
2017	1	0	1
2021	0	1	1

Below are the most recent publications written about "Hepatocyte Nuclear Factor 4" by people in Profiles.

Shu Y, Hassan F, Ostrowski MC, Mehta KD. Role of hepatic PKCß in nutritional regulation of hepatic glycogen synthesis. JCI Insight. 2021 10 08; 6(19).

View in: PubMed
Jing R, Duncan CB, Duncan SA. A small-molecule screen reveals that HSP90ß promotes the conversion of induced pluripotent stem cell-derived endoderm to a hepatic fate and regulates HNF4A turnover. Development. 2017 05 15; 144(10):1764-1774.

View in: PubMed
Yu Y, Liu H, Ikeda Y, Amiot BP, Rinaldo P, Duncan SA, Nyberg SL. Hepatocyte-like cells differentiated from human induced pluripotent stem cells: relevance to cellular therapies. Stem Cell Res. 2012 Nov; 9(3):196-207.

View in: PubMed
DeLaForest A, Nagaoka M, Si-Tayeb K, Noto FK, Konopka G, Battle MA, Duncan SA. HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells. Development. 2011 Oct; 138(19):4143-53.

View in: PubMed
Luebke-Wheeler J, Zhang K, Battle M, Si-Tayeb K, Garrison W, Chhinder S, Li J, Kaufman RJ, Duncan SA. Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology. 2008 Oct; 48(4):1242-50.

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Qu X, Lam E, Doughman YQ, Chen Y, Chou YT, Lam M, Turakhia M, Dunwoodie SL, Watanabe M, Xu B, Duncan SA, Yang YC. Cited2, a coactivator of HNF4alpha, is essential for liver development. EMBO J. 2007 Oct 31; 26(21):4445-56.

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Lehman DM, Richardson DK, Jenkinson CP, Hunt KJ, Dyer TD, Leach RJ, Arya R, Abboud HE, Blangero J, Duggirala R, Stern MP. P2 promoter variants of the hepatocyte nuclear factor 4alpha gene are associated with type 2 diabetes in Mexican Americans. Diabetes. 2007 Feb; 56(2):513-7.

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Battle MA, Konopka G, Parviz F, Gaggl AL, Yang C, Sladek FM, Duncan SA. Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. Proc Natl Acad Sci U S A. 2006 May 30; 103(22):8419-24.

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Rufibach LE, Duncan SA, Battle M, Deeb SS. Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter. J Lipid Res. 2006 Jul; 47(7):1463-77.

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Garrison WD, Battle MA, Yang C, Kaestner KH, Sladek FM, Duncan SA. Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Gastroenterology. 2006 Apr; 130(4):1207-20.

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