Islet Amyloid Polypeptide

"Islet Amyloid Polypeptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A pancreatic beta-cell hormone that is co-secreted with INSULIN. It displays an anorectic effect on nutrient metabolism by inhibiting gastric acid secretion, gastric emptying and postprandial GLUCAGON secretion. Islet amyloid polypeptide can fold into AMYLOID FIBRILS that have been found as a major constituent of pancreatic AMYLOID DEPOSITS.

Descriptor ID	D058228
MeSH Number(s)	D06.472.699.587.334 D12.644.548.586.234 D12.776.049.407.500
Concept/Terms	Islet Amyloid Polypeptide Islet Amyloid Polypeptide Amyloid Polypeptide, Islet Polypeptide, Islet Amyloid Pancreatic Amylin Amylin, Pancreatic IAPP Protein Insulinoma Amyloid Polypeptide Amyloid Polypeptide, Insulinoma Polypeptide, Insulinoma Amyloid Amlintide Amylin Islet Amyloid Polypeptide Precursor Islet Amyloid Polypeptide Precursor Insulinoma Amyloid Polypeptide Precursor IAPP Precursor

Below are MeSH descriptors whose meaning is more general than "Islet Amyloid Polypeptide".

Chemicals and Drugs [D]
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
Hormones [D06.472]
Peptide Hormones [D06.472.699]
Pancreatic Hormones [D06.472.699.587]
Islet Amyloid Polypeptide [D06.472.699.587.334]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Peptide Hormones [D12.644.548]
Pancreatic Hormones [D12.644.548.586]
Islet Amyloid Polypeptide [D12.644.548.586.234]
Proteins [D12.776]
Amyloid [D12.776.049]
Amyloidogenic Proteins [D12.776.049.407]
Islet Amyloid Polypeptide [D12.776.049.407.500]

Below are MeSH descriptors whose meaning is related to "Islet Amyloid Polypeptide".

Below are MeSH descriptors whose meaning is more specific than "Islet Amyloid Polypeptide".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Islet Amyloid Polypeptide" by people in this website by year, and whether "Islet Amyloid Polypeptide" was a major or minor topic of these publications.

Bar chart showing 16 publications over 8 distinct years, with a maximum of 4 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2015	3	0	3
2016	1	0	1
2017	2	0	2
2018	4	0	4
2019	1	1	2
2020	1	0	1
2022	2	0	2

Below are the most recent publications written about "Islet Amyloid Polypeptide" by people in Profiles.

Benhamou Goldfajn N, Tang H, Ding F. Substoichiometric Inhibition of Insulin against IAPP Aggregation Is Attenuated by the Incompletely Processed N-Terminus of proIAPP. ACS Chem Neurosci. 2022 07 06; 13(13):2006-2016.

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Tang H, Sun Y, Ding F. Hydrophobic/Hydrophilic Ratio of Amphiphilic Helix Mimetics Determines the Effects on Islet Amyloid Polypeptide Aggregation. J Chem Inf Model. 2022 04 11; 62(7):1760-1770.

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Nandakumar A, Xing Y, Aranha RR, Faridi A, Kakinen A, Javed I, Koppel K, Pilkington EH, Purcell AW, Davis TP, Faridi P, Ding F, Ke PC. Human Plasma Protein Corona of Aß Amyloid and Its Impact on Islet Amyloid Polypeptide Cross-Seeding. Biomacromolecules. 2020 02 10; 21(2):988-998.

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Kakinen A, Xing Y, Hegoda Arachchi N, Javed I, Feng L, Faridi A, Douek AM, Sun Y, Kaslin J, Davis TP, Higgins MJ, Ding F, Ke PC. Single-Molecular Heteroamyloidosis of Human Islet Amyloid Polypeptide. Nano Lett. 2019 09 11; 19(9):6535-6546.

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Sun Y, Kakinen A, Xing Y, Faridi P, Nandakumar A, Purcell AW, Davis TP, Ke PC, Ding F. Amyloid Self-Assembly of hIAPP8-20 via the Accumulation of Helical Oligomers, a-Helix to ß-Sheet Transition, and Formation of ß-Barrel Intermediates. Small. 2019 05; 15(18):e1805166.

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Sun Y, Kakinen A, Xing Y, Pilkington EH, Davis TP, Ke PC, Ding F. Nucleation of ß-rich oligomers and ß-barrels in the early aggregation of human islet amyloid polypeptide. Biochim Biophys Acta Mol Basis Dis. 2019 02 01; 1865(2):434-444.

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Wang M, Sun Y, Cao X, Peng G, Javed I, Kakinen A, Davis TP, Lin S, Liu J, Ding F, Ke PC. Graphene quantum dots against human IAPP aggregation and toxicity in vivo. Nanoscale. 2018 Nov 01; 10(42):19995-20006.

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Faridi A, Sun Y, Okazaki Y, Peng G, Gao J, Kakinen A, Faridi P, Zhao M, Javed I, Purcell AW, Davis TP, Lin S, Oda R, Ding F, Ke PC. Mitigating Human IAPP Amyloidogenesis In Vivo with Chiral Silica Nanoribbons. Small. 2018 11; 14(47):e1802825.

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Sun Y, Ge X, Xing Y, Wang B, Ding F. ß-barrel Oligomers as Common Intermediates of Peptides Self-Assembling into Cross-ß Aggregates. Sci Rep. 2018 07 09; 8(1):10353.

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Xing Y, Pilkington EH, Wang M, Nowell CJ, Kakinen A, Sun Y, Wang B, Davis TP, Ding F, Ke PC. Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide. Phys Chem Chem Phys. 2017 Nov 22; 19(45):30627-30635.

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