Protein Aggregation, Pathological
"Protein Aggregation, Pathological" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as MUTATION, POST-TRANSLATIONAL MODIFICATIONS, and environmental stress, it is generally associated with ALZHEIMER DISEASE; PARKINSON DISEASE; HUNTINGTON DISEASE; and TYPE 2 DIABETES MELLITUS.
| Descriptor ID |
D066263
|
| MeSH Number(s) |
C23.550.770 G02.111.675
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Protein Aggregation, Pathological".
Below are MeSH descriptors whose meaning is more specific than "Protein Aggregation, Pathological".
This graph shows the total number of publications written about "Protein Aggregation, Pathological" by people in this website by year, and whether "Protein Aggregation, Pathological" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 3 | 3 |
| 2015 | 1 | 0 | 1 |
| 2016 | 3 | 0 | 3 |
| 2018 | 1 | 0 | 1 |
| 2019 | 1 | 1 | 2 |
| 2021 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein Aggregation, Pathological" by people in Profiles.
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Secretagogin is a Ca2+-dependent stress-responsive chaperone that may also play a role in aggregation-based proteinopathies. J Biol Chem. 2022 09; 298(9):102285.
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The long and winding road to target protein misfolding in cardiovascular diseases. Eur J Clin Invest. 2021 May; 51(5):e13504.
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Secretagogin Binding Prevents a-Synuclein Fibrillation. Biochemistry. 2019 11 19; 58(46):4585-4589.
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Single-Molecular Heteroamyloidosis of Human Islet Amyloid Polypeptide. Nano Lett. 2019 09 11; 19(9):6535-6546.
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Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy. Hum Mol Genet. 2018 08 15; 27(16):2874-2892.
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Pre-amyloid oligomers budding:a metastatic mechanism of proteotoxicity. Sci Rep. 2016 10 24; 6:35865.
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Role of tissue transglutaminase-2 (TG2)-mediated aminylation in biological processes. Amino Acids. 2017 03; 49(3):501-515.
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Stabilizing Off-pathway Oligomers by Polyphenol Nanoassemblies for IAPP Aggregation Inhibition. Sci Rep. 2016 Jan 14; 6:19463.
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Inhibition of IAPP aggregation by insulin depends on the insulin oligomeric state regulated by zinc ion concentration. Sci Rep. 2015 Feb 04; 5:8240.
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Protein post-translational modifications and misfolding: new concepts in heart failure. Proteomics Clin Appl. 2014 Aug; 8(7-8):534-42.