2',5'-Oligoadenylate Synthetase
"2',5'-Oligoadenylate Synthetase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of ATP into a series of (2'-5') linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.
| Descriptor ID |
D015088
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| MeSH Number(s) |
D08.811.913.696.445.625
|
| Concept/Terms |
2',5'-Oligoadenylate Synthetase- 2',5'-Oligoadenylate Synthetase
- 2',5' Oligoadenylate Synthetase
- Synthetase, 2',5'-Oligoadenylate
- 2,5 Oligoadenylate Polymerase
- Oligoadenylate Polymerase, 2,5
- Polymerase, 2,5 Oligoadenylate
- 2',5'-Oligoadenylate Polymerase
- 2',5' Oligoadenylate Polymerase
- Polymerase, 2',5'-Oligoadenylate
- (2'-5')An Polymerase
- ATP-(2'-5')oligo(A)adenylyltransferase
- 2',5'-Oligo(A) Synthetase
- 2',5'-Oligo(A) Polymerase
- 2,5 Oligoadenylate Synthetase
- Oligoadenylate Synthetase, 2,5
- Synthetase, 2,5 Oligoadenylate
- 2-5A Synthetase
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Below are MeSH descriptors whose meaning is more general than "2',5'-Oligoadenylate Synthetase".
Below are MeSH descriptors whose meaning is more specific than "2',5'-Oligoadenylate Synthetase".
This graph shows the total number of publications written about "2',5'-Oligoadenylate Synthetase" by people in this website by year, and whether "2',5'-Oligoadenylate Synthetase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "2',5'-Oligoadenylate Synthetase" by people in Profiles.
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Identification of interferon-inducible genes as diagnostic biomarker for systemic lupus erythematosus. Clin Rheumatol. 2015 Jan; 34(1):71-9.
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Interferon alpha enhances expression of TAG-72 and carcinoembryonic antigen in patients with primary colorectal cancer. Cancer Immunol Immunother. 1995 May; 40(5):311-4.
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Inhibition of interferon-gamma-induced major histocompatibility complex class II gene transcription by interferon-beta and type beta 1 transforming growth factor in human astrocytoma cells. Definition of cis-element. J Biol Chem. 1993 Sep 05; 268(25):18794-800.
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Immunological effects of levamisole in vitro. J Immunother (1991). 1991 Oct; 10(5):297-306.